Psycho-Babble Medication Thread 1079954

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Study shows drug combo that treats bipolar dep.

Posted by Phil on June 24, 2015, at 17:33:13

http://newsdaily.com/2015/06/study-shows-drug-combination-can-treat-bipolar-depression/

 

Re: Study shows drug combo that treats bipolar dep.

Posted by Hugh on June 24, 2015, at 17:45:51

In reply to Study shows drug combo that treats bipolar dep., posted by Phil on June 24, 2015, at 17:33:13

Sounds promising, especially since the drugs are already FDA-approved. I found this about the dosages used in the study:

Subjects then received open-label ketamine hydrochloride (0.5 mg/kg administered intravenously over 60 minutes) followed by 8 weeks of d-cycloserine (titrated to 1,000 mg/d from a starting dose of 250 mg over 3 weeks) and pyridoxine, adjunctive to continued FDA-approved treatment and mood stabilizers.

Complete article:

http://www.psychiatrist.com/JCP/article/Pages/2015/v76n06/v76n0609.aspx

 

Re: Study shows drug combo that treats bipolar dep.

Posted by SLS on June 24, 2015, at 18:47:46

In reply to Re: Study shows drug combo that treats bipolar dep., posted by Hugh on June 24, 2015, at 17:45:51

> Sounds promising, especially since the drugs are already FDA-approved. I found this about the dosages used in the study:
>
> Subjects then received open-label ketamine hydrochloride (0.5 mg/kg administered intravenously over 60 minutes) followed by 8 weeks of d-cycloserine (titrated to 1,000 mg/d from a starting dose of 250 mg over 3 weeks) and pyridoxine, adjunctive to continued FDA-approved treatment and mood stabilizers.
>
> Complete article:
>
> http://www.psychiatrist.com/JCP/article/Pages/2015/v76n06/v76n0609.aspx

One can use intranasal administration of ketamine to good effect, obviating the cost and inconvenience of I.V. It can be taken at regular intervals - either every day or every few days. Some people even respond to once-a-week administration. It works for some people, but not for me, unfortunately. I found it very tolerable, though. You can get a prescription and have it filled by a compounding pharmacy pretty cheap. I wish I would have known about D-cycloserine sooner. I might have tried to combine the two drugs. I would first try intranasal ketamine without it, though.

http://ecompoundingpharmacy.com/


- Scott

 

Re: Study shows drug combo that treats bipolar dep.

Posted by linkadge on June 25, 2015, at 19:29:44

In reply to Re: Study shows drug combo that treats bipolar dep., posted by SLS on June 24, 2015, at 18:47:46

From the reading I just did, cycloserine seems to be better for fear extinction than for depression.

Linkadge


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