![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 3 to 27 of 27. Go back in thread:
Posted by tecknohed on January 22, 2008, at 10:15:07
In reply to Re: Making PEA 'active' with MAOIs » tecknohed, posted by Phoenix1 on January 22, 2008, at 9:02:17
> Hi teck
>
> What is the source of the PEA? I don't think I've ever seen a PEA supplement. The older MAOI's do inhibit catabolism of phenethylamines. I don't know what the dangers are, but look at what happens when substitued PEA's like MDMA are combined with MAOIs. Hyperpyrexic crisis I believe. Correct me if I'm wrong.
>
> Phoenix1Phoenix1, you can buy it legally here: http://www.1fast400.com/?products_id=4946
Even the advert admits that "Most PEA absorbed from the bowel is destroyed in the blood or liver by the enzyme MAO-B".Read the reviews here: http://www.1fast400.com/product_reviews.php?products_id=4946
Read this one especially: http://www.1fast400.com/product_reviews_info.php?reviews_id=12672Even though there are many phenethylamine related drugs (like MDMA, Mescaline, etc), PEA on its own has very little effect on man, even through IV injections. I doubt chocolate 'buzz' has anything to do with its PEA content. Seems you must inhibit the MAO-B to allow it to reach & pass the BBB. Of course PEA made WITHIN the brain does have an effect, supposedly that 'falling in love' feeling.
Ever read PIHKAL (Phenethylamines I Have Known And Loved) by Alexander Shulgin? Its a fantastic read - HIGHLY recommended.
http://en.wikipedia.org/wiki/PiHKAL
http://en.wikipedia.org/wiki/Alexander_Shulginteck
Posted by Phillipa on January 22, 2008, at 12:46:41
In reply to Re: Making PEA 'active' with MAOIs » Phoenix1, posted by tecknohed on January 22, 2008, at 10:15:07
Above my head for sure. Phillipa
Posted by Phoenix1 on January 22, 2008, at 13:11:56
In reply to Re: Making PEA 'active' with MAOIs » Phoenix1, posted by tecknohed on January 22, 2008, at 10:15:07
> > Hi teck
> >
> > What is the source of the PEA? I don't think I've ever seen a PEA supplement. The older MAOI's do inhibit catabolism of phenethylamines. I don't know what the dangers are, but look at what happens when substitued PEA's like MDMA are combined with MAOIs. Hyperpyrexic crisis I believe. Correct me if I'm wrong.
> >
> > Phoenix1
>
> Phoenix1, you can buy it legally here: http://www.1fast400.com/?products_id=4946
> Even the advert admits that "Most PEA absorbed from the bowel is destroyed in the blood or liver by the enzyme MAO-B".
>
> Read the reviews here: http://www.1fast400.com/product_reviews.php?products_id=4946
> Read this one especially: http://www.1fast400.com/product_reviews_info.php?reviews_id=12672
>
> Even though there are many phenethylamine related drugs (like MDMA, Mescaline, etc), PEA on its own has very little effect on man, even through IV injections. I doubt chocolate 'buzz' has anything to do with its PEA content. Seems you must inhibit the MAO-B to allow it to reach & pass the BBB. Of course PEA made WITHIN the brain does have an effect, supposedly that 'falling in love' feeling.
>
> Ever read PIHKAL (Phenethylamines I Have Known And Loved) by Alexander Shulgin? Its a fantastic read - HIGHLY recommended.
> http://en.wikipedia.org/wiki/PiHKAL
> http://en.wikipedia.org/wiki/Alexander_Shulgin
>
> teckHi teck,
Cool, I never knew you could buy PEA. Yes, I'm a big Shulgin fan, and own a copy of pihkal. I think there's some promise to substituted phenethylamines and depression. Actually, Effexor is essentially a substituted PEA I believe. Very interesting stuff. Shulgin made and tested some substituted PEA's that seemed antidepressant but lacking in psychedelic properties. I'm not sure if any of these were developed further.
I don't know how PEA would interact with an MAOI though. It's a calculated risk. I guess you could try starting with VERY small amounts and giving yourself a break between trials. (You would still technically risk serotonin syndrome though) Interesting concept though.
Phoenix1
Posted by bleauberry on January 23, 2008, at 17:58:09
In reply to Making PEA 'active' with MAOIs, posted by tecknohed on January 21, 2008, at 21:42:58
If I'm not mistaken, D-phenylalanine creates PEA and inhibits its breakdown simultaneously. Based on my own trial of this, it sure felt that way to me. Mood lift, bigtime. Energy lift, bigtime. But it also comes with the pounding heart stuff and intense insomnia worse than any amphetamine or cocaine. I have also tried L-phenylalanine and DL-phenylalanine, but D-phenylalanine is distinctly and dramatically different than either of those in my own experience.
There was someone here I think maybe a year ago that did combine PEA with selegilene. His experience was like mine. Great feeling, but side effects out of this world. Natural PEA in the body is probably genetically programmed to be destroyed as rapidly as it is for a good reason. The stuff is way out of control when there is more than is supposed to be.
Posted by tecknohed on January 23, 2008, at 21:03:12
In reply to Re: Making PEA 'active' with MAOIs, posted by bleauberry on January 23, 2008, at 17:58:09
Thanks bleauberry.
I was aware that D/DL-Phenylalanine increase brain PEA, but I think that DLPA would be far too risky, probably putting me in definite danger of hypertensive crises. And you're right, it is strong stuff!To be honest, I'm looking for a safe 'vice' I can take with my MAOI for special occasions, etc. I dont drink, am soon quitting smoking (I hope) & although I do occasionally dabble with pot its hardly appropriate in most circumstances.
Its hard to be the only one not drinking when everyone else around you is tipsy LOL
Posted by linkadge on January 23, 2008, at 22:32:07
In reply to Re: Making PEA 'active' with MAOIs » bleauberry, posted by tecknohed on January 23, 2008, at 21:03:12
PEA has a very short half life (minuates I believe), however I am under the impression that high concentrations can be neurotoxic. Not to mention makeing some people very nervous and paranoid.
Anyhow, I certainly notice that when exercising on parnate I would start to feel very strange.
I mean, I normally get a boost from exercise, but this was unreal. 20 minautes into exercise and I felt like I was entering an altranate dimention. Stuff was "larger than life", I felt like I was in a movie. Everything was looming about me, it was all very mystical and otherworldy, like perhaps this was 100 years ago, or maybe in the future. I saw that stopsign on my street one thousand times yet this time it looked different, like I had never-ever seen it before. It was scary. I wondered how I could have lived so long and yet not noticed all these things. I began to doubt everything I knew, perhaps if I was so wrong about the environment that I was wrong about everything else. I slept very little on parnate. Probably no REM sleep at all. Things were definatey not boring on Parnate, but that was the problem. I wanted boring back. I wanted it back bad. The sewer drain was very eerie. Perhaps there was a ninja turtle living down there. This presense of God became overwhelming. Every little lie I had ever told anybody in my whole entire life started to come to the forefront of my contiousness. The guilt was overwhelming. I felt I had no option but to make the wrong right. I had to confess such lies, there was no other way past them. God stared at every one of my wrongdoings, he wouldn't stop staring. It was scarry as hell.
Where am I going with this? I don't know, but MAOI's are powerfull sh*t. Perhaps those receptors would have downregulated, but I can tell you that after I discontinued parnate I experienced a euphoria like I had never known. I felt "absolved" of my sins. This dark scary place melted away.
I realized that I experienced a full blown psychotic episode while on parnate. An experience that was unparalled before or since. There is a reason that my brain is metabolizing those trace amines. Its because they are very psychoactive.
Bottom line, be carefull.Sorry for rambling.
Linkadge
Posted by tecknohed on January 24, 2008, at 0:45:33
In reply to Re: Making PEA 'active' with MAOIs, posted by linkadge on January 23, 2008, at 22:32:07
No you didn't ramble. What you said was very interesting & made lots of sense. I've had very similar experiences whilst on amphetamines combined with sleep deprivation (up to 5 days), and of course with LSD too. I think they call it 'speed psychosis'. Whilst LSD is virtually mimmicking psychosis. Must be horrible to have it caused by a med though!
I also assumed that inhibiting MAO-B would make PEA stick around for longer, maybe an hour or so. I mean it is a mono-amine right? Guess I wont know unless I try it. Not so sure that I will now though.
Thanks for your wisdome.
teck
Posted by d0pamine on January 26, 2008, at 19:26:39
In reply to Making PEA 'active' with MAOIs, posted by tecknohed on January 21, 2008, at 21:42:58
I made the mistake of trying PEA with EMSAM. I'm talking such a small amount that it was just dust on my finger tip that I touched to my tongue... BP almost instantly shot up to 180/125... The strangest part was that my face chapped out, it took several days to heal (some sort of autoimmune reaction I suppose). The feeling made adderall seem like orange juice. If you've any intention of trying such a thing, you'd certainly better make sure you're only on a selective dose of selegiline. I personally would recommend avoiding the combination altogether.
Posted by tecknohed on January 27, 2008, at 8:19:24
In reply to Re: Making PEA 'active' with MAOIs, posted by d0pamine on January 26, 2008, at 19:26:39
> I made the mistake of trying PEA with EMSAM. I'm talking such a small amount that it was just dust on my finger tip that I touched to my tongue... BP almost instantly shot up to 180/125... The strangest part was that my face chapped out, it took several days to heal (some sort of autoimmune reaction I suppose). The feeling made adderall seem like orange juice. If you've any intention of trying such a thing, you'd certainly better make sure you're only on a selective dose of selegiline. I personally would recommend avoiding the combination altogether.
Thanks d0pamine, you've helped me change my mind completely. It aint worth the risk.
Cheers!
teck
Posted by bulldog2 on January 28, 2008, at 17:03:04
In reply to Making PEA 'active' with MAOIs, posted by tecknohed on January 21, 2008, at 21:42:58
> I'm well aware that to get any significant effects from taking PEA (phenylethylamine) you need to inhibit MAO-B. Selegiline can do this.
> But what about the older MAOIs Nardil, Parnate & Marplan? Obviously it would allow you to 'feel' supplemental PEA, but would these particular MAOIs make it dangerous?
>
> I've read many anecdotal reports where people have had amazing experiences combining PEA with selegiline, with some even reporting that the high is better than crack but with little or no comedown!
>
> Your thought/experiences?
>
> teckI have had very positive results using low dose selegiline and pharmaceutical grade raw 100 % cacao powder. With the other maois I would be very cautious with this combo and try possibly a teaspoon to start.
Posted by bluemonday1968 on February 9, 2008, at 12:13:49
In reply to Re: Making PEA 'active' with MAOIs, posted by linkadge on January 23, 2008, at 22:32:07
Does pea increase concentration
and if so would running a couple of mile while on
Parnate have a positive effect on Adhd?
I gotta know
Shawn
Posted by Ron Hill on February 18, 2008, at 2:19:00
In reply to Making PEA 'active' with MAOIs, posted by tecknohed on January 21, 2008, at 21:42:58
> what about the older MAOIs Nardil, Parnate & Marplan?
> would these particular MAOIs make it dangerous?
> I've read many anecdotal reports where people have had amazing experiences combining PEA with selegiline, with some even reporting that the high is better than crack but with little or no comedown!> Your thought/experiences?
> teck
--------------------------Teck,
This post got kinda long on me. Sorry.
Please refresh my memory, Teck; are you currently taking an MAOI? If so, which one and what dosage?
A few months ago, I conducted a brief trial in which I added a small dose of PEA to my meds. At the time, my meds included 90 mg/day of Nardil.
Here is a list of all the meds and dosages I was taking at the time:
600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day NardilMy purpose for conducting the trial was to determine if the add-on PEA with Nardil would tx my bipolar depressive phase. It did not take long for me to get an answer. PEA worked great as an antidepressant; in fact it was incredible. Within minutes after taking it my depression was completely gone.
Generally speaking, research shows that depressed pts tend to have low CSF levels and low plasma levels of endogenous PEA. Further, a manic pt typically has elevated levels of PEA. Neither extreme is beneficial. Too low and the pt is at risk of depression; too high, and the pt may become agitated and overly aggressive. I bring this information up solely to lay the groundwork needed to explain the rationale behind the PEA dosing schedule that I used during my trial.
I am a bipolar II ultra-rapid cycler. I cycle once every 15 days, and my cycling period is very consistent. I can set my watch by it. I set up the trial, so as to administer PEA during my depressive phases, but not during my normal and hypomanic mood phases.
My rationale for this dosing schedule was that I needed to take exogenous PEA during my depressive phases in order to offset the deficit of endogenous PEA. On the other hand, when I cycled out of depression and into a normal mood phase or hypomanic mood phase, exogenous PEA would not be beneficial. In fact, it could induce a dysphoric mood state. Therefore, I discontinued use of exogenous PEA during my normal and hypomanic mood phases.
However, as it turned out, my PEA dosing schedule failed miserably. When I would stop taking PEA during my normal or hypomanic mood states, the rebound depression was ABSOLUTELY horrendous. The conclusion I came to was that, if I were to try PEA as an add-on to Nardil again sometime in the future, I would need to take PEA all the time, regardless of my mood state.
^ Too Much Information. ^
Ever since I aborted my original PEA trial, a part of me has really wanted to conduct a new redesigned trial of PEA added-on to Nardil. The way PEA instantly took away my depression and left me feeling calm and peaceful was remarkable.
However, my gut feeling is that PEA will work great for a while, and then it will make me VERY IRRITABLE GRRRRRRRR. And, then Id have to go through the horrendous PEA withdrawal.Teck, as you know, by far the most common MAOI to use with PEA is selegiline (Deprenyl). Typically, the selegiline dosage used is no more than 10 mg/day so that it is a selective MAOI-B. In the study linked below, Sabelli et al used 10 mg of selegiline and PEA dosages of 10 60 mg/day depending on the amount needed by any given pt.
Obviously, the selective MAOI-B eliminates the risk of a hypertensive crisis. Therefore, high PEA dosages (60 mg/day) can be safely used. However, this is not the case for Nardil. In the documents linked below, passing reference is made to the use of Nardil with PEA, but no dosage range guidance is provided.
During my trial of PEA with Nardil, I used a very cautious trial-and-error procedure to find a PEA dosage that felt right. I kept my blood pressure machine and my nifedipine close at hand. I monitored my blood pressure frequently in the beginning of the trial.
The PEA that I purchased is a bottle containing 120 capsules with each capsule containing 250 mg of PEA in a granular form. Clearly, if I would have taken a 250 mg capsule of PEA with 90 mg/day of Nardil on-board, well you can fill in the blanks.
Instead, I opened a capsule and emptied the contents onto a plate. The dosage that ended up working well for me was measured and administered as follows: I wetted the very tip of my pinky finger and touched my wetted finger tip lightly onto the granular PEA on the plate. I would then lick the PEA off of my pinky finger tip. My best rough estimate is that I was likely taking about 10 mg/day of PEA, but I really dont have an accurate value.^ Okay, enough rambling.^
The full texts of the following two documents are worth reading by any and all interested in PEA administered with an MAOI. However, let me start out by providing links to the two corresponding abstracts. As you will see below, there are a few steps required to pull up the full documents, and some people reading this post might prefer to just read the abstracts:
Sustained antidepressant effect of PEA replacement
http://neuro.psychiatryonline.org/cgi/content/abstract/8/2/168Phenylethylamine modulation of affect: therapeutic and diagnostic implications
http://neuro.psychiatryonline.org/cgi/content/abstract/7/1/6Okay, now lets pull up the full text pdf documents. Its not straight forward because the Journal of Neuropsychiatry and Clinical Neurosciences does not offer free access to their full text versions. Therefore, I hunted around and found a back door that allows us free access to the full text versions of the two articles of interest.
Here are the directions for accessing the two full text documents via the back door. Its easy:
1. Click here: http://bjsm.bmj.com/cgi/content/full/35/5/342
2. Go to the bottom of the page that you just pulled up, and click on Register for Access. Registration is free on the BJSM site.
3. Fill out the registration information.
SIDE NOTE: After registering, you might be automatically and immediately routed to the full text version of the article titled "Phenylethylamine, a possible link to the antidepressant effects of exercise?". If so, skip steps 4 and 5.
4. Click on the link in Step 1 above.5. Fill in your user name and password that you just got when you registered. The full text of the article, "Phenylethylamine, a possible link to the antidepressant effects of exercise?", will come up on your screen.
6. Scroll down until you get to the References section at the bottom of the full text document entitled, "Phenylethylamine, a possible link to the antidepressant effects of exercise?". Now we have arrived at the back door. The two articles we want are Reference 2 and Reference 3.
7. Click on the Free Full Text link for Reference 2; { Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effects of PEA replacement. J Neuropsychiatry 1996;8:16871}8. Access to the abstract of the article we want will come up. In the menu box on the right hand side of the page, (directly adjacent to the abstract text), click the first entry; Full Text (PDF).
9. Click [Begin manual download].
10. Read the full text pdf of Sustained antidepressant effects of PEA replacement.
11. Return to the References listed at the bottom of the document entitled, "Phenylethylamine, a possible link to the antidepressant effects of exercise?", and click on the Free Full Text link for Reference 3; { Sabelli H, Javaid J. Phenylethlyamine modulation of affect: therapeutic and diagnostic implications. J Neuropsychiatry Clin Neurosci 1995;7:614.}
12. Read the full text pdf of Phenylethlyamine modulation of affect: therapeutic and diagnostic implications.
13. If you have time, you may find it worthwhile to also read "Phenylethylamine, a possible link to the antidepressant effects of exercise?"
Here is a short Letter to the Editor on the PEA topic. The document of interest starts in the center column. Pay special attention to the fact that the author mentions the use of PEA with Nardil. Just click the link provided:http://neuro.psychiatryonline.org/cgi/reprint/6/2/203
Remember Teck
Rule #1: Nobody gets hurt!
Rule #2: Don't forget Rule #1!!
I care about you, Bud. Be smart, do your p-homework before you monkey with PEA, and don't do anything stupid.
-- Ron
Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)
300 mg/day Trileptal (My antimanic med left idling in the background. If I get hypomanic, I jump it up to 600 or 900 until my hypomania subsides.)
200 mg/day Lamictal
250 mg/day Keppra
75 mg/day Nardil
50 mg/day Topamax
7.5 mg/day Deplin (but I skip days periodically)
Posted by tecknohed on February 18, 2008, at 5:19:57
In reply to Re: Making PEA 'active' with MAOIs » tecknohed, posted by Ron Hill on February 18, 2008, at 2:19:00
Hey Ron, thanks sooo much for this info!
No your post was not too long. Its exactly the kind of response I was looking for.
My current Regime is:Marplan 50mg
Klonopin 3mg
Wellbutrin 300mg
+ various nootropicsI'm doing well. I'm not bipolar (as far as I know) but I DO have my 'off' days (about 1-2 days a week). And these days are pretty bad. Dont know why I have them. I had them on Nardil too. Wonder if it would be worth trying a small dose of PEA on these 'off' days? Then agan, wonder if the Wellbutrin would make it too much, too high BP? Guess its upto me to decide!
Haven't read abstracts yet- in a rush. I'll get back to you once I have though. Thanks again!
teck
Posted by tecknohed on February 18, 2008, at 5:36:53
In reply to Re: Making PEA 'active' with MAOIs » tecknohed, posted by Ron Hill on February 18, 2008, at 2:19:00
Forgot to add, I also take 25mg 5-HTP every other day, which I think is significant enough to mention. BOY it helps :)
teck
Posted by bluemonday 1968 on February 19, 2008, at 13:31:06
In reply to Re: Making PEA 'active' with MAOIs » Ron Hill, posted by tecknohed on February 18, 2008, at 5:36:53
Poking around this website http://www.cognitiveliberty.org/shulgin/blg/index.html Alexander Shugin ( The guy who created
ecstasy once tried again and again to try
Iv pea and concluded that it does not cross
the blood brain barrier.The report is also
in the "good drug guide".
Sorry about all the
typos to much of
Shugin' creations
in high school
Shawn
Posted by bluemonday 1968 on February 19, 2008, at 13:56:01
In reply to Re: Making PEA 'active' with MAOIs, posted by bluemonday 1968 on February 19, 2008, at 13:31:06
Okay here are a bunch of second opinions
I guess nothing is absolute when dealing
with the brain.http://www.chocolate.org/pea.htm
I guess I gotta buy some
chocolate right now.
Hope I did not
confuse anybody
Too old to "Rave till dawn"
Shawn
Posted by Dopamine123 on February 21, 2008, at 12:10:44
In reply to Re: Making PEA 'active' with MAOIs » tecknohed, posted by Ron Hill on February 18, 2008, at 2:19:00
"Obviously, the selective MAOI-B eliminates the risk of a hypertensive crisis."
I read in another forum that someone combined selegine (MAOI-B selective dose) with PEA and they had a hypertensive crisis. So be careful about doing it.
Here's the other forum talking about it.
http://www.abolitionist-society.com/forum/viewtopic.php?t=379&start=15
"I'm on the 9mg Emsam patch and I took 100mg of PEA from custom nutrition and experienced hypertensive crisis. My blood pressure usually runs not higher than about 110/65 or so. Twenty minutes after taking the PEA my blood pressure went up to 205/130+.
I could have died."
I don't want to be alarmist, but there is a small chance it could be dangerous.
Visit my blog about neuroscience/neurotechnology.
http://brainstimulant.blogspot.com/
Posted by zeugma on February 22, 2008, at 16:50:10
In reply to BE CAREFUL!, posted by Dopamine123 on February 21, 2008, at 12:10:44
According to this study (from some well regarded researchers at Harvard Medical School) Provigil specifically works by potentiating PEA at the dopamine transporter (this is about the thousandth mechanism I have seen posited for Provigil, but these are Harvard scientists, so maybe it will become the received wisdom on this drug until it goes off patent) :
http://jpet.aspetjournals.org/cgi/content/full/319/2/561
Posted by Lamdage on August 11, 2011, at 22:25:15
In reply to Re: Making PEA 'active' with MAOIs, posted by linkadge on January 23, 2008, at 22:32:07
> I mean, I normally get a boost from exercise, but this was unreal. 20 minautes into exercise and I felt like I was entering an altranate dimention. Stuff was "larger than life", I felt like I was in a movie. Everything was looming about me, it was all very mystical and otherworldy, like perhaps this was 100 years ago, or maybe in the future. I saw that stopsign on my street one thousand times yet this time it looked different, like I had never-ever seen it before. It was scary. I wondered how I could have lived so long and yet not noticed all these things. I began to doubt everything I knew, perhaps if I was so wrong about the environment that I was wrong about everything else.
I believe i know exactly what youre talking about. I found it to be fascinating and id like to have this feeling in miniature back for the remainder of my life. Aaah how i want this back. Yes everything looked different so i kept asking people what part of town were in in the trolley. Funny thing, they had no idea either. Lol i decided to leave it up to the universe, just cautiously approached the door. It locked. Next stop i felt i felt i should try it now, went out and it was perfect. It need to add it was nighttime.
Everything felt like lifes a game and the world is a huge playground. It was AWESOME. I agree though on the sometimes eerie feeling but most of the time i just loved it. PEA did this to you? Im gonna get it :D
Posted by Chairman_MAO on October 6, 2011, at 13:56:59
In reply to Re: Making PEA 'active' with MAOIs, posted by Lamdage on August 11, 2011, at 22:25:15
PEA on MAOIs can become incredibly dysphoric. Be careful.
You're better off using amphetamine.
Posted by EEERRRIIICCC on May 9, 2012, at 13:57:14
In reply to Making PEA 'active' with MAOIs, posted by tecknohed on January 21, 2008, at 21:42:58
It was incredible at first when added to Parnate, but continued daily use high dose use was a complete failure. It produced psychotic breaks and a manic disregard for my life and others, also I became terrified to go outside (I could but I didn't like it at all and became incredibly anxious).
Be very careful.
Posted by EEERRRIIICCC on May 9, 2012, at 13:59:11
In reply to Re: Making PEA 'active' with MAOIs » tecknohed, posted by EEERRRIIICCC on May 9, 2012, at 13:57:14
Occasional use may be great however as long as "occasional" along with the dose are arrived at carefully.
Posted by test_subject_99 on November 17, 2012, at 16:25:21
In reply to Re: Making PEA 'active' with MAOIs, posted by EEERRRIIICCC on May 9, 2012, at 13:59:11
IMPORTANT NOTE: THIS POST IS MY PERSONAL EXPERIENCE WITH PEA, A NATURALLY OCCURING MONOAMINE ALKALOID, FOUND (AND CREATED) NATURALLY IN THE BODY/BRAIN, AND IS ALSO in SOME FOODS (chocolate is one). TAKEN IT IS NOT MEANT AS A WAY TO GET 'HIGH'!! WHAT YOU ARE READING IS MY EXPERIENCE, THAT IS ALL. I WILL NOT LIE. IF ANYBODY CONSIDERS MY POSTS OR THIS THREAD TO BE AN ENCOURAGEMENT TO GET 'HIGH' YOU ARE WRONG. IF YOU DONT LIKE WHAT YOU READ HERE, OR FIND IT DISTASTEFUL THEN PLEASE, STOP READING IT.
Hi all. Just to clarify, my posting name used to be 'tecknohed', and you'll see that in the previous posts in this thread. In fact, as you can see I started the thread.
There is some very good info on the WEB regarding this subject. But for a quick, easy to understand explination of PEA + MAOIs, please check the following page:
http://en.wikipedia.org/wiki/Phenethylamine
OK. So do 'full' MAOIs (MAOIs which irreversibly inhibit MAO A & B) work well at activating PEA? Well I've ansered my own question! Firstly, a glance at my current med regime:
Isocarboxazid (full MAOI) 90mg
Clonazepam 4mg
Amitriptyline 100mg
Quetiapine 50mg
Bupropion 300mgUnfortunitely, this combo hasn't been much help for my social phobia or depression. I'm hoping the amitriptyline will kick in soon, its been 6 weeks, although I started very low and only reached the target dose of 100mg 2 weeks ago.
Anyway, so I ordered some PEA (phenylethylamine) which arived today. 500mg capsules. I took one 500mg capsule an hour ago. OMG! I feel extremely elated, stimulated, euphoric!
HOWEVER, I definitely took too much. As soon as it took effect, my heart started beating very hard, a slight headache too. Wish I had a BP reader with me. Its starting to wear off now anyway, though not completely.
When I 1st felt the effects, which built very quickly, I got worried and took 100mg quetiapine, 3mg clonazepam & some paracetamol which probably helped 'put the brakes on'. Lesson learned! Right now I'm on a nice comfortable plateau. Usually, a whole 100mg quetiapine would have sent me to noddy land, but I still feel very stimulated.
So there you go. Full MAOIs do indeed help make PEA active. Hardly surprising really! But I'm going to drop the dosage to 100mg (by emptying the capsule and dividing its contents) and climb up slowly if need be .I'm thinking I might just use it only for recreation use, or for deadlines and occasional fatigue when the depression gets bad. And despite PEA being a naturaly occuring substance, The MAOI is not and I'm wondering if I will experience a 'crash' at some point. After all, what goes up must come down! MUST buy a BP monitor/reader too.I will keep you all up to date.
TS99
(if I seemed to have 'ranted' on too much, take it as a sign that it works! I allways think/talk too much when I've taken psycho stims in the past. And despite being natural its a stimulant nonetheless :)
Posted by test_subject_99 on November 17, 2012, at 16:34:29
In reply to Re: Making PEA 'active' with MAOIs » tecknohed, posted by Phoenix1 on January 22, 2008, at 9:02:17
> Hi teck
>
> What is the source of the PEA? I don't think I've ever seen a PEA supplement. The older MAOI's do inhibit catabolism of phenethylamines. I don't know what the dangers are, but look at what happens when substitued PEA's like MDMA are combined with MAOIs. Hyperpyrexic crisis I believe. Correct me if I'm wrong.
>
> Phoenix1MAOIs with ecstacy (MDMA)?? For reference only I've taken MDMA on an MAOI (isocarboxazid) withought problems. But its NOT clever and NOT something I'd encourage.
Posted by test_subject_99 on December 12, 2012, at 18:06:34
In reply to Re: Making PEA 'active' with MAOIs, posted by test_subject_99 on November 17, 2012, at 16:25:21
Sorry for such a late responce.
Just wanna be brief. IT WORKS! If fact its similar to effects of most psycho stims - thought process incraeses 10fold and its an awesome mood booster - great to take if its been a while since you've felt 'up'. You do feel icky though on the comedown. 250mg seems to feel same as 500mg, just not as long lasting. Big difference here though is that it gives no boost on energy levels at all. If fact taking a walk on this stuff leaves me outa breath!
This is the end of the thread.
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