Psycho-Babble Medication Thread 1092616

Shown: posts 1 to 19 of 19. This is the beginning of the thread.

 

Doctor thinks I need a phenylpiperazine? Help!?

Posted by SouthernFarmer on October 14, 2016, at 18:14:30

Hey, everybody!

I'm not currently on a primary antidepressant. I just got off of Effexor 150mg-- it was hard to do. I just felt like it wasn't working and the sexual side effects were too much-- its friend Pristiq did the same thing. So, I'm undecided about a SSRI/SNRI.

But, I'm depressed!! :( I have a diagnosis of chronic, low-grade dysthymia from an old PDOC of mine.

My current doctor is one of the best in the southern United States. He specializes in general health and is not a PDOC, but he knows more than a lot of PDOCS I've been to

This is what I take:

Psych Meds:

Rexulti 3mg in the morning

Aplenzin which is fancy Wellbutrin 348mg in the morning

Nuvigil 150mg in the morning

Belsomra 10mg at night of course

Gralise which is gabapentin, three time-released 600mg tabs with dinner

Klonopin 2mg twice a day 

Mirapex ER 0.375mg in the morning

Desipramine 150mg at night

Deplin (l-methylfolate) 15mg with breakfast

Buspar 15mg twice a day

Lamictal ER 100mg at night (not bipolar, this helps with depression at this dosage, above this gives me a zombie effect)


Health Meds:

Metformin 1,000mg twice a day

Benztropine 0.5mg twice a day

Byvalson (nebivolol/valsartan) 5mg/80mg night

----------

Rexulti 3mg
Aplenzin 348mg
Nuvigil 150mg
Belsomra 10mg
Gralise 1,800mg
Klonopin 2mg twice a day 
Desipramine 150mg
Deplin (l-methylfolate) 15mg
Lamictal ER 100mg

Metformin 1,000mg 
Benztropine 0.5mg
Byvalson (nebivolol/valsartan) 5mg/80mg 

My doctor thinks a phenylpiperazine would be appropriate due to having less sexual side effects-- nefazodone which is Serzone, Brintellix, or Viibyrd. He said I might have a good reaction to one of these because I did well when Rexulti was added and it is in that class of pharmaceutical chemicals.

Which phenylpiperazine should I add to my meds to help with my chronic, don't want to get out of bed depression? It's better than what it was, I just need more motivation and energy to be honest. I'm 4X better with the meds I'm on. If not a phenylpiperazine, what med should I be on or not be on?

Any help would be greatly appreciated! :)

 

Re: Doctor thinks I need a phenylpiperazine? Help!?

Posted by SouthernFarmer on October 14, 2016, at 18:17:05

In reply to Doctor thinks I need a phenylpiperazine? Help!?, posted by SouthernFarmer on October 14, 2016, at 18:14:30

> Rexulti 3mg
> Aplenzin 348mg
> Nuvigil 150mg
> Mirapex ER 0.375mg
> Belsomra 10mg
> Gralise 1,800mg
> Klonopin 2mg twice a day 
> Desipramine 150mg
> Deplin (l-methylfolate) 15mg
> Lamictal ER 100mg
>
> Metformin 1,000mg 
> Benztropine 0.5mg
> Byvalson (nebivolol/valsartan) 5mg/80mg 

forgot to put the Mirapex in there. It's supposed to give me a little bump in energy-- maybe I need more?

 

Re: Doctor thinks I need a phenylpiperazine? Help!?

Posted by SouthernFarmer on October 14, 2016, at 18:22:30

In reply to Doctor thinks I need a phenylpiperazine? Help!?, posted by SouthernFarmer on October 14, 2016, at 18:14:30

He also said something about tweaking my dosages and meds around and adding the EMSAM patch, and then MAOIs if the patch doesn't work, but he really wants me to try a normal pill first.

I pressured him into talking about how he wanted to treat me going forward.

 

Lou's response- The poison of hate » SouthernFarmer

Posted by Lou Pilder on October 15, 2016, at 9:00:20

In reply to Doctor thinks I need a phenylpiperazine? Help!?, posted by SouthernFarmer on October 14, 2016, at 18:14:30

> Hey, everybody!
>
> I'm not currently on a primary antidepressant. I just got off of Effexor 150mg-- it was hard to do. I just felt like it wasn't working and the sexual side effects were too much-- its friend Pristiq did the same thing. So, I'm undecided about a SSRI/SNRI.
>
> But, I'm depressed!! :( I have a diagnosis of chronic, low-grade dysthymia from an old PDOC of mine.
>
> My current doctor is one of the best in the southern United States. He specializes in general health and is not a PDOC, but he knows more than a lot of PDOCS I've been to
>
> This is what I take:
>
> Psych Meds:
>
> Rexulti 3mg in the morning
>
> Aplenzin which is fancy Wellbutrin 348mg in the morning
>
> Nuvigil 150mg in the morning
>
> Belsomra 10mg at night of course
>
> Gralise which is gabapentin, three time-released 600mg tabs with dinner
>
> Klonopin 2mg twice a day 
>
> Mirapex ER 0.375mg in the morning
>
> Desipramine 150mg at night
>
> Deplin (l-methylfolate) 15mg with breakfast
>
> Buspar 15mg twice a day
>
> Lamictal ER 100mg at night (not bipolar, this helps with depression at this dosage, above this gives me a zombie effect)
>
>
> Health Meds:
>
> Metformin 1,000mg twice a day
>
> Benztropine 0.5mg twice a day
>
> Byvalson (nebivolol/valsartan) 5mg/80mg night
>
> ----------
>
> Rexulti 3mg
> Aplenzin 348mg
> Nuvigil 150mg
> Belsomra 10mg
> Gralise 1,800mg
> Klonopin 2mg twice a day 
> Desipramine 150mg
> Deplin (l-methylfolate) 15mg
> Lamictal ER 100mg
>
> Metformin 1,000mg 
> Benztropine 0.5mg
> Byvalson (nebivolol/valsartan) 5mg/80mg 
>
> My doctor thinks a phenylpiperazine would be appropriate due to having less sexual side effects-- nefazodone which is Serzone, Brintellix, or Viibyrd. He said I might have a good reaction to one of these because I did well when Rexulti was added and it is in that class of pharmaceutical chemicals.
>
> Which phenylpiperazine should I add to my meds to help with my chronic, don't want to get out of bed depression? It's better than what it was, I just need more motivation and energy to be honest. I'm 4X better with the meds I'm on. If not a phenylpiperazine, what med should I be on or not be on?
>
> Any help would be greatly appreciated! :)

Friends,
The combination of the drugs listed by the poster could induce death, life ruining cnditions and addiction.
This is all because when toe drugs are combined , the effects are increased exponentially.
I question the veracity of this post as I do not think that a human being could survive the onslaught to the nervous system that all of those drugs taken together could cause. This leads me to believe that readers could be seriously misled here to their deaths by accepting that those drugs could be taken together as being safe as Mr. Hsiung does not intercede to warn readers that death could be the result from taking these drugs together. This could lead readers to think that the drugs re safer than they really are.
I am asking the poster to send the prescriber's name to Mr. Hsiung and for him to verify the credentials of such. I am also asking children reading here to question as to if you want to be drugged for the rest of your life by reading here thinking that these drugs are safe. They are chemical nerve agents once used as insecticides and in the commission of mass-murder. They sedate the person to take away their humanity and addict so that you keep coming back for more. Life ruining conditions emerge and some are not reversible. In combination, death is a reality as thousands are killed by these drugs each month.
I am prevented from posting here what I think could save your life and lead you out of the darkness of depression and addiction as Mr. Hsiung has posted prohibitions to me. It would come from a Jewish perspective as revealed to me which he prohibits me to post here. He also allows hatred to be posted against me here and allows anti-Semitic propaganda to be posted with impunity from his enforcement policy, as he says he does what will be good for him and his community as a whole, which is the foundation of European Fascism.
But be it as it may be, Mr. Hsiung says that he does what will be good for him and his community as a whole in his thinking which is the same mantra used by European Fascism to commit mass-murder. It is the same thinking used to justify slavery and segregation and infanticide. It turns my stomach to see that type of thinking by a psychiatrist being promoted here as being supportive.
Parents, grab your son, your daughter, out of the hands of the poison of hate being allowed to be seen as supportive here.
Lou

 

Re: Lou's response- The poison of hate

Posted by SouthernFarmer on October 15, 2016, at 14:02:02

In reply to Lou's response- The poison of hate » SouthernFarmer, posted by Lou Pilder on October 15, 2016, at 9:00:20

Dude, I don't need you to post your "advice" LOL!! Like I even read that... get a life.

 

Doctor thinks I need a phenylpiperazine? Help!? » SouthernFarmer

Posted by SLS on October 15, 2016, at 14:28:19

In reply to Re: Lou's response- The poison of hate, posted by SouthernFarmer on October 15, 2016, at 14:02:02

> Dude, I don't need you to post your "advice" LOL!! Like I even read that... get a life.

Hi SouthernFarmer

Dr. Bob recommends:

"Be aware that there may be posters who try to start arguments and upset people ("troll"). Of course, not everyone who starts an argument or upsets someone *intends* to do so. What can be done about those who do? It may be best just not to respond. If you do, please be civil. One possible response is to encourage others not to respond..."

http://www.dr-bob.org/babble/faq.html#civil

Unfortunately, this website has remained unmoderated for quite awhile. However, this might change very soon. Until then, we must tolerate posts similar to the one you reacted to. I hope you are able to gain something from your interactions here.


- Scott

 

Re: Doctor thinks I need a phenylpiperazine? Help!? » SouthernFarmer

Posted by SLS on October 15, 2016, at 14:37:23

In reply to Doctor thinks I need a phenylpiperazine? Help!?, posted by SouthernFarmer on October 14, 2016, at 18:14:30

Hi.

You are taking quite a few drugs. This is not necessarily a bad thing, though. I take six. I am just curious as to whether you have tried to remove any of them. Also, are you certain that the dosages have been optimized?

I am not familiar with the recommendation of using phenylpiperazines as a chemical class of medication to treat depression or anxiety.


- Scott

 

Lou;s response-a life time of misery » SouthernFarmer

Posted by Lou Pilder on October 15, 2016, at 16:12:37

In reply to Re: Lou's response- The poison of hate, posted by SouthernFarmer on October 15, 2016, at 14:02:02

> Dude, I don't need you to post your "advice" LOL!! Like I even read that... get a life.

Friends,
Be not deceived. Notice that my subject line is a response to what the poster wrote. I am not responding to him/her, but to friends.
I am not giving the poster advice but what I wrote could be helpful maybe down the road.
My text is to warn readers of the potential addiction, life ruining conditions and deaths that could result from taking the drugs in question. And also, the fact that what I post here is met with derision and ridicule and contempt as well as defamation against me along with anti-Semitic propaganda being allowed by Mr. Hsiung here. That could steer you away from accepting what I post by creating and developing false opinions and feelings toward me which could seriously mislead you to your deaths by rejecting what I post here.
You see, thousands of people are killed by these drugs every month. If the drugs were not allowed to be promoted here like they are, without the major adverse consequences that the drugs could have, then readers could be seriously misled to think that the drugs are safer than they really are because the psychiatrist chairing this site allows it. That is a powerful influence that could lead young people to their deaths from reading here.
My advice is to make a more-informed decision before you accept what members post here. It could save you from a lifetime of misery
Lou

 

Re: Doctor thinks I need a phenylpiperazine? Help!?

Posted by SouthernFarmer on October 15, 2016, at 16:17:53

In reply to Re: Doctor thinks I need a phenylpiperazine? Help!? » SouthernFarmer, posted by SLS on October 15, 2016, at 14:37:23

> Hi.
>
> You are taking quite a few drugs. This is not necessarily a bad thing, though. I take six. I am just curious as to whether you have tried to remove any of them. Also, are you certain that the dosages have been optimized?
>
> I am not familiar with the recommendation of using phenylpiperazines as a chemical class of medication to treat depression or anxiety.
>
>
> - Scott

I think he just meant those because they're not likely to cause sexual side effects.

https://en.wikipedia.org/wiki/Phenylpiperazine

 

Re: Doctor thinks I need a phenylpiperazine? Help!? » SouthernFarmer

Posted by SLS on October 15, 2016, at 17:25:47

In reply to Doctor thinks I need a phenylpiperazine? Help!?, posted by SouthernFarmer on October 14, 2016, at 18:14:30

> Rexulti 3mg
> Aplenzin 348mg
> Nuvigil 150mg
> Belsomra 10mg
> Gralise 1,800mg
> Klonopin 2mg twice a day 
> Desipramine 150mg
> Deplin (l-methylfolate) 15mg
> Lamictal ER 100mg


What is the Klonopin and Gralise for?

What is the Nuvigil for?

How do you know that Deplin is still providing relief?

Belsomra and Nuvigil might antagonize one another with respect to the orexin system.

I have seen only a few people profit long-term to Mirapex. Are you sure that it is really helping? If energy is a problem, you might do better to use Vyvanse or Focalin. However, if Mirapex is producing unambiguous improvements in anhedonia, it is probably worth keeping. I'm not a big fan of DA pure agonists, though. I'm not sure why. I guess I don't like seeing dopamine receptors downregulated.

I hope you don't get too angry with me: Even though I'm a big proponent of polypharmacy, I can't help but to think that your treatment regime has become a bit messy. My concern is that you might be experiencing cognitive impairments that manifest as brain-fog or a "zombie" effect that are preventing you from increasing the dosages of some drugs; Lamictal and desipramine in particular.

I have just a few comments, although they might not be relevant in your case:

1. The dosage of Rexulti is rather high to treat depression. It might be blunting your affect or giving you brain-fog. 2.0 mg/day should be enough in most cases.

2. The dosage of desipramine is low. If you can tolerate it, you might consider going to 200-300 mg/day.

3. You might try switching from desipramine to nortriptyline. It is milder with respect to side effects, and not as much of a problem with respect to sexual function.

4. Brintellix is a serotonin drug that is known to enhance cognition and should not produce brain-fog. I don't think sexual side effects are a problem.

5. Lamictal dosage is lower than what most people need to glean its full antidepressant potential - 200 mg/day. How long did you stay at 150 mg/day before returning to 100 mg/day? I found that the "zombie" effect or brain fog was only temporary.

I have seen bupropion + lamotrigine + aripiprazole work very well with someone who has unipolar depression and someone else with schizoaffective disorder with depression. Prior to discovering which drugs were working, they had been on very complicated treatment regimes.

I have been fortunate in that my doctor and I have both contributed to a treatment that seems to be working. I have worked with each drug separately to determine its necessity and the lowest effective dosage. Reducing the dosage of any one drug causes me to deteriorate. Going any higher in dosage of some drugs produces unnecessary side effects without further benefit.


- Scott

 

Re: Doctor thinks I need a phenylpiperazine? Help!?

Posted by SouthernFarmer on October 16, 2016, at 12:42:46

In reply to Re: Doctor thinks I need a phenylpiperazine? Help!? » SouthernFarmer, posted by SLS on October 15, 2016, at 17:25:47


> What is the Klonopin and Gralise for?
>

Anxiety. He said the Klonopin can help with mood too?


> What is the Nuvigil for?
>

Energy-- he said it would help wake me up from the Belsomra.


> How do you know that Deplin is still providing relief?
>

I have no idea; it may be placebo.


> Belsomra and Nuvigil might antagonize one another with respect to the orexin system.
>

He says they work together?


> I have seen only a few people profit long-term to Mirapex. Are you sure that it is really helping? If energy is a problem, you might do better to use Vyvanse or Focalin. However, if Mirapex is producing unambiguous improvements in anhedonia, it is probably worth keeping. I'm not a big fan of DA pure agonists, though. I'm not sure why. I guess I don't like seeing dopamine receptors downregulated.
>

Interesting. But I have had problems with addiction in the past, solely with alcohol and pain pills tho, so he is going far out writing what he is writing to me and does a urine screening sometimes on me. I doubt he'd write for an amphetamine, maybe a Ritalin thing.


> I hope you don't get too angry with me: Even though I'm a big proponent of polypharmacy, I can't help but to think that your treatment regime has become a bit messy. My concern is that you might be experiencing cognitive impairments that manifest as brain-fog or a "zombie" effect that are preventing you from increasing the dosages of some drugs; Lamictal and desipramine in particular.
>

Maybe I need to taper off the desi?


> I have just a few comments, although they might not be relevant in your case:
>
> 1. The dosage of Rexulti is rather high to treat depression. It might be blunting your affect or giving you brain-fog. 2.0 mg/day should be enough in most cases.
>

It didn't seem to do much at 2.0mg just like Abilify didn't do anything until 15mg and I was on 20mg./day.

> 2. The dosage of desipramine is low. If you can tolerate it, you might consider going to 200-300 mg/day.
>

May not even need it? Or try nortrip.

> 3. You might try switching from desipramine to nortriptyline. It is milder with respect to side effects, and not as much of a problem with respect to sexual function.
>

I'll bring this up. Thinking I don't need a TCA. Prolly need less drugs.

> 4. Brintellix is a serotonin drug that is known to enhance cognition and should not produce brain-fog. I don't think sexual side effects are a problem.
>

I'm interested in it.


> 5. Lamictal dosage is lower than what most people need to glean its full antidepressant potential - 200 mg/day. How long did you stay at 150 mg/day before returning to 100 mg/day? I found that the "zombie" effect or brain fog was only temporary.
>

I went to 250mg -- found it dulled me and cognitively blurred me, but the lower dosages seemed to give me energy and an antidepressant effect.


> I have seen bupropion + lamotrigine + aripiprazole work very well with someone who has unipolar depression and someone else with schizoaffective disorder with depression. Prior to discovering which drugs were working, they had been on very complicated treatment regimes.
>

Basically what I'm on except I'm on Rexulti instead of Abilify.


> I have been fortunate in that my doctor and I have both contributed to a treatment that seems to be working. I have worked with each drug separately to determine its necessity and the lowest effective dosage. Reducing the dosage of any one drug causes me to deteriorate. Going any higher in dosage of some drugs produces unnecessary side effects without further benefit.
>

I'm afraid, but ready to make some moves-- tapering off things, but I need something primary like a SSRI/SNRI to really get me out of this slump-- might try Trintellix.


>
> - Scott

Good advice. Thanks!

 

Re: Doctor thinks I need a phenylpiperazine? Help!?

Posted by Jonhed on October 16, 2016, at 16:52:55

In reply to Doctor thinks I need a phenylpiperazine? Help!?, posted by SouthernFarmer on October 14, 2016, at 18:14:30

Can i ask what your diagnose and "main problem" is?
I'm certainly not anti meds but your list is impressing..

When i got clean the first time I had a compareble list of medications to yours, and I was feeling fine in all the brain fog that comes with that amount of different chemicals in your body.
Unfortunately/fortunately I got dystonia from haldol (haloperidol) and what's enough freaked out after month dealing with that to stop all the meds from one day to another, bad idea, but when my head cleared up I understood one thing that may not be true for you but it was for me,. That 10 different chemicals is to much, period. It's gotten way out of hand and the doctor who treats you better be an pioneer in his work to know what remains effective and not with chemicals that may synergize or may antagonize the other med.

Do NOT take this as a "stop all your meds" post, see it as a "think through what is important and not, and most importantly: what's your goal in this?

Like, if anxiety is the primary problem, then you should have something for anxiety (like klonopin, though it is a though one to taper later on), some antidepressant like trintellix or whatsoever fits you, and if that's not enough you may add an mood stabilizer or a low(!) dose ap/aap.

Okey I see the point in having many medicines (like 6) in low doses to eliminate the side effects and so on. But try to stay as clear in your mind as possible, and find 2-3 real good medicines that fits you.

I will gladly give you tips as I am an addict to (stimulants and opiates), and I relapse a lot so I can give you the bad ideas if you want them to! Hehe.

This is my tip, and my tips are equal good to my friends at this forum but from other angles.
Pick and choose from everyone's tips here and be selfish, don't do nothing to please no one as it is your life.

Welcome to this forum :-)

Ps. All of the posters here knows about pharmaceuticals and the chemistry behind them, if not, they have very long experience from these medications, as I do think you have to.

And one last thing.. mirapex are going to make you tired after a while. I would up the nuvigil to 300 as it's not addictive.

 

Re: Doctor thinks I need a phenylpiperazine? Help!?

Posted by Christ_empowered on October 17, 2016, at 18:13:58

In reply to Doctor thinks I need a phenylpiperazine? Help!?, posted by SouthernFarmer on October 14, 2016, at 18:14:30

you take a lot of meds. I'm not an MD, but...wow.

I take 4 meds for what is diagnosed as severe bipolar I. Abilify, trileptal, lamictal, and wellbutrin. I take Neurontin as needed.

What about...rexulti, a higher dose of wellbutrin, lamictal, xanax xr (preferably am and PM, but...whatevah) and either keep the nuvigil or switch to ritalin or focalin?

xanax can help some people with depression...at the very least, its not likely to cause or worsen depression to the same extent as, say, Klonopin. I would think the xr should ideally be done 2x daily so you don't wake up with anxiety, although I imagine any bzd at night time would do the trick.

I think ritalin or focalin, so me kinda all day preparation, might be better for depression, unless you really like the NuVigil. I mean...ritalin's been around forever, so there's more data behind it (although...the data behind uppers in depression isn't all that great. Just sayin').

Gabapentin is great for some people, so I guess you'd wanna keep that, too.

Just my suggestions. I wish you well.

 

christ empovered, a question!

Posted by Jonhed on October 18, 2016, at 5:18:59

In reply to Re: Doctor thinks I need a phenylpiperazine? Help!?, posted by Christ_empowered on October 17, 2016, at 18:13:58

Can you manage abilify withuout akathisia?

I'm so frustrated that I can't seem to manage ap/aap's, none.

 

Re: Doctor thinks I need a phenylpiperazine? Help!? » Jonhed

Posted by SLS on October 18, 2016, at 5:53:37

In reply to Re: Doctor thinks I need a phenylpiperazine? Help!?, posted by Jonhed on October 16, 2016, at 16:52:55

Did you see the article I posted to you regarding the treatment of akathisia?

Saphris is less likely to produce akathisia at the same rate as Abilify. For me, the mild akathisia I experienced with Abilify disappeared completely withing a week. I started at 20 mg/day. If Abilify (aripiprazole) helps improve symptoms, and you are looking for a replacement drug, you might try Rexulti (brexpiprazole) instead. On paper, it should produce akathisia at a reduced rate. I haven't seen enough people on it to know for sure. I would still give Saphris a try if you haven't already. If it is going to work for depression, it should do so within a week provided you are taking a therapeutic dosage.

Regarding the article I posted, it is proposed that drugs that block serotonin 5-HT2a receptors can act to reduce akahisia. Abilify is not very potent at blocking these receptors, so you might try adding low-dose Remeron (mirtazapine) as a remedy for Abilify-induced akathisia.


- Scott

 

Re: Doctor thinks I need a phenylpiperazine? Help!?

Posted by SLS on October 18, 2016, at 6:02:22

In reply to Re: Doctor thinks I need a phenylpiperazine? Help!? » Jonhed, posted by SLS on October 18, 2016, at 5:53:37

I forgot to mention that nortriptyline, a tricyclic antidepressant (TCA), also blocks 5-HTa receptors, but I don't know to what extent. I'll try to find out. There is also Periactin (cyproheptadine).


- Scott

__________________


> Did you see the article I posted to you regarding the treatment of akathisia?
>
> Saphris is less likely to produce akathisia at the same rate as Abilify. For me, the mild akathisia I experienced with Abilify disappeared completely withing a week. I started at 20 mg/day. If Abilify (aripiprazole) helps improve symptoms, and you are looking for a replacement drug, you might try Rexulti (brexpiprazole) instead. On paper, it should produce akathisia at a reduced rate. I haven't seen enough people on it to know for sure. I would still give Saphris a try if you haven't already. If it is going to work for depression, it should do so within a week provided you are taking a therapeutic dosage.
>
> Regarding the article I posted, it is proposed that drugs that block serotonin 5-HT2a receptors can act to reduce akahisia. Abilify is not very potent at blocking these receptors, so you might try adding low-dose Remeron (mirtazapine) as a remedy for Abilify-induced akathisia.
>
>
> - Scott

 

Doctor thinks I need a phenylpiperazine? - Error

Posted by SLS on October 18, 2016, at 6:35:06

In reply to Re: Doctor thinks I need a phenylpiperazine? Help!?, posted by SLS on October 18, 2016, at 6:02:22

Sorry for the error. 5-HTa is supposed to be 5-HT2a. I corrected it in the passage below.

> I forgot to mention that nortriptyline, a tricyclic antidepressant (TCA), also blocks 5-HT2a receptors, but I don't know to what extent. I'll try to find out. There is also Periactin (cyproheptadine).

Both amitriptyline and nortriptyline block 5-HT2a receptors about as much as mirtazapine and cyproheptadine. Of course, using Zyprexa (olanzapine) or clozapine (Clozaril) are options if an antipsychotic is indicated for mania or a schizoid disorder. These two drugs are generally the best for psychosis, but the worst for weight-gain and the development of diabetes. Glucophage (metformin) might counteract these side effects. Its use for this remediation is somewhat controversial, but I think it is worth a try.

Interestingly, as a TCA, amitriptyline is unique in that it acts as an agonist at TrkA and TrkB receptors, and thus promotes BDNF neurotrophism. It is thought that this action produces its superior antidepressant effect relative to imipramine.


- Scott


__________________


> > Did you see the article I posted to you regarding the treatment of akathisia?
> >
> > Saphris is less likely to produce akathisia at the same rate as Abilify. For me, the mild akathisia I experienced with Abilify disappeared completely withing a week. I started at 20 mg/day. If Abilify (aripiprazole) helps improve symptoms, and you are looking for a replacement drug, you might try Rexulti (brexpiprazole) instead. On paper, it should produce akathisia at a reduced rate. I haven't seen enough people on it to know for sure. I would still give Saphris a try if you haven't already. If it is going to work for depression, it should do so within a week provided you are taking a therapeutic dosage.
> >
> > Regarding the article I posted, it is proposed that drugs that block serotonin 5-HT2a receptors can act to reduce akahisia. Abilify is not very potent at blocking these receptors, so you might try adding low-dose Remeron (mirtazapine) as a remedy for Abilify-induced akathisia.
> >
> >
> > - Scott

 

Re: Doctor thinks I need a phenylpiperazine? - Error

Posted by Christ_empowered on October 18, 2016, at 7:31:48

In reply to Doctor thinks I need a phenylpiperazine? - Error, posted by SLS on October 18, 2016, at 6:35:06

I take a lot of vitamins with my Rx pills...Orthomolecular. B-vitamins, in particular, can reduce adverse effects from the pills. massive doses of b6 have been used both in akathisia and in tardive dyskinesia, to good effect. I take a high potency b-complex (b-100) plus 3grams niacinamide (b3), plus lots of other things. That seems to keep adverse effects to a minimum...

...weirdly enough, I got akathisia off zyprexa (even on klonopin), but not abilify. My personal, wild *ss guess is that there's a subset of people/"patients" who do better with d2 partial agonism than with the old school d2 blockers. Anyway...I used to get a tremor from abilify, especially with an anticonvulsant in the mix, but now...no stiff gait, no tremor, no nervousness, no major cognitive dulling...

..and I'm on 30mgs/day. I was on 15, but then I went off and promptly freaked out and now I take 30. Have for years.

High dose B3 works on GABA, kinda sorta like a mild BZD drug, among other effects. Its used as part of a mix for the prevention and also treatment of tardive dyskinesia.

Hope this helps.

 

Re: Doctor thinks I need a phenylpiperazine? - Error

Posted by Jonhed on October 18, 2016, at 8:17:47

In reply to Re: Doctor thinks I need a phenylpiperazine? - Error, posted by Christ_empowered on October 18, 2016, at 7:31:48

That is good information from you both, thank you so much.

I will immediately start with my vitamin b complex again, it was soothing indeed.

And to Scott, I read the article and it was very interesting!

I'm sorry for hijacking the thread, it happens so often and it seems that it comes by itself.


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