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Zuranolone (SAGE-217) - Any information?

Posted by SLS on March 3, 2020, at 10:44:44

Zuranolone is a positive allosteric modulator of the GABA-A receptor. I guess it makes the receptor more sensitive and more apt to respond when GABA is received. It is related to brexanolone, the drug infused i.v. to treat post-partum depression. Zuranolone is taken orally.

The early studies of zuranolone reported positive results in treating Major Depressive Disorder and Bipolar Depression in addition to post-partum depression. However, a more recent trial failed to show efficacy for MDD or BD. After the announcement of the study, Sage Pharmaceuticals' stock plummeted on the stock market.

The thing is, the trial lasted for only 15 days. What the hell? I don't know whether or not Sage stopped development, but given the latency of response seen in almost all antidepressants, a 15-day trial is incredibly stupid and criminally irresponsible. If zuranolone is proven to be genuinely useless, it won't be because of the results of this trial. The only thing genuinely useless designing a clinical trial that lasts only 15 days.

Anyway, does anyone know what the drug company plans to do with zuranolone?

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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