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Dr. Bob is Robert Hsiung, MD,
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Posted by Lamdage22 on October 7, 2011, at 20:24:15
In reply to Lamdage22! » Lamdage22, posted by shot_away on October 7, 2011, at 17:35:10
> Lamdage! Any chance you can turn on your babblemail briefly for a quick private exchange of words?
Sure.. Consider it done. 90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
Posted by shot_away on October 8, 2011, at 7:46:56
In reply to Re: Lamdage22!, posted by Lamdage22 on October 7, 2011, at 20:24:15
> Sure.. Consider it done. 90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
Yes but wait till you get to 80mg+ and feel the postural hypotention! Its what im battling with now at 90mg after over 3 years on it! And thats before i added abilify too which has the same effect on me. Ah well...
Posted by Chairman_MAO on October 9, 2011, at 8:30:51
In reply to Re: Lamdage22! » Lamdage22, posted by shot_away on October 8, 2011, at 7:46:56
Re: postural hypotension. There are treatments for it, as you are probably aware. Have you tried any of them?
Posted by shot_away on October 9, 2011, at 10:42:03
In reply to Re: Lamdage22! » shot_away, posted by Chairman_MAO on October 9, 2011, at 8:30:51
> Re: postural hypotension. There are treatments for it, as you are probably aware. Have you tried any of them?
Well actuallly, no I haven't. Not sure what my doc would think but please, i'd like to here the options!
Oh, I did do a trial with table salt (sodium) and it did raise my BP but it was too high whilst sat or laying down so I stopped. BP was perfect whilst standing tho, and getting up was better.
Posted by Chairman_MAO on October 9, 2011, at 10:49:19
In reply to Re: Lamdage22! » Chairman_MAO, posted by shot_away on October 9, 2011, at 10:42:03
This list seems pretty good: http://www.dizziness-and-balance.com/disorders/medical/orthostatic.html
Posted by shot_away on October 9, 2011, at 10:50:08
In reply to Re: Lamdage22!, posted by Lamdage22 on October 7, 2011, at 20:24:15
>90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
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>
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>Where did you hear this? I'm interested. Got any links?? What dosage strategy are you planning on urself?
Posted by shot_away on October 9, 2011, at 10:54:02
In reply to Re: Lamdage22! » shot_away, posted by Chairman_MAO on October 9, 2011, at 10:49:19
Posted by Lamdage22 on October 10, 2011, at 5:12:29
In reply to Re: Lamdage22! » Lamdage22, posted by shot_away on October 9, 2011, at 10:50:08
> >90mgs of marplan is not very much, i hear the max recommendet dosage is pussy and undsrestimated.
> >
> >
> >
> >
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> Where did you hear this? I'm interested. Got any links?? What dosage strategy are you planning on urself?Oh i don't remember.. i just scan through very much information so i have an inkling of whats going on with what else is out there.
Im not planning the Marplan yet, got other stuff to take care of.
I think to have heard 120mgs but don't count on it, this is something i believe to have heard somewhere i don't remember.You can just google marplan with words like high dosage, 110mg etc etc.
It may be wise to label my "slight inklings" as such to prevent people from doing things based solely on my posts. Im sure if you search you will find something though. It might very well have been on anxiety support.
Posted by jch on October 14, 2011, at 13:50:10
In reply to Re: Is anyone currently taking Marplan?, posted by jch on September 19, 2011, at 19:05:53
1st post Sept 11, looking for effects of old Marplan.
Might have found an answer. I have been taking Aplenzin and Nardil. First week: 172mgs of Aplenzin w/ 45 mgs Nardil, second week 354mgs Aplenzin w/45mgs Nardil.
I feel so much better, leaden legs gone; energy and motivation rising daily. I t reminds me of my experience with Marplan in the 80's.
Side effects so far: Higher pitch to my Tinnutus (I have had it for 30yrs), indigestion if I take it on an empty stomach and possibly slight constipation (this may be cause I've not been eating my daily Fiber One). None a major problem.
I have been taking Nardil for at least 12 yrs, with various low doses of stimulants. I can't take higher dose of Nardil because I keep fainting, sometimes unexpectedly midday. For years everything was A ok.
A few years ago, things started to go downhill. I don't know if it was due to Nardil poop out or the change in formula. Eventually I had no energy/motivation and my legs felt weak, heavy and achy; but I was perfectly happy as long as I could lay in bed and watch TV. Tried taking no Nardil ( to see if it was doing anything)and that was a mistake. Spent days sobbing in bed, went back on Nardil.
I have tried every MAOI (and maybe 15 other ads) and Nardil best works the best for me other than the old Marplan.
After doing research online, I suggested to my doc the combo of Nardil w/ Wellbutrin, which I had handled well in the past, til it pooped out. I took a copy of a report from 2002 saying it was not dangerous.(will post link)
He suggested I try Aplenzin instead,I really don't remember why.
My only original problem was atypical depression, although I have developed a slight case of agoraphobia recently. I have been seeking successful treatment for 28 yrs. So far this combination and the old Marplan have been the only successes. Mind you, I have only been taking this combination for 2 weeks.As for sleep, I never remembered dreaming before I started taking Nardil; I have had vivid dreams since. I think dreaming happens during REM, guess there's no disturbance. I have, on occasion, not been able to close my eyes and turn off my thoughts, up for 24-36 hrs. This is solved by staying off the internet after 8 pm. Easy fix.
It seems that many people have had problems with weight gain on Nardil. Initially I lost weight which could be explained situationally, my mother died and I opened a new business involving a lot of physical labor. After a couple of years I gained weight, about 20 lbs over ideal. I blamed it on menopause and less exercise. Closed the business and went to bed (2008)went back down to my ideal. I don't know why, less interested in eating and could'nt muster the energy to get to the store. f.y.i. I eat to live not live to eat. Too early to tell what new combo will do.
Will report if anything unexpected happens.
Posted by shot_away on October 14, 2011, at 17:16:46
In reply to Re: Is anyone currently taking Marplan?, posted by jch on October 14, 2011, at 13:50:10
I've been on Nardil + Zyban and Marplan + Zyban. Both worked but both pooped out on me. Any ideas for poop-out?
Posted by shot_away on October 14, 2011, at 17:20:41
In reply to Re: Is anyone currently taking Marplan? » jch, posted by shot_away on October 14, 2011, at 17:16:46
Im thinking of asking for atomoxetine to go with Marplan. What you think? (anyone) I allways have low energy.
Posted by jch on October 14, 2011, at 19:05:05
In reply to Re: Is anyone currently taking Marplan? » jch, posted by shot_away on October 14, 2011, at 17:16:46
I have only just started w/ this combination. I know I'm happy so far' but 2 weeks doesn't even give the full effect of the meds. I am hoping that there's no poop out, or at least not for years. Will continue to report any and all changes.
Posted by Chairman_MAO on October 14, 2011, at 22:37:00
In reply to Re: Is anyone currently taking Marplan? » jch, posted by shot_away on October 14, 2011, at 17:16:46
Yeah. Forget about the bupropion and add memantine, d-amphetamine, or both. Perhaps a TCA (despiramine) or another NE uptake inhibitor? There are many other options.
I don't want to start any flame wars, but frankly bupropion is a joke. It's a very weak psychostimulant with active metabolites. It makes you feel more dysphoric instead of more euphoric in high doses--otherwise it would be a controlled substance. Diethylpropion (Tenuate) is a schedule IV controlled substance.
It is good for helping smokers quit, though.
Posted by jch on October 15, 2011, at 10:20:11
In reply to Re: Is anyone currently taking Marplan? » shot_away, posted by Chairman_MAO on October 14, 2011, at 22:37:00
Don't know about Memantine but I have taken several d-amphetamines and although they worked to alleviate nardil lack of energy for 9 years; for the last 3 they have been totally ineffective. Three years ago I not only had no energy, I didn't want to do anything. Nardil was still having some effect as I was not depressed, I was perfectly happy,as long as I could stay in bed and watch TV.
Two week ago I added Aplenzin and for the last 3 days I have been up, bathed, dressed and busy.
This is something that was sometimes impossible for me in the past three years. I have completely blown off appointments or arrived late. Showed up, next door, for Christmas dinner 1 1/2 hrs late, 2 yrs ago;last year I went down the street, again 11/2-2 hrs late. Fortunately, I have understanding friends.
I understand, from some of the messages, that this combination might poop out. I really hope not, because it is the most effective since the mid 90's when I took the old Marplan.and I have taken 15 or so different anti depressants plus various combinations there of.
Posted by Chairman_MAO on October 15, 2011, at 15:12:12
In reply to Re: Is anyone currently taking Marplan?, posted by jch on October 15, 2011, at 10:20:11
I hope it continues to work in the long-term for you.
Posted by Jul on March 9, 2013, at 22:13:14
In reply to Re: Is anyone currently taking Marplan?, posted by jch on September 19, 2011, at 19:05:53
After about a year trying MANY dif antidepressants in about 1985 I had a MHPG 24 Hr Urine Test done and my Psych said it indicated severe resistant depression...VERY low Norepinephrine level!
So he prescribed Marplan (MAO Inhibitor) which acts on ALL THREE(3)Neurotransmitters.
He only resorted to this MAO when nothing else worked.One morning about 6 weeks later, and a few increases in dose, I woke up with the black cloud over me COMPLETELY GONE! and NOTHING in my life had changed! It was the MOST MIRACULOUS change in my life. I no longer felt depressed at all! Dr Frank Bolea of Miami FL saved my life and he REALLY cared about me. All these years later I still think of him and what he did for me!
Jul
Posted by tecknohed on May 28, 2013, at 17:13:52
In reply to Re: Is anyone currently taking Marplan?, posted by Jul on March 9, 2013, at 22:13:14
Hi. I have just found relief from the following each day: 90mg isocarboxazid, 4mg clonazepam, 300mg bupropion, 50mg quetiapine and the last added was Amitryptyline 100mg. And I think its the amitryptyline thats finally kicked in (after several months). Social anxiety is almost gone, I even talk to strangers, when appropriate lol.
Only felt this good once before, which was when I took just phenelzine (Nardil).
I dont consider myself med resistant as most primary docs prescribe totally sh*t meds that wont do anything for my symptoms. Only the psychs use 'big guns' which is a very misguided term. Many are simply old meds, and docs are still frightened to take responsibility of giving someone an MAOI and even many TCAs. it stinks not to allow a sufferer the choice to try these meds. Saves many years of pointless med trials.teck
Posted by tecknohed on May 28, 2013, at 17:52:44
In reply to Marplan winning combo!, posted by tecknohed on May 28, 2013, at 17:13:52
> Hi. I have just found relief from the following each day: 90mg isocarboxazid, 4mg clonazepam, 300mg bupropion, 50mg quetiapine and the last added was Amitryptyline 100mg. And I think its the amitryptyline thats finally kicked in (after several months). Social anxiety is almost gone, I even talk to strangers, when appropriate lol.
> Only felt this good once before, which was when I took just phenelzine (Nardil).
> I dont consider myself med resistant as most primary docs prescribe totally sh*t meds that wont do anything for my symptoms. Only the psychs use 'big guns' which is a very misguided term. Many are simply old meds, and docs are still frightened to take responsibility of giving someone an MAOI and even many TCAs. it stinks not to allow a sufferer the choice to try these meds. Saves many years of pointless med trials.
>
> teck
>Forgot to mention that for the past month I've also been taking Inositol, 650mg 3 x daily. Hard to pick out the effect from all the other meds I take, but I have been feeling somewhat calmer, often allowing me to leave a morning Klonopin pill out a few times a week. And seeing as I'm doing well I'm keeping the inositol.
Posted by Tomatheus on May 28, 2013, at 18:38:02
In reply to Marplan winning combo!, posted by tecknohed on May 28, 2013, at 17:13:52
Tecknohed,
It's great to hear that you're doing as well on your current combo as you were doing when you were taking Nardil. This sounds like another success story. I hope that you'll continue to benefit from your combo for some time.
T.
Posted by SLS on May 28, 2013, at 19:36:08
In reply to Marplan winning combo!, posted by tecknohed on May 28, 2013, at 17:13:52
> I have just found relief from the following each day: 90mg isocarboxazid, 4mg clonazepam, 300mg bupropion, 50mg quetiapine and the last added was Amitryptyline 100mg
That's a very interesting combination. I am surprised that your doctor consented to treat you with it.
I am particularly interested in the addition of amitriptyline and bupropion. How do you know that the bupropion is helping? What has occurred with the addition of amitriptyline that produced such a great antidepressant effect?
Thanks.
I hope your response to treatment is long-lasting.
- Scott
Posted by tecknohed on May 28, 2013, at 20:15:36
In reply to Re: Marplan winning combo! » tecknohed, posted by SLS on May 28, 2013, at 19:36:08
> > I have just found relief from the following each day: 90mg isocarboxazid, 4mg clonazepam, 300mg bupropion, 50mg quetiapine and the last added was Amitryptyline 100mg
>
> That's a very interesting combination. I am surprised that your doctor consented to treat you with it.Well, my pdoc at the time (Professor David Nutt), who ran the outpatient psych clinic became my pdoc when the rest of his team were somewhat uncomfortable with my suggestions and med responses, They put me with the big man. He's great. Lovely personality. And essentially he knew I was only there for meds & med-talk. If I wanted councelling I'll go to a councello/therapist. I like things kept seperate. It was when I reminded him that studies with NRIs show that they infact protect from hypertensive crises, as NRIs have a protecting effect against hypertensive crises. One study was with tranylcypromine + reboxetine. Mice or Rat study.
>
> I am particularly interested in the addition of amitriptyline and bupropion. How do you know that the bupropion is helping?The bupropion Gets me outa bed in the morning, giving great steady energy levels. And I can 'feel' its dopaminergic effects. And with the low dose quetiapine compliments the DA effects of bupropion. Thats how it feels.
And I stopped drinking totally about a month before the amyltryptamine kicked in.> What has occurred with the addition of amitriptyline that produced such a great antidepressant effect?
Hard question. All I can think of is that because of the length I've been depressed and the severety this time round, once started amitryptamine just kicked in after a very delayed response. I've knew an old friends sister who was on Prozac about 3 months before it kicked in.
> Thanks.
>
> I hope your response to treatment is long-lasting.
>
>
> - ScottThankyou!
Posted by stargazer2 on May 29, 2013, at 10:33:49
In reply to Re: Marplan winning combo! » SLS, posted by tecknohed on May 28, 2013, at 20:15:36
Congrats Techno on that combo,
I am still on Marplan 40 mg and my doc added a small dose of Abilify (2mg) and Lithium(600mg) in the last 2 years. I have felt better but for now I'm functional although still feel memory impaired after having 12 or so (can't remember) treatments of ECT in early 2011. I'm not convinced the ECT was helpful but I was on my way out so there weren't alot of choices and I was unable to make a logical decision. They stopped the ECT as I had so many cognitive side effects. I remember nothing about having the treatments but the doc was a nut case and never followed me after the last treatment to see what the benefits/negtive effects were. That to me is outrageous that no one cared that my memory was probably affected and what might be helpful for me to try. HAs anyone experienced this and what has helped you? I though perhaps a med like aricept might be indicated but my psychiatrist isn't convinced. Would a neuropsych test makes sense so far after ECT. Why don;'t they do this test befor ECT and then several times post ECT.
Psychiatry never ceases to disappoint me.
Posted by tecknohed on May 29, 2013, at 18:56:22
In reply to Re: Marplan winning combo!, posted by stargazer2 on May 29, 2013, at 10:33:49
Yes, get a neuro-psychopharmacologist or psychopharmacologist (maybe they are one and the same?). No bull, strait to the point. These experts love nothing more than a hard-case! It's a challenge for them. Willing to use every possible means to give you relief. If you can afford one that is. Here in the UK community Psychiatrists know diddly sh*t about meds, scared of MAOIs & benzos, and often messing with something that dont need messing with, like dosages which are actually getting you better!
And with a psychopharm its med talk only.
Like I allways say, If I want to talk about my psychological issues I'll go to a therapist. If I need med help I see psych doc. I guess its a preference, but I cannot imagine a psychotherapist prescribing me meds.
Lastly, not sure if they still do it, but have you ever had insulin therapy for your depression?
Posted by ed_uk2010 on May 30, 2013, at 17:54:32
In reply to Re: Marplan winning combo! » stargazer2, posted by tecknohed on May 29, 2013, at 18:56:22
Hey, great that you're doing so much better!
>Lastly, not sure if they still do it, but have you ever had insulin therapy for your depression?
Not been performed for many many years. Insulin 'therapy' used a toxic dose of insulin to induce severe hypoglycaemia. This resulted in heavy sweating, coma and convulsions. Some were given ECT whilst unconscious. Patients were then rescued with a dose of IV glucose. Occasionally, patients died or suffered permanent brain damage. Suffice to say the use of insulin in psychiatry was misguided.
Posted by tecknohed on May 30, 2013, at 18:14:57
In reply to Re: Marplan winning combo! » tecknohed, posted by ed_uk2010 on May 30, 2013, at 17:54:32
Well I'm glad they don't do that anymore!
This is the end of the thread.
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