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Dr. Bob is Robert Hsiung, MD,
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Posted by dessbee on December 11, 2006, at 12:32:43
In reply to Saffron - Anti depressant, posted by dessbee on December 11, 2006, at 7:12:35
The quantity of safranal ranges between 3-7 mg/g of saffron (greec).
So you would roughly need 200 mg of saffron to get 0.7 mg of safranal.
http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2004/52/i14/abs/jf049808j.html
Posted by nolvas on December 11, 2006, at 15:05:01
In reply to Re: Saffron - Anti depressant, posted by dessbee on December 11, 2006, at 12:32:43
Posted by verne on December 11, 2006, at 15:14:33
In reply to Saffron - Anti depressant, posted by dessbee on December 11, 2006, at 7:12:35
Years ago, an ayurvedic doctor prescribed cloves, saffron, and cardamon in tea form.
After reading about saffron, I've decided to give the doctor's recipe another try. Just put in an order at San Francisco Herb Company. Saffron: $33.50 an ounce. Whoa. My total order was $71.83 and shipping was $13.08! Another whoa.
verne
Posted by dessbee on December 11, 2006, at 15:47:11
In reply to Re: Saffron - Anti depressant, posted by dessbee on December 11, 2006, at 12:32:43
I think I am going to cook my favourite salmon-saffron soup :-)
Saffron is quite tastyLD50 is 14 gram so it seems quite safe.
Posted by willyee on December 11, 2006, at 17:42:39
In reply to Re: Saffron - Anti depressant, posted by dessbee on December 11, 2006, at 15:47:11
> I think I am going to cook my favourite salmon-saffron soup :-)
> Saffron is quite tasty
>
> LD50 is 14 gram so it seems quite safe.
>Sorry if im missing anything here,but has anyone actualy tried it,chemicaly it sounds like a very good option.
Posted by verne on December 11, 2006, at 18:16:14
In reply to Re: Saffron - Anti depressant, posted by willyee on December 11, 2006, at 17:42:39
This will be my first time trying saffron in therapeautic doses. I've had a little bit in tea before but nothing serious.
I'm not sure how best to prepare or take it. People cook with it so perhaps a strong tea is the way to go. I'll have to do some research to get the most out of the ounce that's on the way.
verne
Posted by zenhussy on December 11, 2006, at 21:16:34
In reply to Re: Saffron - Anti depressant » willyee, posted by verne on December 11, 2006, at 18:16:14
> I'm not sure how best to prepare or take it. People cook with it so perhaps a strong tea is the way to go. I'll have to do some research to get the most out of the ounce that's on the way.
>
> vernedifferent preparations include: combined with food, combined with other herbs as a tonic, infusions, medicated oil, medicated ghee, in milk with honey, in heated milk
a lot of ayurvedic herbal books will have recipies for preparation as it is a balancing herb for all doshas (kapha, pitta, vata)
Posted by dessbee on December 12, 2006, at 8:02:17
In reply to Re: Saffron - Anti depressant » verne, posted by zenhussy on December 11, 2006, at 21:16:34
In Sweden they make Saffron Bread (also called Lussekatter) as an integral part of the Lucia celibrations. On the 13th of December, St. Lucia is celebrated (tomorrow).Recipe:
http://ourworld.compuserve.com/homepages/gunnar_jonson/lussekat.htmhttp://www.recepten.se/images/recept/0/2/lussekatter_2.jpg
Posted by regis harold on December 16, 2006, at 17:29:30
In reply to Re: Saffron - Anti depressant, posted by verne on December 11, 2006, at 15:14:33
I read about saffron on sjwinfo.org . I tried it for about a week. It had a pretty pronounced effect on me.
My depression seems to be of the atypical subtype. I have had issues with getting good, quality sleep. This has been a long, protracted battle in my life. Generally I feel like hell in the mornings. After taking saffron the night before, I slept about 6 hours (would have preferred 8), but woke up without the irritability and for lack of a better term, "blah-ness", that I usually do. The next day I took some in the morning, and some at night, about a 100mg each time, slept through the night, sleeping a full eight hours.
So, as far as sleeping goes, it was pretty effective. But here's the catch: I had also been taking SJW, and had been for about 3 weeks. I decided that I would stop taking the saffron, and give SJW a good run.
I might try saffron again in the near future. SJW has been effective in combatting the depression, but I feel it also has been making me... pissed off. And I'm not generally a pissed-off kind of person. But I find myself really impatient with myself and others (especially when driving) - which really isn't my personality. Little things seem to set me off. While it's nice not to feel the immense burden that depression heaps on you, it would be great if I weren't annoyed at people all the time.
So once this trial of SJW is over, I may be back to saffron.
Regis
Posted by dessbee on December 17, 2006, at 9:07:59
In reply to Re: Saffron - Anti depressant, posted by regis harold on December 16, 2006, at 17:29:30
SJW has the same effect on me. It improves mood but some how it also increases inner tension, irritability and aggressivity.
Sleep is really important, sometimes i believe depression is actually a sleep disorder. Studies have shown that sleep deprivation disturbs neurogenesis. For sure it disturbs moood, focus and patience.
Posted by Declan on December 17, 2006, at 12:22:00
In reply to Re: Saffron - Anti depressant » regis harold, posted by dessbee on December 17, 2006, at 9:07:59
Yes, why isn't depression a sleep disorder?
Posted by dessbee on December 18, 2006, at 8:14:31
In reply to Re: Saffron - Anti depressant » dessbee, posted by Declan on December 17, 2006, at 12:22:00
Well, I think it is. There seems to be a strong connection. That is probably why SSRI does not work for so many people, it causes sleep deprivation. The difficulty lies in determine which ever came first, sleep disorder or depression.
Found this
"In recent years, researchers established that insomnia and depression are linked, but struggled to determine which came first. Many experts believed that depression caused insomnia until new drugs arrived that improved depression, but not insomnia. The idea that insomnia could be a contributor to, or predictor of, depression gained credence. The study presented today at APSS is the first to establish that insomnia prolongs bouts of sadness, hopelessness and loss of interest in life activities that characterize major depression, making patients less likely to recover. In particular, this first study of patients experiencing major depression found that those suffering from insomnia were over 10 times more likely still to be depressed after 6 months than those without insomnia, and 17 times more likely to remain depressed after a full year. The study concludes that targeting treatment specifically for insomnia will increase both the likelihood and the rate of recovery from major depression."
http://counsellingresource.com/features/archives/2005/drugs/sleep-depression/
Posted by dessbee on December 18, 2006, at 12:55:26
In reply to Re: Saffron - Anti depressant, posted by nolvas on December 11, 2006, at 15:05:01
If Safranal act as an agonist at GABA(A)receptors it probably works through reducing anxiety and improving sleep.
Posted by Declan on December 23, 2006, at 14:17:52
In reply to Re: Saffron - Anti depressant, posted by dessbee on December 11, 2006, at 15:47:11
Salmon saffron soup?
Maybe I can buy saffron in bulk from a local herb supplier.
Posted by dessbee on December 24, 2006, at 14:38:28
In reply to Re: Saffron - Anti depressant » dessbee, posted by Declan on December 23, 2006, at 14:17:52
Saffron quality is serious science
So make sure you get the right quality.
Crocin produce the three things chefs are looking for: aroma (safranal), flavor(picrocrocin) and color (crocin)
Most likely, the more color (crocin) the more safranal.http://www.saffron.com/cons_guide.html
Here is my favourite
French Saffron Salmon Soup600 gram salmon
400 gram shrimp
200 gram dry white wine
2 unions
3 cloves garlic
2 tbs olive oil
1 fennel
1 carrot
5 potatoes
1.2 liter fish bullion
1 tsp thyme
1 can of tomatoes
salt and black pepper
0.5 gram ground saffron
juice from 1/2 orange (you can add some zest if you want to increase taste of orange)Slice union, garlic, fennel, carrots (thin stripes) and potatoes (cubes)
Fry union, garlic, fennel, carrots in olive oil.
Add Potatoes, fish bullion, tomatoes, tyme, salt and pepper
Boil 20 minutes
Add wine, orange juice and saffron
Boil 10 minutes
Add cubes of salmon
Boil/simmer for 3-6 minutes
Peel shrimps and add when soup is ready.(if you want to make a cheaper soup you can just skip shrimps and wine)
Posted by ramsea on December 25, 2006, at 4:52:10
In reply to Re: Saffron - Anti depressant » regis harold, posted by dessbee on December 17, 2006, at 9:07:59
<<<<It improves mood but some how it also increases inner tension, irritability and aggressivity.>>>>
I am very curious--as a bipolar i have experienced dreadful Mixed Episodes, which means meeting the criteria for both mania and depression at the same time. one aspect of this mood state is to be highly energized, with racing thoughts, while also having heaps of inner tension, irritability and agitation (aggression).
can you explain to me how your mood is improved if you at the same time feel these other negative mood conditions? for me an improved mood would not include these conditions, which are real problems as i see it. are you a mix of good feelings, peace, sense of well being--and just sometimes have flares of the negatives? thanks in advance.
ramsea
Posted by dessbee on December 25, 2006, at 7:24:21
In reply to Re: Saffron - Anti depressant, posted by ramsea on December 25, 2006, at 4:52:10
I think your point is well made. My experience is that SJW improves energy level, motivation, circidian rythm, but it also increases inner tension and irritation. Never heard of mixed state, at first I thought you were referring to rapid cycling.
I could be suffering from a depressive mixed state ("major depressive with superimposed hypomanic symptoms") but then again symptoms of depression also include irritability.What medication has improved your symptoms?
Posted by ramsea on December 25, 2006, at 14:35:07
In reply to Re: Saffron - Anti depressant » ramsea, posted by dessbee on December 25, 2006, at 7:24:21
i think sjw is best avoided by the likes of me. it's probably most useful in lethargic depressions, which i rarely get.
medications have proven tricky for me.
although i suffer very acute depressions, it is often overlaid with a variety of manic-type symptoms.
lithium helped me at one point but after a time that backfired.
i can't take any ADs anymore--i always get way too revved up, with either a too intense euphoria or dysphoria background. however, Provigil has helped me at times without adding a manic component.
and low dose seleginine, again on my own addition, has also helped at times. i'm not sure if it still works for me or not--i need to test it.
Tramadol has helped at times--not prescribed for this (i get it for my migraines) but a pleasant side effect has been anti-depressive.sulpride and amisulpride--which i am using now--worked very well for me. i am on 100 mg amisulpride now but my prolactin is a problem and i am going to have to clear my system and try again. i hate to lose it altogether and hope maybe a really dose will help me with dysphoric difficulties and not raise my prolactin. time will tell.
ativan helps with my anxiety and panic disorder, and sometimes seems to stop me from being too irritable and tense inside a speedy, manicky episode.
i wish i had more meds that acted as both calming and motivating. always open to ideas.
Posted by dessbee on December 25, 2006, at 14:51:58
In reply to Re: Saffron - Anti depressant, posted by ramsea on December 25, 2006, at 14:35:07
I think fish oil is the best supplement for inner tension and aggressivity.
It is a great mood stabiliser and has been shown be effective in treating BPD (borderline personality disorder), depression and bipolar disorder.
Posted by ramsea on December 26, 2006, at 8:39:23
In reply to Re: Saffron - Anti depressant » ramsea, posted by dessbee on December 25, 2006, at 14:51:58
i have read this research and as a result take daily fish oil, flaxseed oil, evening primrose oil and eat 12 walnuts. also i try to eat oily fish 1-2 times a week. if the sea were in less trouble i'd feel better about both fish oil and eating fish.
how much do you take daily?
Posted by dessbee on December 26, 2006, at 9:34:20
In reply to Re: Saffron - Anti depressant, posted by ramsea on December 26, 2006, at 8:39:23
I try to eat 200 gram of fatty fish every day. For some reason I get insomnia from pure fish oil; do not tolerate more than 4 gram.
Posted by dessbee on December 26, 2006, at 11:02:46
In reply to Saffron - Anti depressant, posted by dessbee on December 11, 2006, at 7:12:35
It seems like saffron works as an anti-convulsant and effective in the treatment of both depression and epilepsy.
http://www.itmonline.org/arts/saffron.htm
I came to think of similar effects of Lamotrigine (Lamictal); an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is considered to have the most antidepressant potency of BPD drugs.
http://en.wikipedia.org/wiki/Lamictal
Maybe saffron could be used for bipolar disorders as well.
Posted by dessbee on December 27, 2006, at 15:13:29
In reply to Re: Saffron - Anti depressant, posted by dessbee on December 26, 2006, at 11:02:46
Found Hamilton Depression Score from pilot double-blind randomized trial comparing saffron extract (Crocus sativus L.) and imipramine in the treatment of mild to moderate depression.http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=517724&rendertype=figure&id=F1
The whole study:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=517724
Posted by ramsea on January 17, 2007, at 5:55:10
In reply to Re: Saffron - Anti depressant, posted by dessbee on December 27, 2006, at 15:13:29
dessbee,
i have bought fresh saffron. i can take 200 mg of it and do something with it, do you have any recommendations? cook it, eat it cold, eat it hot, brew it 5 minutes or longer in tea, any suggestions? what is the right dose?
and is it still helping you? ramsea
Posted by dessbee on January 26, 2007, at 8:34:47
In reply to Re: Saffron - Anti depressant » dessbee, posted by ramsea on January 17, 2007, at 5:55:10
Hi Ramsea
Sorry, did not see your post until now. I would recommend making tea out of saffron. Dried saffron is easily crumbled/grounded and mixed with 50 ml hot water.
I did not know fresh saffron was available.
I beleive my calculation on 200 mg saffron was based on dried saffron. After the process of roasting, the stigmas of saffron have 1/5 of their original size/weight. So you would roughly need 1/2 - 1 gram of fresh saffron.Saffron needs to be roasted for preservation, so if your fresh saffron is old its chemicals might degrade.
Saffron is often adulterated due to its high price. Roasted saffron is quite easy to identify. Saffron should have a bitter taste of saffron's procrocetin and a distingished smell of safranal. The roasted stigmas should be bright red, dry and brittle. Saffron's crocin should color water golden. Oil content should be low, 0.4 - 1.3% essential oils.
According to some sites it is safe to use in the range up to 1500 mg of dried saffron.Many sites claim saffron is toxic.
http://www.florahealth.com/Flora/home/international/HealthInformation/Encyclopedias/Saffron.asp
But others claim that toxicity is overstated
"Saffron appears to have a very low order of toxicity. It is often said that very high doses of saffron can cause abortion and possible toxic symptoms, but there is no scientific documentation of these supposed effects. However, the so-called meadow saffron, Colchicum autumnale, is highly toxic, and sometimes people mistake one for the other. "
http://healthgate.partners.org/browsing/LearningCenter.asp?fileName=111801.xml&title=Saffron
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