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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by MuseMemento on May 30, 2015, at 22:28:58
Hi, all. Are higher doses of clomipramine more activating than lower doses due to increase norepinephrine reuptake inhibition? I've just begun my third attempt at reaching a therapeutic level of clomipramine for OCD and MDD but I've been sleeping upwards of 20 hours on 50 mg. Will the fatigue reduce at higher doses? Thanks. I'm also taking 20 mg memantine and 5 mg abilify.
Posted by phidippus on June 11, 2015, at 1:17:30
In reply to Clomipramine Dose Response, posted by MuseMemento on May 30, 2015, at 22:28:58
When I first started Clomipramine at 75 mg, I was a little foggy. By the time I was at 300 mg I was pretty alert.
Eric
Posted by MuseMemento on June 13, 2015, at 17:56:42
In reply to Re: Clomipramine Dose Response » MuseMemento, posted by phidippus on June 11, 2015, at 1:17:30
Thanks, Eric. I've now been on 150 for four days but I'm still sleeping between 16-20 hours a day, which only began when I initiated clomipramine, and the remaining hours I spent on the couch. We decided to give it two more weeks to see if anything positive occurs.
Posted by phidippus on June 14, 2015, at 16:54:44
In reply to Re: Clomipramine Dose Response » phidippus, posted by MuseMemento on June 13, 2015, at 17:56:42
have you considered adding nuvigil or dextroamphetamine?
Eric
Posted by musememento on June 14, 2015, at 17:22:13
In reply to Re: Clomipramine Dose Response » MuseMemento, posted by phidippus on June 14, 2015, at 16:54:44
I've actually been mulling that over the last 24 hours. Not sure if my pdoc would go for it. Would nuvigil detrimentally alter the ratio of parent drug to active metabolite?
Posted by Meltingpot on July 8, 2015, at 9:44:26
In reply to Clomipramine Dose Response, posted by MuseMemento on May 30, 2015, at 22:28:58
Hi,
When I started on 75mg of Clomipramine, I had really bad anxiety (which I always seem to get at lower doses), I wasn't particularly sleepy on that dose. After 5 weeks we upped it to 150mg and the anxiety went away but I did feel incredibly drowsy on it (which was preferable to the anxiety and being depressed). I stayed feeling drowsy on it for the year that I was on it but managed to keep going to work etc.
Having said that I've kind of experimented with 150mg of it fairly recently and didn't feel drowsy.
Denise
This is the end of the thread.
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