![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Horse on July 12, 2016, at 19:29:15
I have no idea what HCN channels are, but....
http://medicalxpress.com/news/2016-07-antidepressant.html#nRlv
Posted by PeterMartin on July 13, 2016, at 0:47:18
In reply to HCN channels? A novel target, posted by Horse on July 12, 2016, at 19:29:15
> I have no idea what HCN channels are, but....
>
> http://medicalxpress.com/news/2016-07-antidepressant.html#nRlvHa! I just came here to post this. Very interesting even though any practical use of this new research is surely years off.....
Posted by linkadge on July 13, 2016, at 19:52:20
In reply to Re: HCN channels? A novel target, posted by PeterMartin on July 13, 2016, at 0:47:18
Yes. I have no idea what HCN channels are either. Perhaps some kind of ion channel (aka sodium channels?). I will look into this.
Linkadge
Posted by jonhed on July 15, 2016, at 14:29:00
In reply to HCN channels? A novel target, posted by Horse on July 12, 2016, at 19:29:15
And here i am thinking that i knew most of the receptors and targets but this i have never heard of.
This is soon on the market and i can't wait!!:
https://en.wikipedia.org/wiki/Allopregnanolone
It's extensive studies on it in sweden and in america too, i think this is the best alternative we're going to have :-)
Read and be amazed! (if you want to read more than just wikipedia there is a lot of studiesd on it on other sites to!
Posted by SLS on July 15, 2016, at 16:56:13
In reply to HCN channels? A novel target, posted by Horse on July 12, 2016, at 19:29:15
> I have no idea what HCN channels are, but....
>
> http://medicalxpress.com/news/2016-07-antidepressant.html#nRlvThis is as crappy article. It gives no information at all to explain how inhibiting HCN channels affects the excitability of neurons, and what the net effect is in hippocampal activity and the formation of memories.
My rudimentary understanding of HCN from reading Wiki this indicates that these channels are openings that allow for any cation type (non-selective)to travel through them.
K+
Na+
Ca2+The opening of the channels between adjacent neurons are dependent on the voltage state of a presynaptic neuron and the presence of cyclic nucleotides (cAMP; gAMP). This connection between membranes allows for a group of connected neurons to act as "pace-makers", especially in the heart. HCN channels in the central nervous system (CNS) act to modulate the strength of connectivity between neurons at the synapse via dendritic spines, which are short buds that grow from the dendrite to the pre-synaptic neuron. The waxing and waning of localized dendritic spines creates the plasticity that allows the brain to process and retain information.
- Scott
Posted by jonhed on July 15, 2016, at 17:30:44
In reply to Re: HCN channels? A novel target, posted by SLS on July 15, 2016, at 16:56:13
Memantine is Ca2+ voltage gate dependent, that's why you can't get the pcp-effects from it.
It can never fully block the nmda-receptors as pcp and ketamine can.
Cause it's voltage gate dependent right?If it weren't for that, it would have been a powerful drug that would have no therapeutic use at all.
That's how i understands it, have i got it right then?
(i understand more but it's so hard to write in english what i know exactly, and it's late in the night.)
What else is voltage gate dependent?
Isn't calcium channel blockers (heart medication) that to?
And most of the epilepsy medicines are to i think.But what would be the use of hcn channels?
Can dopamine flow trough Ca2+ in a voltage gated manner or what?
Is that even possible?If it's possible for nmda and glutamate, then it should be possible for every neurotransmitter and it should open up for a lot of new medicines that are impossible to abuse, or am i'm completely out in the blue?
I can read about it but it's so much right now that if someone knows
Posted by Horse on July 15, 2016, at 18:20:35
In reply to Re: HCN channels? A novel target, posted by SLS on July 15, 2016, at 16:56:13
So then, the antidepressant affect of lamotrigine? At least partially, although I don't understand the science enough to evaluate anticonvulsants....
Posted by jonhed on July 16, 2016, at 8:46:13
In reply to Re: HCN channels? A novel target, posted by Horse on July 15, 2016, at 18:20:35
Yeah maybe that's why, this is kind of hard core science so i'm not 100% sure either.
cause calcium channel blockers that are voltage gate dependent do not have antidepressant effects, or have they?
Posted by Horse on July 16, 2016, at 15:05:46
In reply to Re: HCN channels? A novel target, posted by jonhed on July 16, 2016, at 8:46:13
I think only some AED's have this effect. There may be others, but after I followed up on my hunch, I read that lamotrigine does. Sometimes I thought my response to lamotrigine was placebo, but after maybe six months, and my steadily improving and stable mood, I decided MAYBE lamotrigine had something to do with it.
Posted by jonhed on July 17, 2016, at 16:59:04
In reply to Re: HCN channels? A novel target » jonhed, posted by Horse on July 16, 2016, at 15:05:46
Yeah i don't think that lamotrigine is placebo, i was doing well on it to.
Are you on it now?Memantine is voltage gate dependent to and gives me a very good effect. And it's nice to have womething that you can't abuse :-)
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.