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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by SLS on March 3, 2020, at 10:44:44
Zuranolone is a positive allosteric modulator of the GABA-A receptor. I guess it makes the receptor more sensitive and more apt to respond when GABA is received. It is related to brexanolone, the drug infused i.v. to treat post-partum depression. Zuranolone is taken orally.
The early studies of zuranolone reported positive results in treating Major Depressive Disorder and Bipolar Depression in addition to post-partum depression. However, a more recent trial failed to show efficacy for MDD or BD. After the announcement of the study, Sage Pharmaceuticals' stock plummeted on the stock market.
The thing is, the trial lasted for only 15 days. What the hell? I don't know whether or not Sage stopped development, but given the latency of response seen in almost all antidepressants, a 15-day trial is incredibly stupid and criminally irresponsible. If zuranolone is proven to be genuinely useless, it won't be because of the results of this trial. The only thing genuinely useless designing a clinical trial that lasts only 15 days.
Anyway, does anyone know what the drug company plans to do with zuranolone?
- Scott
Posted by Hugh on March 4, 2020, at 11:16:08
In reply to Zuranolone (SAGE-217) - Any information?, posted by SLS on March 3, 2020, at 10:44:44
It looks like Sage hasn't given up on zuranolone for major depression.
"Sage Therapeutics points to patient compliance and selection as factors in its failed trial of SAGE-217."
Posted by SLS on March 4, 2020, at 14:40:08
In reply to Re: Zuranolone (SAGE-217) - Any information?, posted by Hugh on March 4, 2020, at 11:16:08
Thanks, Hugh!
I hope you are doing well. I started taking Marplan two days ago. I hope I can get my doctor to be aggressive with dosage. The last time he worked with it, I think the recommended maximum dosage was 30 mg/day.
> It looks like Sage hasn't given up on zuranolone for major depression.
>
> "Sage Therapeutics points to patient compliance and selection as factors in its failed trial of SAGE-217."
>
> https://scrip.pharmaintelligence.informa.com/SC141741/Sages-Regulatory-Strategy-For-Zuranolone-Remains-Uncertain
>
>
Posted by Hugh on March 4, 2020, at 16:22:41
In reply to Re: Zuranolone (SAGE-217) - Any information? » Hugh, posted by SLS on March 4, 2020, at 14:40:08
You're welcome, Scott. Good luck with Marplan.
I've been feeling better than usual lately. Do you remember posting this?
http://www.dr-bob.org/babble/alter/20160521/msgs/1095022.html
There's a new supplement derived from fish oil called specialized pro-resolving mediators (SPMs). I really like it and I think you should give it a try. It's head and shoulders above any fish oil supplement I've tried before, and I've tried many. Here's an article about it:
https://www.lifeextension.com/magazine/2019/ss/resolve-and-repair-inflammatory-damage
> Thanks, Hugh!
>
> I hope you are doing well. I started taking Marplan two days ago. I hope I can get my doctor to be aggressive with dosage. The last time he worked with it, I think the recommended maximum dosage was 30 mg/day.
>
>
> > It looks like Sage hasn't given up on zuranolone for major depression.
> >
> > "Sage Therapeutics points to patient compliance and selection as factors in its failed trial of SAGE-217."
> >
> > https://scrip.pharmaintelligence.informa.com/SC141741/Sages-Regulatory-Strategy-For-Zuranolone-Remains-Uncertain
> >
> >
>
>
Posted by ed nieg on March 11, 2020, at 3:08:34
In reply to Zuranolone (SAGE-217) - Any information?, posted by SLS on March 3, 2020, at 10:44:44
Hey Scott, can you turn you babblemail on? I'd like to invite you to our chatgroup
Posted by SLS on March 12, 2020, at 21:07:45
In reply to Re: Zuranolone (SAGE-217) - Any information?, posted by ed nieg on March 11, 2020, at 3:08:34
> Hey Scott, can you turn you babblemail on? I'd like to invite you to our chatgroup
I think it's on, isn't it? Let me know.
Thanks for the invitation! I would love to take a look at your chat group.
- Scott
Posted by ed nieg on March 19, 2020, at 20:24:55
In reply to Re: Zuranolone (SAGE-217) - Any information? » ed nieg, posted by SLS on March 12, 2020, at 21:07:45
I apologize for the delay Scott, you should have it in your inbox.
This is the end of the thread.
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