Posted by phidippus on July 19, 2014, at 12:12:01
In reply to BRINTELLIX, posted by brynb on July 18, 2014, at 8:26:13
Vortioxetine is a so-called "serotonin modulator and stimulator". It has been shown to possess the following pharmacological actions:
Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM
Norepinephrine transporter (NET) blocker Ki = 113 nM
5-HT1A receptor high-efficacy partial agonist/near-full agonist Ki = 15 nM, IA = 80%
5-HT1B receptor partial agonist Ki = 33 nM
5-HT1D receptor antagonist Ki = 54 nM
5-HT3A receptor antagonist Ki = 3.7 nM
5-HT7 receptor antagonist Ki = 19 nMVortioxetine also has affinity for the β1-adrenergic receptor (Ki = 46 nM), though any actions at this site are unlikely to contribute to its therapeutic effects and likely only to contribute to side effects.
I took it for a month. Very strong stuff.
Eric
poster:phidippus
thread:1068465
URL: http://www.dr-bob.org/babble/20140717/msgs/1068541.html