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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by SLS on October 1, 2015, at 14:04:44
I tried Marplan once, but gave up on it rather quickly. I was taking 40 mg/day.
Does anyone have experience with high-dose Marplan? Someone here is doing well at dosages at or above 90 mg/day. I am thinking about discontinuing Parnate so that I can try Brintellix. I would consider retrying Marplan, but I don't know how high one can go with it.
Any and all comments are welcome.
Thank you.
- Scott
Posted by PeterMartin on October 1, 2015, at 21:13:50
In reply to High-dose Marplan (isocarboxezid)? Anyone?, posted by SLS on October 1, 2015, at 14:04:44
Didn't you have an interaction w/ Marplan and Lithium?
I'm currently taking 40mg of Marplan. I tried going up to 50 this month (w/o asking my doc) and randomly noticed my bp was pretty high (140/95). So I have to figure that out before I try a higher dose. I'm hoping the high bp was related to Prune juice/Wild Blueberries I'd consume in excess but I'm dropping back on Marplan until it comes down. I always seem to have BP reactions to things....I couldn't take Parnate due to extreme spikes after each dose.
I did see that one post of someone taking 100mg+ of Marplan. I'm interested as well to hear from people who've gone beyond the recommended 60mg.
Posted by bleauberry on October 2, 2015, at 13:29:07
In reply to High-dose Marplan (isocarboxezid)? Anyone?, posted by SLS on October 1, 2015, at 14:04:44
Scott you've handled high doses of heavy duty stuff in the past so if that is any indication then maybe you can go for really high doses without much worry. Marplan used to get high comments here from a few people some years back.
Posted by SLS on October 2, 2015, at 16:24:21
In reply to Re: High-dose Marplan (isocarboxezid)? Anyone?, posted by bleauberry on October 2, 2015, at 13:29:07
> Scott you've handled high doses of heavy duty stuff in the past so if that is any indication then maybe you can go for really high doses without much worry. Marplan used to get high comments here from a few people some years back.
Now, all I have to do is sell my doctor on the idea.
:-)
- Scott
Posted by Uncouth on October 5, 2015, at 22:03:43
In reply to Re: High-dose Marplan (isocarboxezid)? Anyone? » bleauberry, posted by SLS on October 2, 2015, at 16:24:21
Scott, why would you go off of Parnate to try Brintellix? Have you heard differentially of THAT much benefit Brintellix can provide? I'm assuming it's the 5ht7 antagonism..,but your on abilify already right? If more of that is what your seeking have you tried adding low dose amisulpride?
How high have you pushed the Parnate? I am just escalating (again) after having to stop 120mg Parnate over two weeks two months ago. I will continue to push it as high as I need to this time around as I finally detected partial effectiveness when I hit 120mg before surgery.
Oh and I tried Marplan earlier this year in between Nardil and Parnate....due to Nardil weight gain. I think I went as high as 80 or 90, and it didn't feel as effective as Nardil but I wish I had pushed the dose.
Posted by SLS on October 6, 2015, at 0:41:07
In reply to Re: High-dose Marplan (isocarboxezid)? Anyone? » SLS, posted by Uncouth on October 5, 2015, at 22:03:43
Hi, Uncouth.
> Scott, why would you go off of Parnate to try Brintellix? Have you heard differentially of THAT much benefit Brintellix can provide?
I am stuck. I guess I want what I once had. I might change my mind along the way if I become desperately depressed again. I am down from 120 mg/day to 100 mg/day to 80 mg/day. I'll probably stay there for a few days.
I have been impressed by the few success stories I have seen here regarding Brintellix. Apparently, when it works, it works well. My doctor has had a few of his TRD patients respond to it. My short term plan is to discontinue Parnate and try Brintellix. I should probably have a colonoscopy while I'm off of a MAOI.
When it worked, Nardil made me feel better than Parnate does. I don't know. Maybe high dosages of another hydrazine would give me more motivation and resolve anhedonia, two symptoms that Parnate doesn't help with.
> I'm assuming it's the 5ht7 antagonism..,but your on abilify already right?
Yes. :-) You really know your stuff. Brintellix is also a full agonist of 5-HT1a receptors rather than a partial agonist as is Abilify.
5-HT reuptake inhibitor
5-HT1a full agonist
5-HT1d partial agonist
5-HT3 antagonist
5-HT7 antagonist
5-HT1b antagonstI will also consider switching from Abilify to Vraylar. I am guessing that it should increase motivation and mental energy more than Abilify due to its higher selectivity for dopamine D3 receptors as a partial agonist.
> If more of that is what your seeking have you tried adding low dose amisulpride?
That's an interesting idea. Thanks.
> How high have you pushed the Parnate?150 mg/day. It didn't help any more than 120 mg/day of Parnate. The thing is, one can experience a brief improvement in vegetative symptoms whenever the dosage is increased. Perhaps this is due to its stimulant-like properties. This improvement can deceive one into dosage escalation. I will let you know how I feel as I reduce the dosage. There will probably be a lag time between dosage reduction and relapse, as it may take a few days for new MAO to be synthesized.
> I am just escalating (again) after having to stop 120mg Parnate over two weeks two months ago. I will continue to push it as high as I need to this time around as I finally detected partial effectiveness when I hit 120mg before surgery.
>
> Oh and I tried Marplan earlier this year in between Nardil and Parnate....due to Nardil weight gain. I think I went as high as 80 or 90, and it didn't feel as effective as Nardil but I wish I had pushed the dose.Did Marplan help at all? If so, which symptoms did it improve?
What is the longest time you remained at one dosage of Parnate? Adding lithium 300 mg/day or Lamictal might help.
I will play with resveratrol and N-acetylcysteine (NAC) at some point.
<sigh>
- Scott
Posted by uncouth on October 6, 2015, at 17:11:23
In reply to Re: High-dose Marplan (isocarboxezid)? Anyone? » Uncouth, posted by SLS on October 6, 2015, at 0:41:07
Why resveratrol?
I can't say Marplan did anything so great. I can't recall if I noticed anything compared to Nardil except maybe normalization of appetite but it seemed to be worse for mood.
Longest I've ever been on Parnate at a single dose is probably a month. I was only on 120mg for I think two weeks. Interesting what you say about dosage escalation and parnate. I've been going up at 10mg a week, so maybe once i hit 120mg I should slow down?
I've been on lithium before but never with Parnate. Might be something to consider.
In terms of Brintellix--have you heard/read anything that it is "easier" on bipolars (I am BP2, never have such great responses long term to SS/NRIs as they seem to lift mood but eventually push into hypomanic like symptoms and in the long term what seems like dopaminergic reduction and a sort of numbed out apathetic/amotivational state....have you heard brintllex is better in this regard than standard SS/NRIs?)
Curious about Vraylar as well though I can't remember where I read it and maybe it was the other new A/P that just got approved....and maybe it won't matter but there was something about it being more on the "antagonistic" side of partial agonism at D2/D3 than abilify. Have you heard/read the opposite? If so I might look into it. Just concerned about weight gain as I get it even on abilify.
good luck.
Posted by Horse on October 27, 2015, at 1:30:20
In reply to High-dose Marplan (isocarboxezid)? Anyone?, posted by SLS on October 1, 2015, at 14:04:44
> I tried Marplan once, but gave up on it rather quickly. I was taking 40 mg/day.
>
> Does anyone have experience with high-dose Marplan? Someone here is doing well at dosages at or above 90 mg/day. I am thinking about discontinuing Parnate so that I can try Brintellix. I would consider retrying Marplan, but I don't know how high one can go with it.
>
> Any and all comments are welcome.Hi Scott,
I didn't think it was available in the US.
Best wishes for your med changes.
>
> Thank you.
>
>
> - Scott
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