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Re: benzos and slow wave sleep

Posted by LostBoyinNCBecksDark on October 20, 2007, at 1:20:59 [reposted on October 20, 2007, at 20:46:34 | original URL]

In reply to Re: please be civil » LostBoyinNCBecksDark, posted by Dr. Bob on October 20, 2007, at 0:31:00

> > Benzos like klonopin ... play havoc with sleep architecture.
>
>

When I mean benzos, I specifically am talking about the traditional benzos that are FDA approved for anxiety/panic such as klonopin or Xanax and not the newer FDA approved for insomnia, hypnotic medications like Ambien or Sonata.

To quote:

http://www.biotext.co.uk/YZ_tXlk.html

In addition, benzodiazepines have other side effects including alteration of sleep architecture (reduction of Stages 1, 3 and 4 and of REM phase sleep, increase of Stage 2) and tolerance/addiction.

From Medline:

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17539704&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

"Among the compounds that modulate the benzodiazepine-sensitive GABA(A) receptors, benzodiazepines suppress stage 3-4 sleep, whereas nonbenzodiazepines have no substantial effect on these stages of sleep. Recently, work on GABA agonists indicates that they increase stage 3-4 sleep. This has been demonstrated via sleep-stage scoring as well as with spectral analysis. Further, this increase in stage 3-4 sleep is associated with a decrease in stage 1 sleep and arousals from sleep. Thus, the GABA agonists may not simply promote sleep, but consolidate it as well. The clinical utility of the increase in slow-wave sleep and the sleep consolidation it produces warrants further investigation."

Eric


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