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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by brynb on July 18, 2014, at 8:26:13
Hi All-
Hope you're all doing well (or at least getting there)!
I was curious if anyone has heard of BRINTELLIX. My friend is a drug rep for it and I've heard very little about it. How does it work (on what receptors)? What's its efficacy so far, etc.?
I'd love some feedback. Hope you're enjoying the summer.
-b
Posted by Phillipa on July 18, 2014, at 9:45:05
In reply to BRINTELLIX, posted by brynb on July 18, 2014, at 8:26:13
Bryn there have been quite a few people on here on Brintellix. Off hand I don't remember much about it. Since also slow here. Try achieves or even this page and seek out a link on it. Also lost all addresses from my computer when in for repairs. Are you needing or thinking of switching from Lexapro? Phillipa
Posted by brynb on July 19, 2014, at 1:30:22
In reply to Re: BRINTELLIX » brynb, posted by Phillipa on July 18, 2014, at 9:45:05
p-
i don't want to try it, i'm good on my current (same) regimen, i was just curious as a friend of mine is a drug rep for it and i hadn't heard of anyone on it.
how are you?
Posted by phidippus on July 19, 2014, at 12:12:01
In reply to BRINTELLIX, posted by brynb on July 18, 2014, at 8:26:13
Vortioxetine is a so-called "serotonin modulator and stimulator". It has been shown to possess the following pharmacological actions:
Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM
Norepinephrine transporter (NET) blocker Ki = 113 nM
5-HT1A receptor high-efficacy partial agonist/near-full agonist Ki = 15 nM, IA = 80%
5-HT1B receptor partial agonist Ki = 33 nM
5-HT1D receptor antagonist Ki = 54 nM
5-HT3A receptor antagonist Ki = 3.7 nM
5-HT7 receptor antagonist Ki = 19 nMVortioxetine also has affinity for the β1-adrenergic receptor (Ki = 46 nM), though any actions at this site are unlikely to contribute to its therapeutic effects and likely only to contribute to side effects.
I took it for a month. Very strong stuff.
Eric
Posted by Chris O on July 19, 2014, at 12:36:48
In reply to BRINTELLIX, posted by brynb on July 18, 2014, at 8:26:13
brynb:
I don't remember if I have interacted with you, but I've been on Brintellix for, oh, going on 4 months now. I'm taking 30mg a day. It's okay, giving me a maybe 3.5/10 relief for chronic unrelating anxiety and depression. I'm getting ready to try something else, though, as I cannot afford the "discounted" $250/month prescription (a bottle of thirty 20mg pills). (And I have decent health insurance to get this rate.) Anyway, my psychiatrist has been giving me samples of Brintellix the whole time to give the stuff a fair trial. On the positive side, no real side effects to make note of on Brintellix, except for some (not a huge amount) decreased sexual desire and decreased sexual pleasure. I just wish the stuff did more for me on the anti-anxiety/anti-depressant end. Another thing I have noticed is that Brintellix is better for me than Vybriid. I tried Vybriid for about 8 months when it came out two years ago. I know that these Brintellix and Vybriid are supposed to have a similar mechanism of action. Hope my feedback is useful to you in some way.
Chris
Posted by Beckett on July 19, 2014, at 15:09:33
In reply to Re: BRINTELLIX » brynb, posted by Chris O on July 19, 2014, at 12:36:48
Sorry it's not working out well. My doc wanted to prescribe it, but I went for the old workhorse, lexapro. So far it is sitting on the pharmacy shelf.
Btw, fwiw, four days of Fetzima and had grand mal panic attack.
Posted by Chris O on July 20, 2014, at 2:46:15
In reply to Re: BRINTELLIX » Chris O, posted by Beckett on July 19, 2014, at 15:09:33
It's just not strong enough. Plus, it doesn't "open me up" like I need to be. Still a walled in feeling, like I need to apologize to people all the time. On the Fetzmia, that's interesting. My psychiatrist suggested that Fetzmia probably wouldn't work well with my anxious depression, and perhaps your reaction tapped into what he was saying. I took Lexapro in 2004, around the time it came out. I was on it for about a year--40mg a day (I think that was considered a high dose at the time)--but it did nothing for me. I hope it works for you, if you decide to take it.
Chris
Posted by ihatedrugs1 on July 24, 2014, at 10:31:26
In reply to BRINTELLIX, posted by brynb on July 18, 2014, at 8:26:13
> Hi All-
>
> Hope you're all doing well (or at least getting there)!
>
> I was curious if anyone has heard of BRINTELLIX. My friend is a drug rep for it and I've heard very little about it. How does it work (on what receptors)? What's its efficacy so far, etc.?
>
> I'd love some feedback. Hope you're enjoying the summer.
>
> -b
>
>
I've been on B for six weeks along with Abilify and have seen a dip in my mood. I'm now thinking about going back on Lex and abilify; I think I felt better then.Glad you are doing well.
ihatedrugs
Posted by brynb on July 24, 2014, at 11:44:58
In reply to Re: BRINTELLIX, posted by ihatedrugs1 on July 24, 2014, at 10:31:26
Thanks everyone for your input. It doesn't sound very promising. I'm still on Lexapro 20mg, Ativan, Tramadol and Vyvanse (mg varies).
I've noticed I can't take Vyvanse "breaks"; if I do, my mood and energy level dips way too low. But, I'm wondering if it's causing an underlying melancholia that I can't shake, along with a cranky, irritable mood that hits me in the afternoon. I'm fighting it as I love the initial energy and mood elevation it gives me, though I'm not so sure it's worth it.
Thanks again--wishing happiness (or at least some peace) to all of you.
-b
Posted by ihatedrugs1 on July 24, 2014, at 12:09:59
In reply to Re: BRINTELLIX, posted by brynb on July 24, 2014, at 11:44:58
> Thanks everyone for your input. It doesn't sound very promising. I'm still on Lexapro 20mg, Ativan, Tramadol and Vyvanse (mg varies).
>
> I've noticed I can't take Vyvanse "breaks"; if I do, my mood and energy level dips way too low. But, I'm wondering if it's causing an underlying melancholia that I can't shake, along with a cranky, irritable mood that hits me in the afternoon. I'm fighting it as I love the initial energy and mood elevation it gives me, though I'm not so sure it's worth it.
>
> Thanks again--wishing happiness (or at least some peace) to all of you.
>
> -bBrynb,
I also take Vyvanse and the same happens to me.Sometimes I take an additional Adderall in the afternoon to extend the relief it offers. In the beginning with Vyvanse, it would last a while, now I'm lucky if I get 5 hours of relief. The melancholia is part of the comedown. I wonder if anyone knows how to make it less pronounced.
ihatedrugs
Posted by brynb on July 24, 2014, at 12:33:44
In reply to Re: BRINTELLIX, posted by ihatedrugs1 on July 24, 2014, at 12:09:59
> > Thanks everyone for your input. It doesn't sound very promising. I'm still on Lexapro 20mg, Ativan, Tramadol and Vyvanse (mg varies).
> >
> > I've noticed I can't take Vyvanse "breaks"; if I do, my mood and energy level dips way too low. But, I'm wondering if it's causing an underlying melancholia that I can't shake, along with a cranky, irritable mood that hits me in the afternoon. I'm fighting it as I love the initial energy and mood elevation it gives me, though I'm not so sure it's worth it.
> >
> > Thanks again--wishing happiness (or at least some peace) to all of you.
> >
> > -b
>
> Brynb,
>
> I also take Vyvanse and the same happens to me.Sometimes I take an additional Adderall in the afternoon to extend the relief it offers. In the beginning with Vyvanse, it would last a while, now I'm lucky if I get 5 hours of relief. The melancholia is part of the comedown. I wonder if anyone knows how to make it less pronounced.
>
> ihatedrugs
hi ihatedrugs,that makes sense. and i had a feeling that was the culprit. i've lowered my dose to 30mg daily, which, like you said, doesn't really do much anymore, but the higher i go, the more irritable i get. as for the melancholia, i have to decide if it's worth it for me to continue. sadness is one of the more pronounced symptoms of my depression, so naturally i need to avoid anything that makes it worse.
thanks!
Posted by SLS on July 25, 2014, at 11:25:25
In reply to Re: BRINTELLIX, posted by ihatedrugs1 on July 24, 2014, at 12:09:59
> > Thanks everyone for your input. It doesn't sound very promising. I'm still on Lexapro 20mg, Ativan, Tramadol and Vyvanse (mg varies).
> >
> > I've noticed I can't take Vyvanse "breaks"; if I do, my mood and energy level dips way too low. But, I'm wondering if it's causing an underlying melancholia that I can't shake, along with a cranky, irritable mood that hits me in the afternoon. I'm fighting it as I love the initial energy and mood elevation it gives me, though I'm not so sure it's worth it.
> >
> > Thanks again--wishing happiness (or at least some peace) to all of you.
> >
> > -b
>
> Brynb,
>
> I also take Vyvanse and the same happens to me.Sometimes I take an additional Adderall in the afternoon to extend the relief it offers. In the beginning with Vyvanse, it would last a while, now I'm lucky if I get 5 hours of relief. The melancholia is part of the comedown. I wonder if anyone knows how to make it less pronounced.
>
> ihatedrugs
Have you tried Focalin dexmethylphenidate? In my experience, the "let down" is less pronounced.
- Scott
Posted by brynb on July 25, 2014, at 11:58:52
In reply to Re: BRINTELLIX » ihatedrugs1, posted by SLS on July 25, 2014, at 11:25:25
Hi Scott,
Hope you're well! What is Focalin again? My pdoc is funny about what he "allows" as I've had substance abuse issues in the past.
Thanks.
B
Posted by ihatedrugs1 on July 25, 2014, at 12:13:16
In reply to Re: BRINTELLIX » ihatedrugs1, posted by SLS on July 25, 2014, at 11:25:25
> > > Thanks everyone for your input. It doesn't sound very promising. I'm still on Lexapro 20mg, Ativan, Tramadol and Vyvanse (mg varies).
> > >
> > > I've noticed I can't take Vyvanse "breaks"; if I do, my mood and energy level dips way too low. But, I'm wondering if it's causing an underlying melancholia that I can't shake, along with a cranky, irritable mood that hits me in the afternoon. I'm fighting it as I love the initial energy and mood elevation it gives me, though I'm not so sure it's worth it.
> > >
> > > Thanks again--wishing happiness (or at least some peace) to all of you.
> > >
> > > -b
> >
> > Brynb,
> >
> > I also take Vyvanse and the same happens to me.Sometimes I take an additional Adderall in the afternoon to extend the relief it offers. In the beginning with Vyvanse, it would last a while, now I'm lucky if I get 5 hours of relief. The melancholia is part of the comedown. I wonder if anyone knows how to make it less pronounced.
> >
> > ihatedrugs
>
>
> Have you tried Focalin dexmethylphenidate? In my experience, the "let down" is less pronounced.
>
>
> - Scott
>No, haven't tried it. Vyvanse used to be fine but after a couple of years on it, it seems to have lost some of its effectiveness. I will ask my doctor about Focalin.
I hope you are doing well.
ihatedrugs
Posted by Beckett on July 25, 2014, at 14:41:19
In reply to Re: BRINTELLIX, posted by ihatedrugs1 on July 25, 2014, at 12:13:16
FWIW, I have been using Daytrana, a transdermal patch of ritalin. I could not find a way to deal with the ups and downs of oral stimulants including Vyvanse.
Posted by SLS on July 25, 2014, at 18:09:20
In reply to Re: BRINTELLIX » SLS, posted by brynb on July 25, 2014, at 11:58:52
Hi.
> Hope you're well! What is Focalin again? My pdoc is funny about what he "allows" as I've had substance abuse issues in the past.
Focalin (dexmethylphenidate) is a modified version of Ritalin (methylphenidate). It is a purification of the D-isomer molecule. Focalin is supposed to produce a therapeutic effect while reducing unwanted side effects. Ritalin never did much for me except to make me feel uncomfortably irritable. By contrast, Focalin produces a smooth energizing effect that lasts for 5 - 6 hours. Although I can feel when it wears off, I do not experience anything that I would describe as being depression or profound fatigue. I can't attest to the potential for one to become tolerant to Focalin. I have not taken it for more than a few days at a time.
- Scott
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