Posted by Chairman_MAO on May 8, 2005, at 11:38:41
In reply to Re: MAOI (especially Nardil) withdrawal, posted by SLS on May 7, 2005, at 16:57:53
I don't know why this popped into my head, but I figured you might be interested:
Harmala alkaloids, which are generally RIMAs (you probably knew that) also are imidazoline receptor agonists of varying potencies. In particluar, 6-methoxyharmalan (which, in one study, mice/rats [forget which] discriminated for ibogaine something like 85% of the time) I believe is potent enough to give significant MAO-A inhibition for around 6 hours (IIRC) at a dose of around 4mg. Given the putative involvement of the imidazoline system in many psychiatric disorders, and your own positive response to chlorgyline (you said this was the best AD you ever tried, right?), I wonder if you'd ever considered trying one of those. I know they're not pharmaceutical drugs, but I know I would try it if I couldn't get close to remission from the FDA-approved stuff.
I'm actually working with someone trying to commission a custom synthesis of 6-methoxyharmalan to use in an "Alternative"-ish antidepressant product.
poster:Chairman_MAO
thread:494886
URL: http://www.dr-bob.org/babble/wdrawl/20050424/msgs/495178.html