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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by enndub on October 30, 2012, at 11:21:24
So as I am still not getting acceptable results on 75 mg of Nardil alone, I am looking into augmentation/new combinations to try.
I am wondering if anticholinergic side effects go away with time as then I might be able to try some of the TCAs. The most intolerable sides for me are akathisia and auditory hallucinations when tired or falling asleep.
Will these go away if I stick it out on a TCA for a few months? Also, are the auditory hallucinations (just when falling asleep on an anticholinergic med) at all indicative of a psychotic disorder? I want to be prepared with some information if my doc wants to put me on an atypical, as those are a last-resort as far as I am concerned.
Thanks,
Nick
Posted by Hugh on October 30, 2012, at 14:51:55
In reply to Do anticholinergic side-effects go away with time?, posted by enndub on October 30, 2012, at 11:21:24
My worst side effect with a TCA (clomipramine) was constipation. This eventually went away, but not before it gave me hemorrhoids. I wish I'd taken magnesium or some other stool softener, or not taken the clomipramine at all.
Posted by Phillipa on October 30, 2012, at 17:28:47
In reply to Re: Do anticholinergic side-effects go away with time?, posted by Hugh on October 30, 2012, at 14:51:55
Aren't they also huge weight gainers? Phillipa
Posted by enndub on October 31, 2012, at 14:12:54
In reply to Do anticholinergic side-effects go away with time?, posted by enndub on October 30, 2012, at 11:21:24
Thanks guys, if the side-effects do go away with time I might try to stick it out on a TCA after I exhaust all the non-anticholinergic options, even though it will be hell because of the akathisia. Even the crazy Nardil tremor and myoclonic jerks are a walk in the park compared to akathisia. I can pretty much tolerate any other side effect if it means possible relief from depression.
My Nardil is actually working today, though I doubt it will last.
Nick
Posted by Hugh on October 31, 2012, at 15:15:53
In reply to Re: Do anticholinergic side-effects go away with time? » Hugh, posted by Phillipa on October 30, 2012, at 17:28:47
> Aren't they also huge weight gainers? Phillipa
I've heard that they can be. That didn't happen to me, but I didn't take it that long. Remeron is what caused me to gain weight. I was hungry the whole time I was on it.
Posted by jono_in_adelaide on October 31, 2012, at 18:19:29
In reply to Do anticholinergic side-effects go away with time?, posted by enndub on October 30, 2012, at 11:21:24
Desipramine and nortriptyline are both pretty well tolorated so far as anticholinergic effects go, try one of these first
Posted by phidippus on October 31, 2012, at 22:51:41
In reply to Do anticholinergic side-effects go away with time?, posted by enndub on October 30, 2012, at 11:21:24
>Will these go away if I stick it out on a TCA for a few months?
some, maybe not all will go away-I was on Clomipramine for a few months and found its side effects went away after about 2 months.
>Also, are the auditory hallucinations (just when falling asleep on an anticholinergic med) at all indicative of a psychotic disorder?
wow, auditory hallucinations are a rare side effect of any medication. What exactly are you on? Can you describe these hallucinations?
Eric
Posted by papillon2 on November 2, 2012, at 1:38:50
In reply to Re: Do anticholinergic side-effects go away with time? » enndub, posted by phidippus on October 31, 2012, at 22:51:41
I have taken Nortriptyline. For me (your mileage may vary) some of the anti-chlorinergic side effects went away, others lessened, others stayed the same or worsened over time.
Went away:
- Flu-like symptoms
- Orthostatic hypotensionLessened:
- Tachycardia
- Chest pain
- Palpitations
NB: these were thanks in part to co-commitant use of fish oil and baby aspirin. All would worsen to previous levels if I missed a couple of doses.Stayed the same and/or worsened
- Constipation
- Gas and gas pain
- Bloating
- Intolerance to various foods
NB: Movicol and simethicone has helped partly with the first three but they are still a major problem. I've had to reduce my dose and have a referral to see a gastroenterologist.I found it took about a month for my body to get used to each dose increase and stabilize in terms of side effects.
Posted by enndub on November 2, 2012, at 10:21:03
In reply to Re: Do anticholinergic side-effects go away with time? » enndub, posted by phidippus on October 31, 2012, at 22:51:41
> wow, auditory hallucinations are a rare side effect of any medication. What exactly are you on? Can you describe these hallucinations?
Currently I am just on Nardil 75 mg, but even AD-free I experience the auditory hallucinations on pretty much any anticholinergic like Seroquel, Benadryl, Unisom, and Flexeril. The hallucinations are mainly voices, but also other sounds like cars starting or dishes breaking. For example, I will be walking down the street and hear someone whisper "Is that Nick <Last Name>?" only to look around and nobody is around. Or I will be lying in bed and hear different voices, like a black man with a deep voice or trio of girls who all talk at the same time so I can't understand what any of them are saying.
If you search google for "auditory hallucinations benadryl" you get a bunch of posts from recreational drug users who have similar auditory hallucinations plus a bunch of other effects on insanely high doses. Seems like I am super sensitive to the auditory hallucination side effect and can experience it at therapeutic dosages.
Nick
This is the end of the thread.
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