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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by clipper40 on January 29, 2008, at 1:32:00
What drugs have people here combined with Remeron?
Rxlist.com states that it's not entirely possible to know what Remeron can be combined with because of the P450 thing:
"Drugs that are Metabolized by and/or Inhibit Cytochrome P450 Enzymes
"Many drugs are metabolized by and/or inhibit various cytochrome P450 enzymes, e.g., 2D6, 1A2, 3A4, etc. In vitro studies have shown that mirtazapine is a substrate for several of these enzymes, including 2D6, 1A2, and 3A4. While in vitro studies have shown that mirtazapine is not a potent inhibitor of any of these enzymes, an indication that mirtazapine is not likely to have a clinically significant inhibitory effect on the metabolism of other drugs that are substrates for these cytochrome P450 enzymes, the concomitant use of REMERON® with most other drugs metabolized by these enzymes has not been formally studied. Consequently, it is not possible to make any definitive statements about the risks of coadministration of REMERON® with such drugs."
_______________________________________________I can't imagine that adding a little bit of Prozac or Zoloft for a few days just to help someone with Effexor withdrawal (who is also taking Remeron) could be much of a problem, can you?
Posted by tensor on January 29, 2008, at 1:32:01
In reply to What meds can/can't be combined w/ Remeron?, posted by clipper40 on January 28, 2008, at 22:02:25
I have combined Remeron with *plenty* of different drugs, incl. SSRI, TCA and atypical AD's. No notable interations. Please note that if another drug is metabolized by the same enzymes it doesn't mean that they are incompatible.
/Mattias
Posted by clipper40 on January 29, 2008, at 3:13:30
In reply to Re: What meds can/can't be combined w/ Remeron? » clipper40, posted by tensor on January 29, 2008, at 1:32:01
Thanks. I know that they're not incompatible because they're metabolized by the same enzymes but I am concerned with how much they might increase the concentration(s) of one or both of the drugs involved. I'm especially concerned about Prozac in this respect. Did you combine Remeron with Prozac by any chance?
Posted by Phillipa on January 29, 2008, at 12:15:07
In reply to Re: What meds can/can't be combined w/ Remeron? » tensor, posted by clipper40 on January 29, 2008, at 3:13:30
I also took remeron l5mg with another SSRI I think it was zoloft . No experience with it with prozac. Remeron did nothing for me. So after about six weeks pdoc said to stop it. Phillipa
Posted by clipper40 on January 29, 2008, at 19:14:13
In reply to Re: What meds can/can't be combined w/ Remeron? » clipper40, posted by Phillipa on January 29, 2008, at 12:15:07
Thanks. I think I would feel safe recommending it now along with an SSRI.
Posted by Molybdenum on January 30, 2008, at 16:38:22
In reply to What meds can/can't be combined w/ Remeron?, posted by clipper40 on January 29, 2008, at 1:32:00
Effexor is a common mixer with Remeron. I think it's sometimes called "California Rocket Fuel" - google that ;)
From p290 "Stephen M. Stahl - Essential Psychopharmacology.pdf" :
"Heroic combo 1, or "California rocket fuel": High-dose venlafaxine plus mirtazapine.
This is a combination of antidepressants that has a great degree of theoretical synergy: reuptake
blockade plus alpha 2 blockade; serotonin reuptake plus 5HT2A antagonism; 5HT actions plus NE
actions. Specifically, 5HT is triple-boosted, with reuptake blockade, alpha 2 antagonism, and 5HT2A
antagonism; NE is double-boosted, with reuptake blockade plus alpha 2 antagonism; and there may
even be a bit of single boost to DA from reuptake blockade."BTW, this PDF book is widely available from P2P networks. The book talks about a lot of other combos too.
Posted by clipper40 on January 30, 2008, at 22:38:43
In reply to Re: What meds can/can't be combined w/ Remeron?, posted by Molybdenum on January 30, 2008, at 16:38:22
I've known about "California rocket fuel". Didn't know that Stahl's book was available online. That's fantastic information. Thanks so much!!!
Posted by elanor roosevelt on February 1, 2008, at 0:15:03
In reply to Re: What meds can/can't be combined w/ Remeron? » Molybdenum, posted by clipper40 on January 30, 2008, at 22:38:43
how do y'all sleep on remeron
my dreams were structured quests at which i never succeeded
strange
different meds, different dreams
Posted by Molybdenum on February 1, 2008, at 3:58:23
In reply to Dreaming w/ Remeron?, posted by elanor roosevelt on February 1, 2008, at 0:15:03
> how do y'all sleep on remeron
>
> my dreams were structured quests at which i never succeeded
>
> strange
>
> different meds, different dreamsCitalopram used to give me "vivid dreams" nearly every night. Really quite entertaining ones. Bizarre landscapes, societies & often with flying involved. Lots of "moving" through walls in buildings. I've kept some citalopram because of this even though it pooped out on me years ago.
I've occasionally popped a couple going to bed but never got the same results. Maybe it's an accumulated thing.
I've never had the venlafaxine on it's own. I have always had it along with mirtazapine. My dreams are often vivid but not anything like they were on citalopram. I sometimes have really bad nightmares now. They all seem ridiculous to talk about the next day to anyone but at the time, I'll wake up & feel AWFUL...and SAD.
I think mirtazapine in general helps me get to sleep & stay asleep. But I have read that the sedating effects are more pronounced at the lower doses (15mg?).
Maybe twice a year I still have such a vivid & "awe inspiring" dream that I wake up really pissed to be back in my real life.
It's all so depressing.
Now I'm on a role: the most beautiful experiences of my life were taking LSD. I remember the first time. It was in a park on a bright sunny day with a good friend. I watched the clouds merge into each other. We rolled around like nuts on the grass for hours. It was the best day of my life. That was over 20 years ago....
When it was wearing off later that night we walked up to McDonalds and ordered some cheeseburgers. I remember opening it up on the table & sliding the pickle around in the sauce with my finger. It was a fantastic sensation. So we both started doing it & were giggling with joy.....!
The manager came over & said "GET OUT..!"
hahahahahahaa..........I wish I had LSD again & not all these crappy anti-depressants, downers & uppers. :( Now I am sad. :(
sweet dreams....
Posted by elanor roosevelt on February 1, 2008, at 13:54:38
In reply to Re: Dreaming w/ Remeron?, posted by Molybdenum on February 1, 2008, at 3:58:23
> Citalopram used to give me "vivid dreams" nearly every night. Really quite entertaining ones. Bizarre landscapes, societies & often with flying involved. Lots of "moving" through walls in buildings. vivid & "awe inspiring" dream that I wake up really pissed to be back in my real life.
This makes me want to take citalopramit also reminded me about mugwort
sleeping with a little pillow of mugwort can trigger very elaborate dreams
Think I'll get some
either luvox or serzone gave me ugly dreams (me drowning baby animals and such)
trivastal triggered erotic dreams at first
there are societies that treat the dreaming life as of equal importance to the waking life
Posted by Molybdenum on February 1, 2008, at 16:36:48
In reply to Re: Dreaming w/ Remeron?, posted by elanor roosevelt on February 1, 2008, at 13:54:38
>
> > Citalopram used to give me "vivid dreams" nearly every night. Really quite entertaining ones. Bizarre landscapes, societies & often with flying involved. Lots of "moving" through walls in buildings. vivid & "awe inspiring" dream that I wake up really pissed to be back in my real life.
> This makes me want to take citalopram
>
> it also reminded me about mugwort
>
> sleeping with a little pillow of mugwort can trigger very elaborate dreams
>
> Think I'll get some
>
> either luvox or serzone gave me ugly dreams (me drowning baby animals and such)
>
> trivastal triggered erotic dreams at first
>
> there are societies that treat the dreaming life as of equal importance to the waking life
>
>I remember having the vivid citalopram dreams even on low doses of 20-40mg. So no need to go too high to start with - assuming it will do the same for you.
I think it's odd the way doctors (at least the ones I've seen) seem to ignore dreams. We spend about 1/3 of our lives asleep. Seems stupid to just shrug it off in the morning as if it were some bad TV.
Even my Psyc-Dr disregards them. He says "Ahh but it's not real". Seemed damned real to me at the time. And it sure beats this real.
Actually (and I know I'm way off topic here) but I've been reading the Dune series of sci-fi books. They mine a drug called "spice" that helps them to see possible futures, prolong life and of course - to "navigate across the universe though fold-space"... :)
Good Luck & Have fun ;)
Posted by elanor roosevelt on February 2, 2008, at 18:30:19
In reply to Re: Dreaming w/ Remeron?, posted by Molybdenum on February 1, 2008, at 3:58:23
> Citalopram used to give me "vivid dreams" nearly every night. Really quite entertaining ones. Bizarre landscapes, societies & often with flying involved. Lots of "moving" through walls in buildings. vivid & "awe inspiring" dream that I wake up really pissed to be back in my real life.
This makes me want to take citalopramit also reminded me about mugwort
sleeping with a little pillow of mugwort can trigger very elaborate dreams
Think I'll get some
either luvox or serzone gave me ugly dreams (me drowning baby animals and such)
trivastal triggered erotic dreams at first
there are societies that treat the dreaming life as of equal importance to the waking life
Posted by Sigismund on February 3, 2008, at 1:24:45
In reply to Re: Dreaming w/ Remeron?, posted by elanor roosevelt on February 1, 2008, at 13:54:38
The herbalist persuaded me to have some in my latest sleep mix, in with the
zizyphus
skullcap
lemon balmShe said it was like a big hug, which has not, so far, been my experience. Still, the mixture works.
This is the end of the thread.
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