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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by bulldog2 on June 1, 2008, at 18:40:52
I've know several people who used this combo and liked the synergistic effect. I'm talking selegiline 5 to 10 milligrams. At this dose there should be no effect on serotonin so no threat of serptomim sydrome.Any one ever use this combo?
Posted by undopaminergic on June 2, 2008, at 2:39:49
In reply to SSRI + Low Dose Selegiline, posted by bulldog2 on June 1, 2008, at 18:40:52
> I've know several people who used this combo and liked the synergistic effect. I'm talking selegiline 5 to 10 milligrams. At this dose there should be no effect on serotonin so no threat of serptomim sydrome.Any one ever use this combo?
>Yes, briefly with sertraline, and even more briefly with escitalopram.
Posted by iforgotmypassword on June 5, 2008, at 6:31:29
In reply to Re: SSRI + Low Dose Selegiline, posted by undopaminergic on June 2, 2008, at 2:39:49
i tried selegiline once. but i was 20, i am now 24. i didn't really notice anything.
i think i am going to start it again and keep on it indefinately as many of symptoms are pseudo parkinsonian. (f***ed up stiffness, periodic ridiculous and awful feelings in nerves, avolition, apathy, executive dysfunction, loss of natural personality and all creative interests possible, akathisia, mild to moderate dyskinesias (goes nuts in awful episodes))
i hope selegiline will protect me from further damage, but then again, i am also hoping that my symptoms are not from cell death at all.
then again, i don't know if selegiline really cancels out cell death either...
all i know is that i want to keep as many dopamergic neurons for as long as possible. i wouldn't mind never losing any again, and having more than people usually do at specific ages. it is my life force after all.
Posted by rgb on June 7, 2008, at 6:04:50
In reply to SSRI + Low Dose Selegiline, posted by bulldog2 on June 1, 2008, at 18:40:52
I'm interested in this combination too. Some relevant issues:
* Is the MAO-A inhibition reversible or irreversible? If it is irreversible, I'd be afraid that the MAO-A inhibition would slowly build up (without dose increase) to the point of serotonin syndrome.
* AFAIR, oral bioavailability is low and has considerable variance (correct me if I'm wrong). Isn't this a problem with regards to the low safety margin when using together with SSRIs?
Posted by Amigan on June 8, 2008, at 13:29:20
In reply to SSRI + Low Dose Selegiline, posted by bulldog2 on June 1, 2008, at 18:40:52
> I've know several people who used this combo and liked the synergistic effect. I'm talking selegiline 5 to 10 milligrams. At this dose there should be no effect on serotonin so no threat of serptomim sydrome.Any one ever use this combo?
I have tried with caution with no ill effects. At 10mg's.
This is the end of the thread.
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