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Niacin and Schizophrenia: History and Opportunity

Posted by stan_the_man70 on August 2, 2015, at 9:58:45

In reply to anyone heard of riordan clinic?, posted by stan_the_man70 on July 30, 2015, at 12:31:52

------------quote reference
http://www.orthomolecular.org/resources/omns/v10n18.shtml
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FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, October 27, 2014
Niacin and Schizophrenia: History and Opportunity
by Nick Fortino, PhD Candidate

------------------excerpt
Evidence for the Niacin Treatment of Schizophrenia

Vitamin B3 as a treatment for schizophrenia is typically overlooked, which is disconcerting considering that historical evidence suggests it effectively reduces symptoms of schizophrenia, and has the added advantage, in contrast to pharmaceuticals, of mild to no adverse effects (22-35). After successful preliminary trials treating schizophrenia patients with niacin, pilot trials of larger samples commenced in 1952-reported in 1957 by Hoffer, Osmond, Callbeck, and Kahan. Dr. Abram Hoffer began an experiment involving 30 patients who had been diagnosed with acute schizophrenia. Participants were given a series of physiological and psychological tests to measure baseline status and were subsequently assigned randomly to treatment groups. Nine subjects received a placebo, 10 received nicotinic acid, and 11 received nicotinamide (the latter two are forms of vitamin B3). All participants received treatment for 42 days, were in the same hospital, and received psychotherapy from the same group of clinicians. The two experimental groups were administered three grams of vitamin B3 per day. Each of the three treatment groups improved, but the two vitamin B3 groups improved more than the placebo group as compared to baseline measures. At one year follow up, 33% of patients in the placebo group remained well, and 88% of patients in the B3 groups remained well. These results inspired many subsequent trials, and those that replicated the original method produced similarly positive results.

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