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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by LostBoyinNCBecksDark on October 20, 2007, at 20:46:34
In reply to Re: please be civil » LostBoyinNCBecksDark, posted by Dr. Bob on October 20, 2007, at 0:31:00
> > Benzos like klonopin ... play havoc with sleep architecture.
>
>When I mean benzos, I specifically am talking about the traditional benzos that are FDA approved for anxiety/panic such as klonopin or Xanax and not the newer FDA approved for insomnia, hypnotic medications like Ambien or Sonata.
To quote:
http://www.biotext.co.uk/YZ_tXlk.html
In addition, benzodiazepines have other side effects including alteration of sleep architecture (reduction of Stages 1, 3 and 4 and of REM phase sleep, increase of Stage 2) and tolerance/addiction.
From Medline:
"Among the compounds that modulate the benzodiazepine-sensitive GABA(A) receptors, benzodiazepines suppress stage 3-4 sleep, whereas nonbenzodiazepines have no substantial effect on these stages of sleep. Recently, work on GABA agonists indicates that they increase stage 3-4 sleep. This has been demonstrated via sleep-stage scoring as well as with spectral analysis. Further, this increase in stage 3-4 sleep is associated with a decrease in stage 1 sleep and arousals from sleep. Thus, the GABA agonists may not simply promote sleep, but consolidate it as well. The clinical utility of the increase in slow-wave sleep and the sleep consolidation it produces warrants further investigation."
Eric
Posted by Dr. Bob on October 20, 2007, at 20:49:13
In reply to Re: benzos and slow wave sleep, posted by LostBoyinNCBecksDark on October 20, 2007, at 20:46:34
> > > Benzos like klonopin ... play havoc with sleep architecture.
>
> > In addition, benzodiazepines have other side effects including alteration of sleep architecture (reduction of Stages 1, 3 and 4 and of REM phase sleep, increase of Stage 2) and tolerance/addiction."Altering" sleep architecture is one thing, "playing havoc" with it is another...
Bob
This is the end of the thread.
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