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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 25. This is the beginning of the thread.
Posted by joe f on August 15, 2015, at 19:13:21
does it work and is it a low dose
Posted by phidippus on August 16, 2015, at 16:24:03
In reply to 100 mg of seroquel for sleep, posted by joe f on August 15, 2015, at 19:13:21
Yes and that is a low dose.
Eric
Posted by Lamdage22 on August 19, 2015, at 12:49:29
In reply to Re: 100 mg of seroquel for sleep » joe f, posted by phidippus on August 16, 2015, at 16:24:03
Yes
Posted by chumbawumba on August 21, 2015, at 0:04:33
In reply to 100 mg of seroquel for sleep, posted by joe f on August 15, 2015, at 19:13:21
When I was taking seroquel 100mg as monotherapy it knocked me out like an elephant gun. I can't recall how many times I fell aslepp on the couch. When it started to kick in I could barely walk.
Now I take it in combination with moclobemide and the moclobemide seems to counteract the sedation quite a bit.
Posted by SLS on August 21, 2015, at 5:53:37
In reply to Re: 100 mg of seroquel for sleep, posted by chumbawumba on August 21, 2015, at 0:04:33
> When I was taking seroquel 100mg as monotherapy it knocked me out like an elephant gun. I can't recall how many times I fell aslepp on the couch. When it started to kick in I could barely walk.
>
> Now I take it in combination with moclobemide and the moclobemide seems to counteract the sedation quite a bit.How long have you been taking moclobemide for? Is it helping?
Thanks.
- Scott
Posted by Poet on August 21, 2015, at 10:10:52
In reply to 100 mg of seroquel for sleep, posted by joe f on August 15, 2015, at 19:13:21
I take 50mg and it takes about an hour to work, so I would think that 100mg would put you right to sleep. And as others have said it's a low dose.
Poet
Posted by chumbawumba on August 21, 2015, at 17:24:23
In reply to Re: 100 mg of seroquel for sleep » chumbawumba, posted by SLS on August 21, 2015, at 5:53:37
>
> How long have you been taking moclobemide for? Is it helping?
>
> Thanks.
>
>
> - ScottI've taken moclobemide for almost three years now. It's probably been the best of all the antidepressants I've taken and I've taken most of them except for the irreversible MAOIs. At first there was a very positive effect. No sexual side effects. The only side effect was insomnia.
Over time however the benefits have diminished and my dose has been increased from 300 to 900 mg. And even at that relatively high dose I'm barely functioning. It keeps from being actively suicidal and that's about it. I think I'm going to lobby my Doctor to put me on Parnate. Although the Parnate insomnia scares me.
Posted by SLS on August 21, 2015, at 19:30:19
In reply to Re: 100 mg of seroquel for sleep, posted by chumbawumba on August 21, 2015, at 17:24:23
> I think I'm going to lobby my Doctor to put me on Parnate. Although the Parnate insomnia scares me.
I would hate to see you look at insomnia as being a deal-breaker. It should be looked at as being something to be treated as aggressively as the depression itself.
The first time I was exposed to a combination of Parnate and desipramine, I got absolutely no sleep for days until my doctor was aggressive enough to combine Halcion and Ativan as a sleep aid.
- Scott
Posted by chumbawumba on August 21, 2015, at 22:02:24
In reply to Re: 100 mg of seroquel for sleep » chumbawumba, posted by SLS on August 21, 2015, at 19:30:19
>
> I would hate to see you look at insomnia as being a deal-breaker. It should be looked at as being something to be treated as aggressively as the depression itself.
>
> The first time I was exposed to a combination of Parnate and desipramine, I got absolutely no sleep for days until my doctor was aggressive enough to combine Halcion and Ativan as a sleep aid.
>
>
> - Scott
>Was the Halcion and Ativan necessary for the duration of your treatment with Parnate or did the insomnia eventually go away?
Posted by SLS on August 21, 2015, at 22:06:50
In reply to Re: 100 mg of seroquel for sleep » SLS, posted by chumbawumba on August 21, 2015, at 22:02:24
>
> >
> > I would hate to see you look at insomnia as being a deal-breaker. It should be looked at as being something to be treated as aggressively as the depression itself.
> >
> > The first time I was exposed to a combination of Parnate and desipramine, I got absolutely no sleep for days until my doctor was aggressive enough to combine Halcion and Ativan as a sleep aid.
> >
> >
> > - Scott
> >
>
> Was the Halcion and Ativan necessary for the duration of your treatment with Parnate or did the insomnia eventually go away?I wouldn't know. I never attempted to discontinue them while on the Parnate and desipramine combination. Unfortunately, my doctor at the time had me discontinue antidepressants, but I relapsed. Nothing has worked well since. Parnate + desipramine doesn't work anymore.
- Scott
Posted by chumbawumba on August 21, 2015, at 22:18:00
In reply to Re: 100 mg of seroquel for sleep » chumbawumba, posted by SLS on August 21, 2015, at 22:06:50
> I wouldn't know. I never attempted to discontinue them while on the Parnate and desipramine combination. Unfortunately, my doctor at the time had me discontinue antidepressants, but I relapsed. Nothing has worked well since. Parnate + desipramine doesn't work anymore.
>
>
> - ScottGeez, that's really a shame. I feel for you. I know what it's like to feel unfixable. I'm placing a lot of hope in trying an irreversible MAOI. I don't know what I'll do if it doesn't help. It's very hard to face each day with soul crushing pain.
Posted by SLS on August 22, 2015, at 5:43:46
In reply to Re: 100 mg of seroquel for sleep » SLS, posted by chumbawumba on August 21, 2015, at 22:18:00
> Geez, that's really a shame. I feel for you. I know what it's like to feel unfixable. I'm placing a lot of hope in trying an irreversible MAOI. I don't know what I'll do if it doesn't help. It's very hard to face each day with soul crushing pain.
"Unfixable" is a good word to describe how I feel right now. In 1985, one of my doctors, Baron Shopsin, said that I would never get well. He said that something was wrong with my receptors. I never accepted this until recently. Still, I carry on with some weird sort of drive that I don't understand. What better choice do I have?
The MAOI diet restrictions have never been determined definitively. Sometimes, I think some of it is based on superstition rather than scientific evidence. Nobody has thought to test various foods on rats during chronic MAOI exposure. The following link will bring up what is, in my opinion, a reasonable list of foods to avoid.
http://www.dr-bob.org/babble/20010814/msgs/75408.html
- Scott
Posted by phidippus on August 23, 2015, at 17:38:14
In reply to Re: 100 mg of seroquel for sleep » chumbawumba, posted by SLS on August 21, 2015, at 19:30:19
How is combining two benzodiazapines useful for insomnia?
Eric
Posted by SLS on August 23, 2015, at 18:03:34
In reply to Re: 100 mg of seroquel for sleep » SLS, posted by phidippus on August 23, 2015, at 17:38:14
> How is combining two benzodiazapines useful for insomnia?
>
> EricHalcion (triazolam) is the most potent hypnotic benzodiazepine. It will knock out an elephant. However, it has a half life of 1 1/2 hours, and can allow for rebound awakenings. Ativan, with its longer half life, is given to prevent rebound awakenings and produce an extended period of sleep. Of course, there may be additive or synergistic hypnotic effects at first when the two drugs are dosed together.
I wonder how combining Ambien and Ativan would affect someone with severe insomnia. The principle should be the same. I haven't looked into this.
- Scott
Posted by phidippus on August 23, 2015, at 18:15:05
In reply to Re: 100 mg of seroquel for sleep » chumbawumba, posted by SLS on August 22, 2015, at 5:43:46
>He said that something was wrong with my receptors. I never accepted this until recently.
That's a strange hypothesis and I don't think its acceptable. Receptors are too malleable and they're only a cog in the mechanics of the brain.
Perhaps some part of your brain may not be functioning properly, perhaps Area 25. You might need deep brain stimulation.
>I carry on with some weird sort of drive that I don't understand.
You must enjoy the small things in life
or
You don't want to die.
>What better choice do I have?
That is an excellent question. What are the possible choices?
Eric
Posted by phidippus on August 23, 2015, at 18:36:52
In reply to Re: 100 mg of seroquel for sleep » phidippus, posted by SLS on August 23, 2015, at 18:03:34
I read a study somewhere midazolam was as strong as triazolam...
When you dealt with insomnia with triazolam and lorazepam, did you have marked somnolence during the day?
Eric
Posted by Christ_empowered on August 24, 2015, at 9:38:15
In reply to Re: 100 mg of seroquel for sleep » SLS, posted by phidippus on August 23, 2015, at 18:15:05
I guess combining two BZD drugs would be like a modern day version of Tuinal?
Posted by SLS on August 24, 2015, at 21:33:43
In reply to Re: 100 mg of seroquel for sleep, posted by Christ_empowered on August 24, 2015, at 9:38:15
triazolam = sleep initiation
lorazepam = sleep maintenance
- Scott
Posted by Christ_empowered on August 25, 2015, at 7:04:32
In reply to Re: 100 mg of seroquel for sleep » Christ_empowered, posted by SLS on August 24, 2015, at 21:33:43
I honestly didn't know they still Rx'd Halcion on a regular basis. I've seen a Halcion Rx once, and that was to pre-medicate for a dentist's appointment.
I always wanted to try one, ever since reading "American Psycho" .
Posted by phidippus on August 25, 2015, at 10:54:23
In reply to Re: 100 mg of seroquel for sleep » Christ_empowered, posted by SLS on August 24, 2015, at 21:33:43
Isn't there something better than lorazepam, since it alters sleep structure.?
Eric
Posted by phidippus on August 25, 2015, at 11:03:39
In reply to Re: 100 mg of seroquel for sleep, posted by Christ_empowered on August 25, 2015, at 7:04:32
>I've seen a Halcion Rx once, and that was to pre-medicate for a dentist's appointment.
I hope they didn't fall asleep.
Eric
Posted by SLS on August 25, 2015, at 13:43:51
In reply to Re: 100 mg of seroquel for sleep » SLS, posted by phidippus on August 25, 2015, at 10:54:23
> Isn't there something better than lorazepam, since it alters sleep structure.?
>
> EricThis was 1987.
Do the Z drugs affect sleep architecture?
- Scott
Posted by phidippus on August 25, 2015, at 14:50:49
In reply to Re: 100 mg of seroquel for sleep » phidippus, posted by SLS on August 25, 2015, at 13:43:51
I found:
"At 150 min after Tmax, both ZOL and BTM significantly increased stage 2 (S2), and ZOL showed significantly longer slow wave sleep (SWS; stage 3+4) as compared to BTM." BTM=brotizolam. ZOL=zolpidem
and
"sleep cycles structure showed that the increase of stages 3 and 4 occurred only during the first part of the night." (with Zolpidem).
Zolpidem does alter sleep structure but mainly by increasing stage 3 and 4 sleep. I don't know about the other z drugs.
Eric
Posted by Sheilac on August 28, 2015, at 12:54:15
In reply to 100 mg of seroquel for sleep, posted by joe f on August 15, 2015, at 19:13:21
I used to take 50mg and it knocked me out. Was great for sleep.
Posted by Lamdage22 on September 2, 2015, at 13:25:15
In reply to Re: 100 mg of seroquel for sleep, posted by Sheilac on August 28, 2015, at 12:54:15
> I used to take 50mg and it knocked me out. Was great for sleep.
Haha.
This is the end of the thread.
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