Posted by Phoenix1 on January 22, 2008, at 13:11:56
In reply to Re: Making PEA 'active' with MAOIs » Phoenix1, posted by tecknohed on January 22, 2008, at 10:15:07
> > Hi teck
> >
> > What is the source of the PEA? I don't think I've ever seen a PEA supplement. The older MAOI's do inhibit catabolism of phenethylamines. I don't know what the dangers are, but look at what happens when substitued PEA's like MDMA are combined with MAOIs. Hyperpyrexic crisis I believe. Correct me if I'm wrong.
> >
> > Phoenix1
>
> Phoenix1, you can buy it legally here: http://www.1fast400.com/?products_id=4946
> Even the advert admits that "Most PEA absorbed from the bowel is destroyed in the blood or liver by the enzyme MAO-B".
>
> Read the reviews here: http://www.1fast400.com/product_reviews.php?products_id=4946
> Read this one especially: http://www.1fast400.com/product_reviews_info.php?reviews_id=12672
>
> Even though there are many phenethylamine related drugs (like MDMA, Mescaline, etc), PEA on its own has very little effect on man, even through IV injections. I doubt chocolate 'buzz' has anything to do with its PEA content. Seems you must inhibit the MAO-B to allow it to reach & pass the BBB. Of course PEA made WITHIN the brain does have an effect, supposedly that 'falling in love' feeling.
>
> Ever read PIHKAL (Phenethylamines I Have Known And Loved) by Alexander Shulgin? Its a fantastic read - HIGHLY recommended.
> http://en.wikipedia.org/wiki/PiHKAL
> http://en.wikipedia.org/wiki/Alexander_Shulgin
>
> teckHi teck,
Cool, I never knew you could buy PEA. Yes, I'm a big Shulgin fan, and own a copy of pihkal. I think there's some promise to substituted phenethylamines and depression. Actually, Effexor is essentially a substituted PEA I believe. Very interesting stuff. Shulgin made and tested some substituted PEA's that seemed antidepressant but lacking in psychedelic properties. I'm not sure if any of these were developed further.
I don't know how PEA would interact with an MAOI though. It's a calculated risk. I guess you could try starting with VERY small amounts and giving yourself a break between trials. (You would still technically risk serotonin syndrome though) Interesting concept though.
Phoenix1
poster:Phoenix1
thread:808257
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/808332.html