Psycho-Babble Medication Thread 1046194

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serotinergic drug

Posted by joef on July 1, 2013, at 21:22:03

would an ssri that is "highly" serotinergic cause --sedation or restlessness

 

Re: serotinergic drug » joef

Posted by SLS on July 1, 2013, at 21:51:16

In reply to serotinergic drug, posted by joef on July 1, 2013, at 21:22:03

> would an ssri that is "highly" serotinergic cause --sedation or restlessness

I am reluctant to offer an answer to your question because there is great interindividual variability in the way people react to SSRIs. These drugs each do more than simply inhibit the reuptake of serotonin. These additional properties contribute to the different behaviors these drugs demonstrate clinically.

The "strongest" SSRI is paroxetine (Paxil). This is defined as a function of the binding affinity of the drug to the serotonin transporter.

The most "selective" SSRI is escitalopram (Lexapro). This is a misnomer, though. Selectivity has been historically defined as reuptake inhibition relative to other monoamine neurotransmitters. It does not take into account all of the properties of these drugs that have since been discovered.

* Fluvoxamine (Luvox) tends to be sedating.
* Fluoxetine (Prozac) tends to be energizing.
* Paroxetine (Paxil) tends to be anxiolytic, although not always sedating.


- Scott

 

Re: serotinergic drug

Posted by joef on July 1, 2013, at 22:09:08

In reply to Re: serotinergic drug » joef, posted by SLS on July 1, 2013, at 21:51:16

from your knowledge where would viibryd fall into this category...saidto be highly serotinergic

 

Re: serotinergic drug » SLS

Posted by Phillipa on July 1, 2013, at 23:17:44

In reply to Re: serotinergic drug » joef, posted by SLS on July 1, 2013, at 21:51:16

Scott exactly the reactions I had to these three SSRI's. Prozac caused anxiety I didn' have. Phillipa


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