Posted by jonhed on July 15, 2016, at 17:30:44
In reply to Re: HCN channels? A novel target, posted by SLS on July 15, 2016, at 16:56:13
Memantine is Ca2+ voltage gate dependent, that's why you can't get the pcp-effects from it.
It can never fully block the nmda-receptors as pcp and ketamine can.
Cause it's voltage gate dependent right?If it weren't for that, it would have been a powerful drug that would have no therapeutic use at all.
That's how i understands it, have i got it right then?
(i understand more but it's so hard to write in english what i know exactly, and it's late in the night.)
What else is voltage gate dependent?
Isn't calcium channel blockers (heart medication) that to?
And most of the epilepsy medicines are to i think.But what would be the use of hcn channels?
Can dopamine flow trough Ca2+ in a voltage gated manner or what?
Is that even possible?If it's possible for nmda and glutamate, then it should be possible for every neurotransmitter and it should open up for a lot of new medicines that are impossible to abuse, or am i'm completely out in the blue?
I can read about it but it's so much right now that if someone knows
poster:jonhed
thread:1090460
URL: http://www.dr-bob.org/babble/20160713/msgs/1090535.html