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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by cadburyhesychasm on October 2, 2018, at 7:03:54
Since I have ptsd and bpad1 with severe extreme rage attacks and rage excitation, i believe decreasing substance P might help. Im taking Risp 3Mg plus Lithium SR 800Mg and lithium helps a lot but i would like to try an anti-SP something with it. The one aprepitant is too expensive. Im in India and dont think other pitants are available. so any method to decrease substance p acfivity?
Posted by linkadge on October 2, 2018, at 14:47:10
In reply to Anyway to decrease Substance P indirctly/naturally, posted by cadburyhesychasm on October 2, 2018, at 7:03:54
Ginger root.
Posted by cadburyhesychasm on October 4, 2018, at 4:30:04
In reply to Re: Anyway to decrease Substance P indirctly/naturally, posted by linkadge on October 2, 2018, at 14:47:10
> Ginger root.
Do you have any information on how to dose the ginger safely? And how should I take it, assuming you are talking about fresh root, large quantity might be hard to take or is supplement a way to go? There are a few species right so is the normal Indian one okay? And how does it work to decrease sp, does it bind to tachykinin 1 receptors and if so is there any affinity data available, the relevant molecules does cross the bbb well enough right? and I was wondering lowering SP neurotransmission does it lead to any serious problem if done long term or and little more than needed as normal SP functioning vary from one to other, from what I gleaned in reading.. Thx
Posted by linkadge on October 5, 2018, at 19:33:44
In reply to how does one take the ginger? » linkadge, posted by cadburyhesychasm on October 4, 2018, at 4:30:04
Good questions. Unfortunately, I don't have all the answers. Both ginger root and turmeric have been used as medicines for pain and inflammation for centuries. They possess fairly potent anti-inflammatory effects.
I recall reading that ginger root inhibits substance P, but I don't know the mechanism. It also has calcium channel blocking activity and 5-ht3 antagonist properties. There appears to be some direct or indirect effect on NK1 receptors.
https://www.ncbi.nlm.nih.gov/pubmed/20193490
Ginger root is fairly safe. It has many culinary uses and spice consumption is generally associated with health benefits. Turmeric consumption may be assoicated with lower risk of alzheimers, for instance.If you are concerned about higher doses, you may want to use lower doses as part of a stack (if you can find other substances that inhibit substance P).
Posted by cadburyhesychasm on October 8, 2018, at 4:58:45
In reply to Anyway to decrease Substance P indirctly/naturally, posted by cadburyhesychasm on October 2, 2018, at 7:03:54
I read Gabapentin decreases Substance P due to it's action on ion calcium channels. Anyway I have started Gabapentin at a dose of 300mg tid. because I wanted fo get rid of Risp and though it is crappy as an antimanic it seems to be highly effective for agitation aggression in certain populations and I believe it might help me, I think my symptoms of mainly rage and depression and continuous explosive irritability since 13 years is probably a result of early brain damage and I'm quite convinced about that. It is not purely psych bipolar I think because it is just extreme rage and depression all the time. I had the option of adding Trileptal to Lithium but because of how high dose carbamazepine and aptiom were ineffective I chose gabapentin.
One of the nice things I noted About GBP is that I get a little teary in the eyes. It is because of that I believe it might work, one of the main symptoms is that during rage and nonepisodic constant irritability when treatment is only partially effective or not at all I lose all feelings and become full of only hostility.
I hope I can discontinue Risp except last time I got high blood pressure possibly from Gabapentin hoping if was a fluke.
I have an organic ginger root supplement on the way. I will start it at about 2gm a day. I read dosage should not exceed 10gms.
This is the end of the thread.
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