![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by stan_the_man70 on July 30, 2015, at 12:31:52
got this from the riordan clinic website in Kansas
https://riordanclinic.org/2014/03/supplements-accelerate-benzodiazepine-withdrawal-a-case-report-and-biochemical-rationale/also posted on orthomolecular.org
http://www.orthomolecular.org/resources/omns/index.shtml--------------------------
Supplements Accelerate Benzodiazepine Withdrawal: A Case Report and Biochemical RationaleOrthomolecular Medicine News Service
by W. Todd Penberthy, PhD and Andrew W. Saul(OMNS March 18, 2014) A middle-aged male had success rapidly reducing fast-acting alprazolam (Xanax) dosage by taking very high doses of niacin, along with gamma aminobutyric acid (GABA) and vitamin C. The individual had been on 1 mg/day Xanax for two years, a moderate dose but a long duration. As a result, he had been presenting increased anxiety, personality changes, and ringing in the ears (tinnitus), all side effects likely due to long-term alprazolam use. Typical withdrawal from this drug would involve substitution medication, about a 10% dose reduction per week, and take a matter of months.[1] A fast withdrawal is a 12.5 to 25% reduction per week.[2] On very high doses of niacin, vitamin C, and also GABA, this individual reported being able to cut the dose 60% down to 0.4 mg in one week. The dose was reduced by 90% (to 0.1 mg/day) in less than a month. He reported residual anxiety, but that it was substantially less than when fully medicated. After a total of five weeks, the medication intake was zero, with minimal residual anxiety.
Dosage
Niacin doses were between 6,000 and 12,000 mg/day. The individual reported reduced anxiety when taking the highest levels of niacin. Bowel-tolerance levels of vitamin C were taken daily, along with 750 mg of GABA twice daily. The individual also drank a quart of beet/cabbage soup broth daily for the first week, took 400 mg magnesium citrate/day, and took sublingual methylcobalamin (hi-absorption B-12), 5,000 mcg twice a week. During the initial total withdrawal from alprazolam, intake of GABA was 750 mg three times daily. The patient experienced side effects of daily but manageable anxiety. He also reported occasional nausea, possibly attributable to the GABA and almost certainly attributable to the extremely high niacin intake. He experienced increased frequency of urination, especially at night. Evening niacin doses as inositol hexaniacinate (a semi-sustained release, no-flush niacin) reduced nighttime urination. The individual used regular flush niacin about three-quarters of the time; inositol hexaniacinate constituted the balance. Dosage was divided into eight to ten 1,000 mg 8-10 such doses in 24 hours. Niacinamide was specifically not used, as its nausea threshold is low (under 6,000 mg day).
Niacin Mechanism of Action
Dr. Abram Hoffer had observed beneficial anticonvulsant activity by performing coadministration of niacinamide with anticonvulsants to treat epileptics in the early 1950s (personal communication). The dosage of the anticonvulsant could be reduced by 50% when 1,000-2,000 mg of niacin was administered with each meal. Hoffer noted that this was beneficial to patients because at the lower dose of anticonvulsant they were not nearly as drowsy.
In the late 1970s niacinamide was reported to be a ligand for the benzodiazepine receptor with physiological activities. Later studies suggested that the effect is not based on a direct specific interaction between niacinamide and benzodiazepine receptors.[3-5] However, ten years later a completely different benzodiazepine-binding receptor was identified in the peripheral nervous system.[6] This peripheral benzodiazepine receptor, known as translocator protein (TSPO), can modulate neurosteroids, which can alter neuronal excitability through interactions with GABA neurotransmitter ion channels. This can enhance GABA receptor function.[7]
A common question is, how exactly GABA taken orally can help if it does not readily cross the blood brain barrier (BBB). While GABA receptors are primarily known for their CNS locations and functions, there are also GABA receptors in the liver, immune cells, and lung cells that are accessible to bind GABA without crossing the BBB. The peripheral benzodiazepine receptor TSPO, as mentioned above, is one example. This can activate neurons in peripheral nerves that ultimately affect the CNS as well.
This case report described however, showed a positive result when using niacin. The common theme here is nicotinamide adenine dinucleotide (NAD) since both niacin and niacinamide are converted to NAD by the body. This indicates that therapeutic benefit is most likely being mediated via the increase in NAD levels, not through activation of the high affinity niacin G-protein coupled receptor, GPR109a, which niacinamide does not bind. NAD is used in over 450 reactions by the body, which is more than any other vitamin-derived molecule. The following are just a small list of the pathways that are dependent on it: drug/xenobiotic metabolism, steroid metabolism, basic glycolysis/TCA ATP generation, and many more.
These pathways are quite complicated, but one thing is for certain. We are susceptible to niacin deficiency as exemplified by the deadly pellagra epidemics in the first two decades of the 20 century, which killed over 100,000 people in the southern United States. Due to this epidemic, President Roosevelt commissioned epidemiologists to begin working on this serious problem. Many people with skin disorders were placed in sanitariums because common subclinical pellagra symptoms are dermatitis and sensitivity to sunlight.
Niacin is thought to help maintain homeostasis of neurotransmitters that are commonly unbalanced in the brains of those with anxiety [8], and it may also alter the metabolism of Xanax. As a primary participant in the hydroxylation reaction characteristic of phase 1 drug-metabolizing enzymes, NAD can speed up the metabolism of toxic waste products arising from the metabolism of the foreign alprazolam molecule.[8,9]
Specifically, Xanax is metabolized by the enzyme CYP3A4. Xanax induces CYP3A4 expression, meaning the body responds to Xanax administration by making more of the enzyme that degrades the Xanax molecule. The enzymatic reaction is dependent on the presence of the cofactor NAD, which is derived from niacin in the diet. The drug metabolizing enzyme reaction cannot proceed without the presence of all 3: the substrate (Xanax), the enzyme (CYP3A4), and the cofactor in NAD (derived from niacin). Individuals taking Xanax are likely to have high levels of the drug and the enzyme. But the metabolic reaction utilizing this enzyme that degrades the drug is commonly limited by insufficient levels of the cofactor, NAD.
By administering high doses of niacin, the concentration of NAD is increased, which then accelerates the rate of the drug-metabolizing reaction, ultimately clearing the drug from the body faster. The niacin flush / vasodilation is likely to aid in delivery to otherwise hard to reach anatomical locations as well as increase physical flow of the drug metabolites.
GABA
GABA seems likely to be a safer replacement to withdraw from as compared to simple weaning off of alprazolam. Using GABA is an orthomolecular approach, involving manipulating a substance normally present in the body. Ingested GABA will be metabolized by the normal endogenous mechanisms, for which humans have evolved to control properly. GABA will likely be cleared better than alprazolam and not be afflicted with the non-specific affects associated with the foreign molecule that GABA is.
GABA is one of the main inhibitory neurotransmitters in the brain. Oral GABA does not cross the blood brain barrier (BBB), but yet GABA oral ingestion still exerts the calming effect that is attributed to GABA activity. Low GABA is detectable in Xanax withdrawal, while plenty of GABA enables one to feel calm and to sleep better. GABA has been successfully used to assist with Xanax withdrawal .[10]
Another molecule, picamilon, is a niacin molecule bonded to GABA as one single molecule that may be useful. Picamilon crosses the BBB and then is broken down to niacin and GABA. Picamilon can help restore GABA receptor levels.
Also GABA is degraded into succinate, which in its own right can provide a significant source of energy as it directly enters the TCA cycle. Even though the exact reason is unknown, people taking GABA have noticed calming effects. The placebo effect may be responsible for part of the benefit. However, it is likely at high doses some GABA does get into the CNS.
Vitamin C
Because ascorbate in high doses is a strong antitoxin [11], it is considered to be an important inclusion. Flu-like symptoms common in benzodiazepine withdrawal may be ameliorated with vitamin C. Ascorbate also provides support for the liver, ranging from 500 mg/day preventing fatty buildup and cirrhosis to 5,000 mg of vitamin C per day appearing to actually flush fats from the liver, to 50,000 mg/day eliminating jaundice in under a week. [12]
Magnesium
Magnesium depletion is common in nearly all examples of people ingesting drugs. Thus, magnesium supplements are helpful. Nightly Epsom salt baths and 400 mg of magnesium citrate, once in the morning and once in the afternoon can facilitate a smooth transition away from alprazolam. Also realize that if you desire to measure your magnesium levels, be sure to do either the red blood cell test or the ionized magnesium test. However, do not test for serum magnesium levels. Serum magnesium concentrations are so tightly controlled that the results are invariably normal, so the test has been removed from the standard blood test suite.
Summary
Collectively this case history and biochemical rationale indicate that very high doses of niacin, GABA, and vitamin C together may greatly speed detox and reduce withdrawal symptoms from alprazolam. Additional therapeutic trials are warranted. It is emphasized that every person is different and that this experience may not be applicable to all. Alprazolam is a seriously addictive drug and withdrawal symptoms may be severe. Every individual should work closely with their healthcare provider.
(Dr. Todd Penberthy is a research consultant, medical writer and niacin researcher. A list of his recent papers is posted at http://www.cmescribe.com/resume/ Andrew W. Saul, OMNS Editor, is the general editor of the comprehensive textbook, The Orthomolecular Treatment of Chronic Disease, to be published in late June, 2014. http://www.doctoryourself.com/treatmentreviews.html )
Posted by stan_the_man70 on July 30, 2015, at 12:40:14
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
------------------reference quote
http://www.madinamerica.com/2014/03/herbs-supplements-foods-can-aid-withdrawal-symptoms/
--------------------end quoteHerbs, Supplements, Foods That Can Aid in Withdrawal Symptoms
By Chaya Grossberg
Featured Blogs March 14, 2014
When one is coming off of psychiatric pharmaceuticals, it's common to experience withdrawal induced anxiety, panic and psychosis. Here are some tips to help calm your body.
Herbs to help with withdrawal induced anxiety/insomnia/psychosis:
Herbs are best absorbed as tincture or tea (rather than capsules or pills). If possible, buy (or forage or grow) loose organic herbs and steep your own tea. Organic bag tea is also fine but use 2 tea bags and steep for awhile to get a stronger tea.
Chamomile, Angelica, Passionflower, Skullcap, Lemon Balm, Licorice, Lavender (also good as essential oil), Valerian (can help with sleep just be careful not to get dependent on it), St. Johns Wort (need to take regularly to experience results), Meadow Sweet (also for headaches), Ginko Biloba, Kava Kava (good for sleep), Hops, Melissa, Rescue Remedy/Rescue Sleep/Homeopathic sleep aid.
Essential Oils: Basil, Lavender, Frankincense, Orange, Melissa, Eucalyptus, Peppermint, Geranium, Rose. Many other oils are good for anxiety. These are my favorites for calming.
Supplements (take high quality food based when possible as liquid/chewable for better absorption): B Vitamins, Vitamin D (sublingual), Vitamin C (take powder but too much can cause digestive upset so mostly get it from fruit), Calcium, Magnesium, Melatonin (for sleep).
Synthetic vitamins should be used with care, similar to drugs. Avoid taking a lot of new ones all at once and/or stopping a supplement regimen suddenly as most contain synthetic chemicals and mild toxins and should be withdrawn from slowly. If you use high quality, you won't need as much. Intuition helps when choosing which ones to take. Trust your instincts, be moderate, get as much as possible from food and broth.
Foods: fats (a spoonful or 2 of olive oil/sesame oil/coconut oil can help with insomnia/anxiety), proteins (if not vegetarian red meat is helpful though too much can increase aggression in some people; good in Winter and for anxiety and fatigue), lots of vegetables.
Protein powders from whey/hemp/pea/rice (not soy protein isolate). Fruit and honey at bedtime. Whole milk goat dairy products if dairy is tolerated.
Probiotics: miso, sauerkraut, kimchee, yogurt, kefir, cultured foods.
Bone broth: Cook organic bones in a crock pot or on the stove on low for a day or so with a dash of vinegar. Recipes available online to get ideas. Great source of calcium, magnesium, B Vitamins and soothing for digestion. Drink this daily with salt and add it to cooking.
Also: warm baths with Epsom salt/sea salt/baking soda and essential oils before bed or when sleep is interrupted. Rub coconut oil on feel/scalp/body for relaxation at bedtime.
With withdrawal induced panic and psychosis, remember it will pass. Do your best with self care and know that once the drug has been mostly detoxified, you will return to homeostasis. Usually the acute phase of withdrawal lasts less than a week with each reduction. Go slower if needed.
This is not medical advice, simply ideas I and others have found helpful. There will always be more things to try, as well as differing viewpoints and nutritional outlooks so I mostly recommend things I've used myself and know others have used that have been of benefit. This is not meant as a "better" diet or the "right" diet. There is no right diet. Every single food, herb and supplement will be undesirable or intolerable or cause an allergic reaction to someone. Every person is different in constitution, sensitivity and ability to tolerate different foods and substances. Please share what has been helpful for you.
--------------------Chaya Grossberg/Chaya Grossberg
All of Us or None of Us: Chaya questions the idea that some of us are "mentally ill" and others of us are not. She shares lessons learned through coaching people coming off psychiatric drugs and/or looking for alternatives to taking them.
Posted by Christ_empowered on July 30, 2015, at 16:56:01
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
hey man. I do a DIY orthomolecular in addition to meds. I like the link, btw.
I'm surprised she was on that much niacin! I take niacinamide, because of the flush and all. I only take 3 grams/day, plus a lot of other stuff...
Anyway, thanks for this.
Posted by jpa on July 30, 2015, at 17:47:24
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
Very interesting material. Thanks for posting. I just talked to my doctor this morning and we worked out a schedule to get off the remainder of the meds I'm on (phenibut). I've reached the end of the line with medication in treating my insomnia. Problem is supplements and vitamins do not offer consistent relief. So it looks like CBT is the only thing left to try. Next several months will be difficult getting off the phenibut. I just hope I don't have to go on sick leave while I get off phenibut...why is going to bed and falling asleep such a dam hard thing to do???? Not fair.
Posted by rjlockhart37 on July 31, 2015, at 0:02:45
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
phenobarbital is excellant for benzo withdrawl, but it's got the label of being a barbiturate, its old drug but it still takes the symptoms away with out getting that xanax high......
but a good thing for withdrawl with no doctor's care is valerian root, magnesium, and kava.....those work vary well for taking anxiety away including shakes from benzo withdrawl
that and nuerontin
pheno itself really is not euphoric at all......just sedation and maybe anxiety relief and sedation
Posted by Hugh on August 1, 2015, at 8:05:12
In reply to Re: anyone heard of riordan clinic?, posted by jpa on July 30, 2015, at 17:47:24
> So it looks like CBT is the only thing left to try.
Have you tried Belsomra (suvorexant)? If CBT doesn't help, there are other options for insomnia. Deep TMS can help.
So can neurofeedback. And a type of CES called Nexalin can help insomnia.
Posted by jpa on August 1, 2015, at 9:46:42
In reply to Re: anyone heard of riordan clinic? » jpa, posted by Hugh on August 1, 2015, at 8:05:12
Great suggestions. I'll do little more research nexalin...have you had any success with this technology?
Posted by Hugh on August 1, 2015, at 11:55:50
In reply to Re: anyone heard of riordan clinic? » Hugh, posted by jpa on August 1, 2015, at 9:46:42
I'm interested in trying Nexalin, but the closest provider is a few hundred miles from me. I have had some success with neurofeedback. This study found it to be a very effective treatment for insomnia:
Posted by jpa on August 1, 2015, at 17:33:25
In reply to Re: anyone heard of riordan clinic? » jpa, posted by Hugh on August 1, 2015, at 11:55:50
Did some research. Some CES unites (like Ultra) can be had for as low as $280 USD. It sounds like a promising treatment, if only for the placebo effect it might have. If it actually works, double bonus. I'm thinking of buying a unit.
Anybody else with personal experience with CES??
Posted by Hugh on August 2, 2015, at 1:52:19
In reply to Re: anyone heard of riordan clinic? » Hugh, posted by jpa on August 1, 2015, at 17:33:25
> Anybody else with personal experience with CES??
My Sota Bio Tuner (BT7) has three settings -- energizing, relaxing and sleep. The energizing program made me feel anxious. The relaxing and sleep programs made me feel calm, but over a period of a few months, they became less and less effective. My brain became habituated to them. Apparently, habituation is a big problem with CES devices.
I belong to some of the neurofeedback groups on Yahoo. Some neurofeedback clinicians have tried using Alpha Stim (probably the best-known CES device) with their patients. The clinicians say that it works for a while, but then their patients become habituated to it. Some of the neurofeedback clinicians who have used Alpha Stim are far more enthusiastic about Nexalin. It appears to be more effective than other forms of CES, and so far habituation hasn't been a problem. The disadvantage with Nexalin is that you can't buy one for personal use. You have to go to Nexalin provider to try it.
Posted by jpa on August 2, 2015, at 6:52:56
In reply to Re: anyone heard of riordan clinic? » jpa, posted by Hugh on August 2, 2015, at 1:52:19
okay, thanks. So it appears it will be no more effective over the long-term than medications. But I may get a unit to help in the short-term as I work off the remainder of my medication. I'm looking at buying the Ultra machine. Do you have any views on Ultra?
By the way, do they have Nexalin providers in Canada?
Posted by stan_the_man70 on August 2, 2015, at 9:58:45
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
------------quote reference
http://www.orthomolecular.org/resources/omns/v10n18.shtml
--------------end quoteFOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, October 27, 2014
Niacin and Schizophrenia: History and Opportunity
by Nick Fortino, PhD Candidate------------------excerpt
Evidence for the Niacin Treatment of SchizophreniaVitamin B3 as a treatment for schizophrenia is typically overlooked, which is disconcerting considering that historical evidence suggests it effectively reduces symptoms of schizophrenia, and has the added advantage, in contrast to pharmaceuticals, of mild to no adverse effects (22-35). After successful preliminary trials treating schizophrenia patients with niacin, pilot trials of larger samples commenced in 1952-reported in 1957 by Hoffer, Osmond, Callbeck, and Kahan. Dr. Abram Hoffer began an experiment involving 30 patients who had been diagnosed with acute schizophrenia. Participants were given a series of physiological and psychological tests to measure baseline status and were subsequently assigned randomly to treatment groups. Nine subjects received a placebo, 10 received nicotinic acid, and 11 received nicotinamide (the latter two are forms of vitamin B3). All participants received treatment for 42 days, were in the same hospital, and received psychotherapy from the same group of clinicians. The two experimental groups were administered three grams of vitamin B3 per day. Each of the three treatment groups improved, but the two vitamin B3 groups improved more than the placebo group as compared to baseline measures. At one year follow up, 33% of patients in the placebo group remained well, and 88% of patients in the B3 groups remained well. These results inspired many subsequent trials, and those that replicated the original method produced similarly positive results.
-------------end excerpt
Posted by stan_the_man70 on August 2, 2015, at 10:08:17
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
-----------------quote reference
http://www.orthomolecular.org/resources/omns/v10n14.shtml
---------------end quoteFOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, September 3, 2014The Clinical Impact of Vitamin C:
My Personal Experiences as a PhysicianCommentary by Thomas E. Levy, MD, JD
-----------------------excerpt
The validation and enormous importance of much of this test tube research came from the work of Frederick Klenner, MD in North Carolina. His clinical experience demonstrated how vitamin C was just as effective in the body as in the test tube in neutralizing or negating the toxic impact of whatever toxin the patient was exposed to. Snake venom, heavy metals, pesticides, cyanide, alcohol, carbon monoxide were all neutralized. The results that Dr. Klenner reported with infections were also astounding, as vitamin C, properly administered, proved to be the ultimate virucidal agent, curing all acute viral infections. These viral infections remain incurable by the standard approaches of modern medicine today. Furthermore, Klenner showed that vitamin C was also very effective in the treatment of many non-viral infections, improving the efficacy of treatment by antibiotics and other medications administered today. While I have seen but a fraction of the types of conditions that Dr. Klenner described, I fully believe the accuracy of everything Dr. Klenner published. I have applied vitamin C treatment to many patients with conditions similar to those treated by Dr. Klenner, along with several other conditions that Dr. Klenner did not have the opportunity to treat. With the perspective of this clinical experience, I have little reason to doubt any of the fabulous outcomes that he reported.What I Have Witnessed
I recall here some of the most dramatic anecdotes about the healing power of vitamin C in the hope of conveying to the reader what an extraordinary addition it can be to the clinical options of any medical doctor. Shortly after the vitamin C book was completed and published, I began a limited clinical practice with a few colleagues. The circumstances were pretty much ideal for me, as I was able to give or prescribe intravenous vitamin C as needed.
Severe Influenza
H1N1 Influenza
Pulmonary Embolism
West Nile Virus
Infectious Mononucleosis
Acute Lyme Disease
Chronic Lyme Disease
-----------------------end excerpt
Posted by stan_the_man70 on August 2, 2015, at 10:12:59
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
----------------quote reference
http://www.orthomolecular.org/resources/omns/v10n12.shtml
-------------end quoteFOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, July 25, 2014Laropiprant is the Bad One; Niacin is/was/will always be the Good One
by W. Todd Penberthy, PhD
-------------------------excerpt
Why the B Vitamins Are So ImportantThe B vitamins were discovered due to terrible nutritional epidemics: pellagra (niacin/vitamin B3 deficiency) and beriberi (thiamine/vitamin B1 deficiency). We are very sensitive to a deficiency of niacin. Over 100,000 people died in the American south in the first two decades of the 20th century due to a lack of niacin in their diet. It was perhaps the worst nutritional epidemic ever observed in modern times, and was a ghastly testimony to how vulnerable the human animal is to niacin deficiency. The pellagra and beriberi epidemics took off shortly after the introduction of processed foods such as white rice and white flour. Poor diets, mental and physical stresses, and certain disease conditions have all been proven to actively deplete nicotinamide adenine dinucleotide (NAD) levels, causing patients to respond favorably to greater than average niacin dosing.
How is it possible that niacin can be useful for many different conditions? It seems too good to be true. The reason is that niacin is necessary for more biochemical reactions than any other vitamin-derived molecule: over 450 different gene-encoded enzymatic reactions (UniproKB database of the Swiss Institute of Bioinformatics; (Penberthy 2013)). That is more reactions than any other vitamin-derived co-factor! Niacin is involved in just about every major biochemical pathway. Some individuals, who have a genetically encoded amino acid polymorphism within the NAD binding domain of an enzyme protein, will have a lower binding affinity for NAD that can only be treated by administering higher amounts of niacin to make the amount of NAD required for normal health. Genetic differences such as these are why many individuals require higher amounts of niacin in order for their enzymes to function correctly (Ames 2002).
-------------------------end excerpt
Posted by stan_the_man70 on August 2, 2015, at 10:18:30
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
---------------quote reference
http://www.orthomolecular.org/resources/omns/v09n23.shtml
----------------end quoteFOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, October 30, 2013Treating ADHD with Vitamin B-3 (Niacinamide)
by Andrew W. Saul, Editor
---------------------excerpt
"Some patients have a response to niacinamide therapy which seems to be the clinical equivalent of 'decreased running' observed in experimental animals. When these animals are deprived experimentally of certain essential nutriments, they display 'excessive running,' or hyperkinesis. When these deficient animals receive the essential nutriments in sufficient amounts for a sufficient period of time, there is exhibited a marked 'decrease in running.'"The benefit is so profound, said Dr. Kaufman, that a person receiving niacinamide treatment "may wonder whether or not his vitamin medications contain a sedative. . . Analysis of his history indicates that prior to niacinamide therapy he suffered from a type of compulsive impatience, starting many projects which he left unfinished as a new interest distracted him, returning perhaps after a lapse of time to complete the original project. Without realizing it, he was often careless and inefficient in his work, but was 'busy all the time.'"
-------
Dr. Kaufman's observation that niacinamide is an effective remedy for hyperactivity and lack of mental focus is very important. With attention deficit hyperactivity disorder, orthodox medicine seems unwilling even to admit nutrient deficiency as a causal factor, let alone a curative one. Such nutritional information as does make news generally stays far from the headlines, unless, of course, it is critical of vitamins. The most widely publicized vitamin therapy trials tend to be low-dose, worthless, negative, or all three. Mass media attention to a given nutritional research study appears to be inversely proportional to its curative value.
---------------------end excerpt
Posted by stan_the_man70 on August 2, 2015, at 10:22:15
In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52
-----------------quote reference
http://www.orthomolecular.org/resources/omns/v09n09.shtml
-----------------end quoteFOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, May 14, 2013Antioxidants: The Real Story
Biased Researchers; Parroting Pressby Gert E. Schuitemaker, PhD
-----------------excerpt
How antioxidants workOxygen is necessary for life, but on the other hand it inevitably generates reactive molecules throughout all the tissues of the body. These free radicals are dangerous for any cell because they can damage essential molecules such as DNA and the enzymes necessary for proper function of the cell. Antioxidants capture these reactive free radicals and safely convert them back to normal. Although the body does produce antioxidant molecules, these work together with antioxidants that are delivered by the diet, mainly from fruit and vegetables but also from supplements.
Antioxidants can be divided into several groups. In addition to the 'classic' antioxidants vitamin C, vitamin E and selenium, another group includes the carotenoids, such as beta-carotene, lycopene, lutein and astaxanthin. Another subgroup comprises the flavonoids found in most fruits. All these antioxidants are molecules that plants use to protect themselves against environmental factors as solar radiation, heat, toxic chemicals, molds, etc. But these antioxidants also protect animal life. Antioxidants protect all life on earth - plants, animals and humans - against the damaging effects of oxygen radicals, which are always formed in an oxygenated environment. Over eons of time all living forms evolved together and thus depend on each other for survival. So it happened that fruit and vegetables, especially rich in antioxidants, are needed for humans and animals to preserve their health.
-----------
Thus, the best advice for maintaining health continues to be: eat an excellent diet (whole grains, dark green leafy vegetables, fruits, and nuts, with minimal amounts of meat), avoid processed foods that lack essential nutrients, and supplement with adequate doses of essential vitamins, nutrients and antioxidants such as vitamins C and E, zinc, carotenoids and flavonoids.
-----------------end excerpt
Posted by Christ_empowered on August 2, 2015, at 18:33:13
In reply to Antioxidants: The Real Story, posted by stan_the_man70 on August 2, 2015, at 10:22:15
yup. I think antioxidants are important for everyone, but "crazy" people need them even more. Stress, maybe genetics, meds, more stress...you get the picture.
I take 12 grams C, 1000 IU natural form E w/mixed tocopherols, 12mgs Astaxanthin and 2-3 grams green tea extract per day, in addition to more standard orthomolecular stuff (3 grams B3, b-100 2x daily, etc.).
I feel so much better. I don't freak out, I don't get the rashes and stuff I used to get from the stress, my meds don't cause much in the way of side effects...
Good times.
Thanks for the postings.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.