![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by D minor on September 30, 2004, at 21:22:09
Vioxx has been recalled by the manufacturer. Any who are currently taking it should discontinue usage and talk to their doctors.
dm
Posted by saw on October 2, 2004, at 1:43:54
In reply to Vioxx Recalled, posted by D minor on September 30, 2004, at 21:25:22
I've used this before, but can't remember why. I think it was for bad period pain. Is it a pain killer?
Sabrina
Posted by Sad Panda on October 2, 2004, at 1:43:55
In reply to Re: Vioxx Recalled, posted by saw on October 1, 2004, at 5:16:22
> I've used this before, but can't remember why. I think it was for bad period pain. Is it a pain killer?
>
> Sabrina
>
>It's a COX-2 type NSAID ideally suited to pain releif caused by inflamation particularly for arthritis.
I take Celebrex myself, previously i took Voltaren. Vioxx being taken off the market is pretty big news actually.
Cheers,
Paul.
Posted by gromit on October 4, 2004, at 2:55:17
In reply to Re: Vioxx Recalled, posted by Sad Panda on October 1, 2004, at 5:33:23
> It's a COX-2 type NSAID ideally suited to pain releif caused by inflamation particularly for arthritis.
>
> I take Celebrex myself, previously i took Voltaren. Vioxx being taken off the market is pretty big news actually.Arghhh, this quote makes me nervous.
"Today's announcement by Merck is the latest evidence that this family of drugs, the Cox-2 inhibitors, once referred to as "super aspirins,"
are turning out to be more like super disasters."I'm taking Bextra and was taking Celebrex, I'll have to ask my GP when I see her next. I'd rather not be a data point.
Posted by tealady on November 23, 2004, at 23:13:16
In reply to Vioxx withdrawal, posted by tealady on October 1, 2004, at 5:07:30
> Not sure if anyone is interested.
> I've only tried NSAID's once for pain, and didn't like them.
>
>
> Merck & Co., Inc. announced a voluntary withdrawal of Vioxx (rofecoxib) from the U.S. and worldwide market due to safety concerns of an increased risk of cardiovascular events (including heart attack and stroke) in patients on
> Vioxx. Vioxx is a prescription COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) that was approved by FDA in May 1999 for the relief of the signs and symptoms of osteoarthritis, for the management of acute pain in adults, and for the treatment of menstrual symptoms, and was later approved for the relief of the signs and symptoms of rheumatoid arthritis in adults and children.
>
> Read the 2004 MedWatch safety summary, including links to the Public Health
> Advisory, press release, and Q&As, at:
>
> http://www.fda.gov/medwatch/SAFETY/2004/safety04.htm#vioxx
>
> -------------------
>
> Statement by Sidney M. Wolfe, MD, Director of Public Citizen's Health
> Research Group, Concerning Withdrawal of Vioxx From the Market
>
> Today's announcement by Merck is the latest evidence that this family of drugs, the Cox-2 inhibitors, once referred to as "super aspirins,"
> are turning out to be more like super disasters.
>
> In an article published three and a half years ago in our monthly newsletter, Worst Pills, Best Pills News (now online at
> http://www.WorstPills.org/vioxxqd/ ), we warned readers that both Vioxx and Celebrex were DO NOT USE drugs - our designation for drugs
> that are not safe and effective enough to use. Although Merck's withdrawal of Vioxx "solves" the serious safety problems with this drug, the most-prescribed alternatives, Celebrex and Bextra, also have some concerns about their cardiac toxicity.
>http://www.heartcenteronline.com/myheartdr/home/research-detail.cfm?reutersid=4884&nl=3
Study suggests how COX drugs cause heart disease
advertisement
Nov 19 (Reuters) - Painkillers suspected of causing fatal heart disease may act by starting the process of hardening the arteries, researchers proposed on Thursday.The drugs, known as COX-2 inhibitors, include Merck and Co.'s Vioxx, which earned the company $2.55 billion a year but was pulled off the market on Sept. 30 after a study showed it doubled the risk of heart attack and stroke.
Tests on mice suggest COX-2 inhibitors might be especially dangerous to younger women, who are normally protected by biology from heart disease.
The research, published in Friday's issue of the journal Science, also supports the theory that there could be a "class effect," meaning that all brands of COX-2 inhibitors could raise the risk of heart disease.
Jan
Posted by tealady on November 23, 2004, at 23:13:16
In reply to Study suggests how COX drugs cause heart disease h, posted by tealady on November 23, 2004, at 19:35:19
Common drug may hinder recovery from heart attack
advertisement
Nov 11 (HeartCenterOnline) - Heart attack patients who are taking some newer generation COX-2 inhibitors may face a longer, more difficult road to recovery.
COX-2 inhibitors, including the recently recalled Vioxx, are anti-inflammatories commonly prescribed to treat arthritis.However, researchers at the University of Alberta have found that COX-2 inhibitors compromise a basic cellular process that balances the pH within cells. It is critical among heart attack patients that affected cells return to the correct pH as soon as possible for complete recovery, so any medication that disrupts this process has the potential for hindering recovery.
At issue is COX-2's ability to inhibit the action of enzymes called bicarbonate transporters. These enzymes are responsible for moving bicarbonate across the cell membrane in response to very slight shifts in pH. Bicarbonate is the body's main pH buffer, and the mechanism to control it is very sensitive. Bicarbonate is also the main cellular waste product from energy production.
The effect of COX-2 on bicarbonate transporter enzymes was discovered by a team at the University of Alberta. Their work will appear in the Nov. 23 issue of the journal Molecular Membrane Biology.
---------------------------------------
gee I didn't take many of these and none in the past 9 months..but it might hav explained some things if I had
Jan
This is the end of the thread.
Psycho-Babble Health | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.