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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 30. This is the beginning of the thread.
Posted by phidippus on February 23, 2014, at 18:18:33
I feel calm.
Eric
Posted by SLS on February 23, 2014, at 18:49:16
In reply to 7 days on Brintellix, posted by phidippus on February 23, 2014, at 18:18:33
> I feel calm.
>
> EricGood start?
If I weren't on Parnate, I would try Brintellix (vortioxetine) next. I am becoming very interested in 5-HT7 receptors and their antagonism. I am currently trying Saphris (asenapine) because it is a 5-HT7 antagonist. However, I am not very happy that Saphris is also a D2, 5-HT1a, and NE alpha-2a receptor antagonist. I will be very happy to see this drug work for you.
Good luck.
- Scott
Posted by LouisianaSportsman on February 23, 2014, at 20:46:19
In reply to Re: 7 days on Brintellix » phidippus, posted by SLS on February 23, 2014, at 18:49:16
Scott, I'm surprised you didn't say anything on my thread.
Posted by SLS on February 23, 2014, at 21:06:28
In reply to Re: 7 days on Brintellix, posted by LouisianaSportsman on February 23, 2014, at 20:46:19
> Scott, I'm surprised you didn't say anything on my thread.
Oh. Sorry. I apologize. Can you direct me to it?
Please note my correction. Levomilnacipran (Fetzima) is not a 5-HT7 receptor antagonist.
Asenapine (Saphris) has been soporific for me. It has me sleeping for most of the day. I am taking only 5 mg/day. I plan to try splitting the tablets and take 2.5 mg b.i.d. So far, I have not experienced a worsening of depression the way I expected. If anything, it might be helping. My friend found Saphris to be energizing after her very first dose. Why can't I get so lucky? I am trying not to get too encouraged at this point.
I hope you find Psycho-Babble to be helpful. Again, I apologize for not posting along your thread. Either I didn't see it or didn't have the energy to respond to it when I first saw it.
- Scott
Posted by Phillipa on February 23, 2014, at 21:20:23
In reply to 7 days on Brintellix, posted by phidippus on February 23, 2014, at 18:18:33
Eric first person I've seen to go on this med. Good luck. Phillipa
Posted by johnLA on February 24, 2014, at 1:31:48
In reply to 7 days on Brintellix, posted by phidippus on February 23, 2014, at 18:18:33
any side-effects yet eric?
and, welcome back!
john
Posted by Lamdage22 on February 24, 2014, at 6:27:17
In reply to Re: 7 days on Brintellix » LouisianaSportsman, posted by SLS on February 23, 2014, at 21:06:28
How is it going with Brintellix?
I am considering this. I am attracted by the lack of sexual SEs and the novel modes of action. Finally there is a new non "me too" drug.
I will ask my pdoc on Wednesday.
Posted by phidippus on February 24, 2014, at 17:00:57
In reply to Re: 7 days on Brintellix, posted by Lamdage22 on February 24, 2014, at 6:27:17
I'm surprised at how good I feel only after a week on Brintellix. Some of its modes of action must work quicker than others.
Eric
Posted by phidippus on February 24, 2014, at 18:03:27
In reply to Re: 7 days on Brintellix » phidippus, posted by johnLA on February 24, 2014, at 1:31:48
no side effects yet!
Eric
Posted by phidippus on February 24, 2014, at 18:21:02
In reply to Re: 7 days on Brintellix » phidippus, posted by SLS on February 23, 2014, at 18:49:16
What cascade of events follows the antagonism of the 5ht7 receptor and what neuropsychiatric effects does it have?
Eric
Posted by SLS on February 25, 2014, at 5:59:21
In reply to Re: 7 days on Brintellix » SLS, posted by phidippus on February 24, 2014, at 18:21:02
Hi Eric.
> What cascade of events follows the antagonism of the 5ht7 receptor and what neuropsychiatric effects does it have?
>
> EricI apologize for the delay.
5-HT7 antagonism (heteroreceptor) > 5-HT release inhibition (5-HT1a mediated) > dopamine efflux (PFC, hippocampus, nucleus accumbens).
You are going to find this WAY cool:
http://www.ncbi.nlm.nih.gov/pubmed/22415605
I REALLY hope Brintellix works. I am hopeful for you.
- Scott
Posted by jono_in_adelaide on February 25, 2014, at 18:53:20
In reply to Re: 7 days on Brintellix » phidippus, posted by SLS on February 25, 2014, at 5:59:21
Scott
would you be willing to try 1mg of risperidone at night in order to hit the 5HT7 receptor (start off with 0.5mg for 2 nights, then go to 1mg)
Posted by SLS on February 25, 2014, at 20:56:00
In reply to Re: 7 days on Brintellix - SLS, posted by jono_in_adelaide on February 25, 2014, at 18:53:20
> Scott
>
> would you be willing to try 1mg of risperidone at night in order to hit the 5HT7 receptor (start off with 0.5mg for 2 nights, then go to 1mg)
I'll ask my doctor about that. Thanks.I did try adding risperidone to Parnate about 13 years ago. However, my regime has changed substantially since then.
- Scott
Posted by phidippus on February 26, 2014, at 17:24:31
In reply to Re: 7 days on Brintellix » phidippus, posted by SLS on February 25, 2014, at 5:59:21
It also does all this:
Serotonin transporter (SERT) blocker (i.e. serotonin reuptake inhibitor (SRI)) Ki (binding affinity) = 1.6 nM, IC50 = 5.4 nM
Norepinephrine transporter (NET) blocker Ki = 113 nM
5-HT1A receptor high-efficacy partial agonist/near-full agonist Ki = 15 nM, IA = 80%
5-HT1B receptor partial agonist Ki = 33 nM
5-HT1D receptor antagonist Ki = 54 nM
5-HT3A receptor antagonist Ki = 3.7 nM
5-HT7 receptor antagonist Ki = 19 nMI'm hitting day 12 on it - 3rd day at the 20 mg dose and I feel nifty. Its like my brain is opening up.
Eric
Posted by tommy12003 on February 26, 2014, at 17:50:16
In reply to Re: 7 days on Brintellix - SLS » jono_in_adelaide, posted by SLS on February 25, 2014, at 20:56:00
any sexual dysfunction?
Posted by Lamdage22 on February 27, 2014, at 11:58:10
In reply to Re: 7 days on Brintellix - SLS, posted by tommy12003 on February 26, 2014, at 17:50:16
Good stuff!
I wish this was on germanys market.
My doctor said that lundbeck was quick with approvals in germany.
And i also ask: Anorgasmia?
Posted by phidippus on February 27, 2014, at 14:34:36
In reply to Re: 7 days on Brintellix - SLS, posted by Lamdage22 on February 27, 2014, at 11:58:10
I came buckets last night!
Eric
Posted by SLS on February 27, 2014, at 15:12:09
In reply to Re: 7 days on Brintellix » SLS, posted by phidippus on February 26, 2014, at 17:24:31
> I'm hitting day 12 on it - 3rd day at the 20 mg dose and I feel nifty. Its like my brain is opening up.
"Nifty" sounds good. Can you expand on this description?
Thanks.
I hope you are able to keep a diary of sorts along this thread.
I am very excited about Brintellix, despite some negative reports (hearsay). I am particularly interested in its ability to block 5-HT7 receptors, although 5-HT1a partial agonism is important to me, too. I would not expect that it would make me feel worse. Unfortunately, I would have to discontinue Parnate in order to take Brintellix. It would take a minimum of 3 weeks before I would be able to start it. Were it not for its SRI property, I could simply add it right now.
What would be really cool is if I could discontinue Abilify if the addition of Brintellix were to work for me. In addition to being a D2/D3 partial agonist, Abilify is a 5-HT7 antagonist and a 5-HT1a partial agonist. So, if the dopaminergic properties of Abilify are not contributing to the improvement it gives me, I might be able to jettison it and lose the 60 pounds it put on me.
- Scott
Posted by phidippus on February 27, 2014, at 16:20:47
In reply to Re: 7 days on Brintellix » phidippus, posted by SLS on February 27, 2014, at 15:12:09
4th day 20 mgs.
I feel nifty.
This means Brintellix's anxiolytic properties are in full force. I'm taking this for OCD and am not too concerned about what its doing for my mood, although I have to say I've been pretty perky.
One interesting thing I notice is that my mind seems more 'open' as I am finding a lot more things to think about and I am enjoying thinking more. Thoughts are less heavy and I don't seem to be wading through a heap of negative ideations.
I've not experienced much in the way of side effects except for some stomach discontent.
Eric
ps. this drug starts working remarkably fast.
Posted by Phillipa on February 27, 2014, at 20:28:58
In reply to Re: 7 days on Brintellix » SLS, posted by phidippus on February 27, 2014, at 16:20:47
Eric since we both have some form of OCD please keep me updated. Phillipa
Posted by Lamdage22 on March 2, 2014, at 10:35:10
In reply to Re: 7 days on Brintellix » phidippus, posted by Phillipa on February 27, 2014, at 20:28:58
Idiscontinued Effexor due to anorgasmia.. when i reduced from 150 to 75, i got suicidal thoughts the first day. Now i reduced to 0 for the first day and i am suicidal again.
This Brintellix is not yet on the german market. I will try to push my doc to prescribe anyway.
Alternative would be Nortryptiline... isnt that purely noradrenergic? How is this supposed to help-
Help!
Posted by phidippus on March 2, 2014, at 18:20:11
In reply to Re: 7 days on Brintellix, posted by Lamdage22 on March 2, 2014, at 10:35:10
What antidepressants have you tried?
Eric
Posted by SLS on March 2, 2014, at 20:16:13
In reply to Re: 7 days on Brintellix, posted by Lamdage22 on March 2, 2014, at 10:35:10
Sorry for the little aside...
What are you taking metformin for, and what are the results?
Thanks.
- Scott
Posted by Lamdage22 on March 3, 2014, at 0:59:14
In reply to Re: 7 days on Brintellix » Lamdage22, posted by SLS on March 2, 2014, at 20:16:13
I tried Valdoxan, Remeron, Sertraline, Paroxetine, Cymbalta, Effexor.
My doctor suggested Nortryptiline, i want to try Brintellix.
Posted by doxogenic boy on March 7, 2014, at 16:27:59
In reply to Re: 7 days on Brintellix, posted by Lamdage22 on March 3, 2014, at 0:59:14
> I tried Valdoxan, Remeron, Sertraline, Paroxetine, Cymbalta, Effexor.
> My doctor suggested Nortryptiline, i want to try Brintellix.Have you tried Tianeurax? It is generic tianeptine manufactured in Germany.
Here is some information from the manufacturer:
http://www.neuraxpharm.de/html-de/erkrankungen-praeparate-detailansicht.php?name=Tianeuraxhttp://www.neuraxpharm.de/download-pil.php?pfad=GI_Tianeurax_12_5_mg_-_368_2.pdf
I have used it for 172 days, and for me it has been just as good as Stablon, which I used before.
There is a case showing that tianeptine can work together with an SSRI.I have quoted from it in this post:
http://www.dr-bob.org/babble/20090826/msgs/914964.htmlI have used high-dose tianeptine in combination with among others escitalopram 40 mg since October 2009 (see my signature), and it still works very well - no tolerance build-up.
- doxogenic
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