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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by jono_in_adelaide on October 19, 2012, at 18:09:04
Antiquity - Alcohol, opium
1850's - bromides
late 1800's - chloral and various other sedatives
1900 - Barbiturates
1940 - Amphetamine
1950 - Dexamyl/Drinamyl
1955 - Miltown/Equanil, Thorazine/Largactil
1960 - Librium, Nardil, Tofranil
1980 - Buspar
1990 - SSRI's, SNRI's, Remeron
So - whats next?
From my point of view, hopefully an anxiolytic equal to the benzodiazepines that doesnt produce tolorance or dependence
(feel free to add any that I have missed!)
Posted by phillipa on October 19, 2012, at 18:22:15
In reply to Timeline of psychopharmacology, posted by jono_in_adelaide on October 19, 2012, at 18:09:04
Valium think 60's and xanax probably 80's? How bout the SNRI's like effexor, cymbalta. Then those that are different Like remeron, wellbutrin, Oh the mood stabalizers also. How bout atypical antipsychotics some docs use them also for anxiety. Phillipa
Posted by Phil on October 19, 2012, at 18:45:32
In reply to Re: Timeline of psychopharmacology » jono_in_adelaide, posted by phillipa on October 19, 2012, at 18:22:15
I'd like to return to alcohol/opium, skip the alcohol. Better yet, bacon. When I'm eating bacon, the world blends to green and blue, soft as a marshmallow, with Kenny G background music. OK, so the music sucks...nothing is perfect.
Aren't they working with ketamine for depression or whatever? If you OD you go to a nightclub and dance. Strange world. I'd settle for another Seroquel without the metabolic disasters. I was rushed to Childrens Hospital in Houston when I was 3 after banging my head on concrete in a tricycle crash. Too late to worry about brain damage now. In other words, I haven't got a clue. I just know that it won't be a magic bullet.
Posted by jono_in_adelaide on October 19, 2012, at 18:46:54
In reply to Re: Timeline of psychopharmacology » jono_in_adelaide, posted by phillipa on October 19, 2012, at 18:22:15
I forgot about those - especialy the atypicals, they were a huge advance over Thorazine for people with psychosis.
I know OCD is one illness where they desperatly need newer, better drugs..... very few OCD patients ever get full remision.
When my mother first started work as a pharmacist in the mid 60's most doctors were scared of antidepressants like Nardil or Tofranil, and still used amphetamines or Dexamyl - big contrast to today, where antidepressants are handed out more often than aspirin, and where meth is public enemy # 1
Posted by jono_in_adelaide on October 19, 2012, at 19:05:48
In reply to Re: Timeline of psychopharmacology, posted by Phil on October 19, 2012, at 18:45:32
I dont know - most scientitts thought there would never be a magic bullet for bacterial infections until a German dye company accidentaly discovered sulphanilamide - you never know whats around the corner.
But I agree, its unlikely.
Ketamine is nasty stuff, lots of side effects, but i guess if you're at the end of the road, anything is worth a shot.
I read they still do brain surgery for the ultra resistant, severe anxiety disorders, where they ablate a tiny but of brain tissue that seems to be the center of it all.
What I'd give to have that surgery - no more anxiety, and no more bloody pills
Posted by Phil on October 19, 2012, at 20:12:52
In reply to Re: Timeline of psychopharmacology, posted by jono_in_adelaide on October 19, 2012, at 19:05:48
I've been watching video's by Dr Kaku? Talks about the future. A computer on a contact lens that can even recognize people when you can't. One hundred years from now? Nope, they are already working on it.
Tiny computers in your body finding and correcting faulty DNA. They have already reproduced a bladder and it is at work now in someones body. Next, liver and kidneys.The future is the most fascinating thing to me. Oh, to return. So, they will cure these illnesses but others will surface. Who would have imagined AIDS?
Very interesting about the brain surgery. Sign me up. I wonder what a brain without mental illness would feel like?
Posted by jono_in_adelaide on October 19, 2012, at 21:56:52
In reply to Re: Timeline of psychopharmacology, posted by Phil on October 19, 2012, at 20:12:52
http://biopsychiatry.com/psychosurgery.htm
Stereotactic subcaudate tractotomy (SST) is the only type of psychosurgery performed at the Geoffrey Knight Unit, London, where nearly 1300 operations have been done since 1961. Statistically reliable data are not available to prove the effectiveness of SST. A detailed statement about contemporary psychosurgery is given. METHOD. Relevant publications from the Unit and via Medline are discussed. The outcome figures are reviewed. The outcome is assessed at the Unit in global and clinical terms, associated with results of self-completed questionnaires. RESULTS. SST allows 40-60% of patients to live normal or near-normal lives, perhaps with continuation of medication. A reduction in suicide rate to 1% post-operatively, from 15% in cases of uncontrolled affective disorders is seen. CONCLUSION. As a treatment of last resort, no controlled trial against a comparable treatment is possible. It appears reasonable to offer SST to patients with suicidal and deluded depression or with frequently swinging moods, not responding to other treatments.
From the British Medical Journal, 1994
Posted by poser938 on October 19, 2012, at 22:19:19
In reply to Re: Timeline of psycho (psychosurgery), posted by jono_in_adelaide on October 19, 2012, at 21:56:52
I thought the only brain surgery they were doing these days was deep brain stimulation. That sounds like a better alternative than removing part of the brain because it is reversable.
http://biopsychiatry.com/psychosurgery.htm
>
> Stereotactic subcaudate tractotomy (SST) is the only type of psychosurgery performed at the Geoffrey Knight Unit, London, where nearly 1300 operations have been done since 1961. Statistically reliable data are not available to prove the effectiveness of SST. A detailed statement about contemporary psychosurgery is given. METHOD. Relevant publications from the Unit and via Medline are discussed. The outcome figures are reviewed. The outcome is assessed at the Unit in global and clinical terms, associated with results of self-completed questionnaires. RESULTS. SST allows 40-60% of patients to live normal or near-normal lives, perhaps with continuation of medication. A reduction in suicide rate to 1% post-operatively, from 15% in cases of uncontrolled affective disorders is seen. CONCLUSION. As a treatment of last resort, no controlled trial against a comparable treatment is possible. It appears reasonable to offer SST to patients with suicidal and deluded depression or with frequently swinging moods, not responding to other treatments.
>
> From the British Medical Journal, 1994
Posted by neuroscience on October 20, 2012, at 7:38:35
In reply to Timeline of psychopharmacology, posted by jono_in_adelaide on October 19, 2012, at 18:09:04
I like antiquity the best :)
Posted by bleauberry on October 20, 2012, at 13:10:34
In reply to Timeline of psychopharmacology, posted by jono_in_adelaide on October 19, 2012, at 18:09:04
Well, not sure if any were missed, but the antique category wasn't accurate. There are plant medicines, mostly ones not commonly heard of, that have been in use for at least 2000 years. Something doesn't keep getting used that long if it is a dud. The only ones mentioned in the antique category were ones that produce a high. Some of these herbs work similar to antidepressants, most work differently, and all have a multitude of different mechanisms built in. These I think are better alternatives than meds because they don't just address symptoms. But they got lost in history when the profits of chemicals took the stage. They are still commonly available and used around the world by millions. Personally I think the best strategies involve combinations of western medicines and plant medicines. Anyone limiting themselves to just one toolbox I think reduce their chances of having a smoother journey. imo
Posted by jono_in_adelaide on October 22, 2012, at 2:04:54
In reply to Re: Timeline of psychopharmacology, posted by bleauberry on October 20, 2012, at 13:10:34
I'm happy to use any herbal medicine that has been subjected to randomised, double blind, placebo controlled trials (morphine for pain, pseudoephedrine for nasal congestion, atropine for cramps etc) but i am rather sceptical about a lot of them
This is the end of the thread.
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