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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by linkadge on April 5, 2019, at 15:31:40
Earlier this week, there was a story about a Scottish woman with a genetic variant that has resulted in a virtually pain and anxiety free life. I posted the link below. I looked up the variant, and interestingly it was related to the endocannabinoid system. Having used medical marijuana for close to a year now, I was naturally interested. After having taken several psychiatric meds, I found medical cannabis has virtually eliminated treatment resistant GAD.
The woman had a knockout for an enzyme called FAAH. FAAH metabolizes endocannabinoids like anandamide and 2-AG. Because of the genetic variant, the woman had dramatically elevated levels of these endocannabinoids and much reduced pain and anxiety perception. We don't (yet) have FAAH inhibitors available as medications. Some supplements purportedly inhibit it (to a low extent) (i.e. cocoa, Maca). However, I am keeping my eye out for trends in this potentially promising target. What I've noticed about cannabis, is that it relieves anxiety without inducing insomnia or apathy. It also (honestly) feels like it is helping be better "get over" the fears, rather than suppressing them (as the SSRIs feel like they do with me).Thoughts?
https://www.sciencedaily.com/releases/2019/03/190327203450.htm
Linkadge
Posted by sigismund on April 5, 2019, at 16:24:46
In reply to FAAH inhibition - no pain - no anxiety, posted by linkadge on April 5, 2019, at 15:31:40
That was in the news here.....
Posted by sigismund on April 5, 2019, at 16:30:25
In reply to FAAH inhibition - no pain - no anxiety, posted by linkadge on April 5, 2019, at 15:31:40
For me CBD can induce a feeling of psychic fullness (for want of a better description) that is close to that of an opiate.
Posted by linkadge on April 6, 2019, at 18:02:09
In reply to Re: FAAH inhibition - no pain - no anxiety, posted by sigismund on April 5, 2019, at 16:30:25
Yeah, I agree with that. For the duration of the effect, I feel completely normal. No pain, no anxiety, no depression (heaven forbid even feeling 'good').
The existence of an individual who experiences no pain or anxiety (or at least very little), gives me hope that I too can be free.
Linkadge
Posted by SLS on April 6, 2019, at 20:12:34
In reply to Re: FAAH inhibition - no pain - no anxiety » sigismund, posted by linkadge on April 6, 2019, at 18:02:09
> Yeah, I agree with that. For the duration of the effect, I feel completely normal. No pain, no anxiety, no depression (heaven forbid even feeling 'good').
>
> The existence of an individual who experiences no pain or anxiety (or at least very little), gives me hope that I too can be free.
Do you still find it necessary to add some THC?
- Scott
Posted by linkadge on April 7, 2019, at 12:55:19
In reply to Re: FAAH inhibition - no pain - no anxiety » linkadge, posted by SLS on April 6, 2019, at 20:12:34
Hi Scott,
Yes I do. THC gets a bad rap because it can cause a high. But, it is also the cb1 / cb2 agonist. CBD may indirectly interact with these receptors, but it is not a direct agonist.
CB2 agonism is what confers the significant anti-inflammatory effect (especially brain inflammation). CB1 agonism improves mood and can negate aversive effects of stress. CB1 agonist may also have neurotrophic effects.
I probably don't take more than a milligram or two of THC a day (afternoon). But, the effect is potent, and it really seems to attack my cliuster of symptoms (anxiety, depression, insomnia, pain, low appetite, anhedonia, hypersensitivity to light and sound etc).
Posted by Lamdage22 on June 8, 2019, at 12:12:01
In reply to Re: FAAH inhibition - no pain - no anxiety » SLS, posted by linkadge on April 7, 2019, at 12:55:19
Cool. I got really anxious on CBD. I have seen it in the literature that this can happen to a subset of consumers
Posted by sigismund on June 17, 2019, at 16:56:39
In reply to Re: FAAH inhibition - no pain - no anxiety, posted by Lamdage22 on June 8, 2019, at 12:12:01
I have gotten anxious on CBD but I wonder if it was the result of a small (permissible) amount of THC present.
This is the end of the thread.
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