Posted by tealady on November 23, 2004, at 20:20:24 [reposted on November 23, 2004, at 23:13:16 | original URL]
In reply to Study suggests how COX drugs cause heart disease h, posted by tealady on November 23, 2004, at 19:35:19
Common drug may hinder recovery from heart attack
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Nov 11 (HeartCenterOnline) - Heart attack patients who are taking some newer generation COX-2 inhibitors may face a longer, more difficult road to recovery.
COX-2 inhibitors, including the recently recalled Vioxx, are anti-inflammatories commonly prescribed to treat arthritis.However, researchers at the University of Alberta have found that COX-2 inhibitors compromise a basic cellular process that balances the pH within cells. It is critical among heart attack patients that affected cells return to the correct pH as soon as possible for complete recovery, so any medication that disrupts this process has the potential for hindering recovery.
At issue is COX-2's ability to inhibit the action of enzymes called bicarbonate transporters. These enzymes are responsible for moving bicarbonate across the cell membrane in response to very slight shifts in pH. Bicarbonate is the body's main pH buffer, and the mechanism to control it is very sensitive. Bicarbonate is also the main cellular waste product from energy production.
The effect of COX-2 on bicarbonate transporter enzymes was discovered by a team at the University of Alberta. Their work will appear in the Nov. 23 issue of the journal Molecular Membrane Biology.
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gee I didn't take many of these and none in the past 9 months..but it might hav explained some things if I had
Jan
poster:tealady
thread:397624
URL: http://www.dr-bob.org/babble/health/20041005/msgs/419539.html