Posted by rgb on June 7, 2008, at 6:04:50
In reply to SSRI + Low Dose Selegiline, posted by bulldog2 on June 1, 2008, at 18:40:52
I'm interested in this combination too. Some relevant issues:
* Is the MAO-A inhibition reversible or irreversible? If it is irreversible, I'd be afraid that the MAO-A inhibition would slowly build up (without dose increase) to the point of serotonin syndrome.
* AFAIR, oral bioavailability is low and has considerable variance (correct me if I'm wrong). Isn't this a problem with regards to the low safety margin when using together with SSRIs?
poster:rgb
thread:832395
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/833432.html