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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by linkadge on May 6, 2006, at 5:08:03
Does anybody know ?
Linkadge
Posted by Larry Hoover on May 6, 2006, at 7:18:53
In reply to what is erythropoietin?, posted by linkadge on May 6, 2006, at 5:08:03
> Does anybody know ?
>
> LinkadgeYes.
Oh dear, you want to know too?
It's a signalling compound. It stimulates erythropoiesis.
Teasing.
It's a glycoprotein (sugar and peptide combined) which is released by the kidneys. Upon being absorbed by bone marrow, it stimulates pluripotent stem cells to differentiate into the final form, erythrocytes, i.e. red blood cells.
Why are you wondering?
Lar
Posted by linkadge on May 6, 2006, at 19:54:22
In reply to Re: what is erythropoietin? » linkadge, posted by Larry Hoover on May 6, 2006, at 7:18:53
I've been compiling a list of agents with neurotrophic potential. This one seemed to come as having ability to promote neurogenesis.
Hmm. Created by the kidneys.
Linkadge
Posted by Larry Hoover on May 7, 2006, at 11:44:00
In reply to Re: what is erythropoietin?, posted by linkadge on May 6, 2006, at 19:54:22
> I've been compiling a list of agents with neurotrophic potential. This one seemed to come as having ability to promote neurogenesis.
Oh? How so?
> Hmm. Created by the kidneys.
>
> LinkadgeThe kidneys regulate all the osmotic gradients in plasma, somehow "integrate" some absolute density value for certain blood cells, are intimately involved in blood pressure regulation. And they send "feedback" information to distant tissues, via modulatory molecules such as this glycoprotein. If you think about it, the kidneys are constantly sending out purchase orders for some number of erythrocytes, to be delivered in two weeks time. There is a statistical likelihood that any individual molecule of this glycoprotein will bind with a distant receptor, so that blood concentration of this modulator is a direct and highly correlated measure of the demand for new erythrocytes.
How does this process influence neurogenesis?
Lar
Posted by linkadge on May 7, 2006, at 15:20:35
In reply to Re: what is erythropoietin? » linkadge, posted by Larry Hoover on May 7, 2006, at 11:44:00
Good question. You know more than I.
http://stroke.ahajournals.org/cgi/content/abstract/35/7/1732
Linkadge
Posted by Larry Hoover on May 8, 2006, at 10:54:03
In reply to Re: what is erythropoietin?, posted by linkadge on May 7, 2006, at 15:20:35
> Good question. You know more than I.
We may know differently, link, but I'd not say more.
> http://stroke.ahajournals.org/cgi/content/abstract/35/7/1732
>
> LinkadgeIt doesn't surprise me in the least that there are complementary increases in related modulatory chemicals. It's interesting that the rats responded to the human chemical. It hints at some central mechanism, in common.
I'd hesitate to consider this as anything more than an interesting observation. It falls far short of what is required to develop any experimental intervention. It's just a "Hmmm" thing.
Lar
Posted by linkadge on May 8, 2006, at 16:40:12
In reply to Re: what is erythropoietin? » linkadge, posted by Larry Hoover on May 8, 2006, at 10:54:03
Not having known what it was, I wasn't sure what to make of the study. If you told me that the substance was contained in breakfast cerial or something, I might be inclined to have another bowl.
Thanks for the info.
Linkadge
Posted by Larry Hoover on May 8, 2006, at 17:05:11
In reply to Re: what is erythropoietin?, posted by linkadge on May 8, 2006, at 16:40:12
> Not having known what it was, I wasn't sure what to make of the study. If you told me that the substance was contained in breakfast cerial or something, I might be inclined to have another bowl.
>
> Thanks for the info.
>
> LinkadgeAhhh. Well said. I got it, now.
No, it's a black market drug. Injectable, only. High end sports cheaters might use it.
Welcome,
Lar
Posted by tealady on May 11, 2006, at 5:34:34
In reply to Re: what is erythropoietin? » linkadge, posted by Larry Hoover on May 8, 2006, at 17:05:11
> > Not having known what it was, I wasn't sure what to make of the study. If you told me that the substance was contained in breakfast cerial or something, I might be inclined to have another bowl.
> >
> > Thanks for the info.
> >
> > Linkadge
>
> Ahhh. Well said. I got it, now.
>
> No, it's a black market drug. Injectable, only. High end sports cheaters might use it.
>
> Welcome,
> Lar
commonly used.. referred to as EPO.. got confused in lectures when they first mentioned EPO:-)Erythropoietin(EPO) is a hormone http://www.medicalnewstoday.com/medicalnews.php?newsid=38894
EPO synthesis is stimulated naturally by low levels of oxygen in the tissues..
Recombinant EPO is a useful alternative to blood transfusions, useful in cancer patients (an alternative to a whole blood transfusion); also aids patients, kidney patients..
An increase in EPO causes an increase increase in immature RBC release from marrow.. leads to incr in %RBC.
unmonitored use--> increase blood viscosity to dangerous levels (H’crit >= approx.60%)
ncreased clotting capacity leading to risk of stroke, heart failure, etc.http://sportsci.org/jour/0002/inbrief.html
http://www.iht.com/articles/2005/09/04/news/lance.phpI've been trying to stay away for a while, and didn't really intend to post. Also I've a huge backlog to catch up on, and exams are coming up around here too.. just checked in to a few places today.
Good to see a lot of posters back again.
I will try to read at least occasionally..and I guess most people know where to find me?
(if not a comment (reply) on tealady-health.blog.co.uk should generate an email to me.. though it doesn't always work. )
This is the end of the thread.
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