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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Bob on May 7, 2005, at 13:56:38
If Effexor XR is accepted as one of the worst pysch meds to taper off of, and Prozac is considered one of the easiest, where does Nardil fall in that lineup? Are MAOIs exceptionally hard to stop taking for a lot of people?
Posted by SLS on May 7, 2005, at 16:57:53
In reply to MAOI (especially Nardil) withdrawal, posted by Bob on May 7, 2005, at 13:56:38
> If Effexor XR is accepted as one of the worst pysch meds to taper off of, and Prozac is considered one of the easiest, where does Nardil fall in that lineup? Are MAOIs exceptionally hard to stop taking for a lot of people?
>I have found that MAOIs are among the easiest of antidepressant drugs to discontinue as long as you are patient enough to follow a gradual taper. If you taper too rapidly, you will experience many of the same withdrawal symptoms that people coming off of SRIs experience, including brain zaps. In addition, REM rebound can become a prominent withdrawal symptom. Dreaming becomes intense and excessive with occasional hypnagogic (at sleep onset) and hypnopompic (upon awakening) states. This includes sleep paralysis.
I spend about 2 weeks tapering from dosages of:
Parnate 80mg
Nardil 90mgPerhaps you can reduce the dosage by 1 pill every 3 days. Of course, if you have more time to work with, by all means use it.
Unfortunately, my CNS is no longer "naive" to these drugs, and I find them much easier to get off of now than the first few times I tried them.
- Scott
Posted by Bob on May 8, 2005, at 9:29:13
In reply to Re: MAOI (especially Nardil) withdrawal, posted by SLS on May 7, 2005, at 16:57:53
> > If Effexor XR is accepted as one of the worst pysch meds to taper off of, and Prozac is considered one of the easiest, where does Nardil fall in that lineup? Are MAOIs exceptionally hard to stop taking for a lot of people?
> >
>
> I have found that MAOIs are among the easiest of antidepressant drugs to discontinue as long as you are patient enough to follow a gradual taper. If you taper too rapidly, you will experience many of the same withdrawal symptoms that people coming off of SRIs experience, including brain zaps. In addition, REM rebound can become a prominent withdrawal symptom. Dreaming becomes intense and excessive with occasional hypnagogic (at sleep onset) and hypnopompic (upon awakening) states. This includes sleep paralysis.
>
> I spend about 2 weeks tapering from dosages of:
>
> Parnate 80mg
> Nardil 90mg
>
> Perhaps you can reduce the dosage by 1 pill every 3 days. Of course, if you have more time to work with, by all means use it.
>
> Unfortunately, my CNS is no longer "naive" to these drugs, and I find them much easier to get off of now than the first few times I tried them.
>
>
> - Scott
I'm not actually on an MAOI, but I have had problems getting off of just about everything I've ever taken, with Effexor and Clonazepam at the top. It is heartening, though, to hear that MAOI's may not be that bad if they are tapered slowly.Bob
Posted by ed_uk on May 8, 2005, at 11:27:38
In reply to Re: MAOI (especially Nardil) withdrawal » SLS, posted by Bob on May 8, 2005, at 9:29:13
Hi Bob,
Most people on p-babble seem to have found MAOI withdrawal relatively easy provided that they tapered. I think jerrympls had a really bad withdrawal from Nardil though, I don't know whether (or not) he tapered.
Regards,
Ed.
Posted by Chairman_MAO on May 8, 2005, at 11:38:41
In reply to Re: MAOI (especially Nardil) withdrawal, posted by SLS on May 7, 2005, at 16:57:53
I don't know why this popped into my head, but I figured you might be interested:
Harmala alkaloids, which are generally RIMAs (you probably knew that) also are imidazoline receptor agonists of varying potencies. In particluar, 6-methoxyharmalan (which, in one study, mice/rats [forget which] discriminated for ibogaine something like 85% of the time) I believe is potent enough to give significant MAO-A inhibition for around 6 hours (IIRC) at a dose of around 4mg. Given the putative involvement of the imidazoline system in many psychiatric disorders, and your own positive response to chlorgyline (you said this was the best AD you ever tried, right?), I wonder if you'd ever considered trying one of those. I know they're not pharmaceutical drugs, but I know I would try it if I couldn't get close to remission from the FDA-approved stuff.
I'm actually working with someone trying to commission a custom synthesis of 6-methoxyharmalan to use in an "Alternative"-ish antidepressant product.
This is the end of the thread.
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