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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by undopaminergic on February 25, 2023, at 11:02:10
Title: "Lithium and Renal Impairment: A Review on a Still Hot Topic"
https://pubmed.ncbi.nlm.nih.gov/29346806/Full article:
https://sci-hub.ru/https://pubmed.ncbi.nlm.nih.gov/29346806/-undopaminergic
Posted by SLS on February 25, 2023, at 12:10:24
In reply to Another review on lithium and renal impairment, posted by undopaminergic on February 25, 2023, at 11:02:10
One way to mitigate the stress on the kidneys produced by lithium is to take the entire dosage once at night.
Kidney effects with lithium are dosage-dependent.
To treat depression when there is no history of mania, hypomania, or rapid-cyclicity, low-dosage lithium therapy (150-450 mg/day) might be ideal. I don't know if the rate of response for unipolar depression is any different than for bipolar depression. Lithium augmentation of tricyclic and SSRI antidepressant treatments haves been studied since the 1970s. It has the longest history of demonstrating its effectiveness in both unipolar and bipolar depressions. However, I wouldn't be surprised if low-dosage lithium treatment were more effective for bipolar depression than for unipolar depression, but that's just a guess.
- Scott
Posted by Lamdage22 on February 26, 2023, at 6:57:43
In reply to Re: Another review on lithium and renal impairment, posted by SLS on February 25, 2023, at 12:10:24
How about Lithium extended release taken before bed? 225?
Posted by SLS on February 26, 2023, at 10:02:57
In reply to Re: Another review on lithium and renal impairment, posted by Lamdage22 on February 26, 2023, at 6:57:43
> How about Lithium extended release taken before bed? 225?
That nullifies the strategy of taking plain old lithium carbonate. The idea is to take the entire day's dosage once at night. The kidneys see a single brief exposure, and then has the next 24 hours to
"Long-term, low-dose lithium treatment does not impair renal function in the elderly: a 2-year randomized, placebo-controlled trial followed by single-blind extension"
https://pubmed.ncbi.nlm.nih.gov/25093483/
- Scott
This is the end of the thread.
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