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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by thefan on May 15, 2012, at 16:39:51
Hi
I have read this forum in the past but i decided to make my first formal post now as im again suffering from horrible problems with my mental health ;(
My medication is as follows. 750mg lyrica per day divided to 3 doses, a very small dose about 5mg mirtazapine, and a very small dose of trazodon hydrochlorid. 25mg or so. These are for gad/panic disorder.
I have been doing very fine with this medication for the past 3 years. Before this i was only on remeron and with the small dose.
My brain is peculiar, because for some reason benzodiazepines work only a matter of few days. I have not heard of any other person whose brain works this way, but maybe there are some. Anyway if i start to use a specific benzodiazepine, i develop tolerance extremely fast. Well i dont really know if its tolerance , because it occurs in a matter of days. For example to use a sleep medicine like imovane, i take 7,5mg, but the next day i cannot get to sleep unless i take that as double ;(.
Same is with regular benzodiazepines like klonopin. I only get the "benefits" for a matter of few days / week, and then i have to be withouth the medicine for about 2 weeks before i can start to use it again. If i use 2 different gaba bending benzos i will get a bit more benefit, but all in all i cannot use them for more then a few days. Maybe this has something to do with the gaba levels in my brain, or i dont know.The worsening of anxiety into full blown panic happened this week when i have discontinued panacod (used it for 2 days), and pronaxen (pain med). I have had problem with my prostate and took these to handle that pain area. I have only had prostate problems for 2 months, and i have been panicking about my prostate, but i think i have really been having these anxiety symptoms for 2 months that caused my prostate to be painfull, and in vice versa the prostate caused my brain to be panicky ;(.
I believe the pronaxen is still causing my brain to feel somewhat foggy, even though its just a regular medication for pain.
Anyway back to business. Most serotonergic meds have been really bad for my problems. They have just caused my problems to go 1000x worse to a point i cannot even function. These low doses make me feel a bit tired, which appears to have worked in my case. I have also heard these two drugs i mentioned work with the same receptors in the brain , i dont know on what particular receptor , but there is something good with these drugs, except not on high doses, then they make me feel more anxious like other serotonergic drugs.
I must add that more then 3 years ago my klonopin dosage rose within a period of about 3-4 months to an unimaginable level of about 6-7 mg per day , and i came off it pretty much cold turkey with the help of lyrica which i have continued to use since then.
Do you guys here at the babble have any idea which meds could possibly work with the same receptors as mirtazapine and trazodone? A 3rd drug with that category might come into question.
Lyrica seems to take most of the physical trouble as muscle pain to go away and with this high dose it also usually makes me feel more energetic. So i think ill keep it.
Any chance of suggesting any meds for my panic/gad? Meds seem to be the only thing that help me deal with these problems. I have had some therapy but it really as not for me as i have really intense physical problems like the pain in my chest and legs and arms and fear of something, and sometimes insomnia. Never had that with my current meds until now. For now i think i may have to try klonopin for a few days cos i know it will work for a few days, but after that it will again stop working as several times before.
Posted by GoddamnElectric on May 15, 2012, at 17:19:45
In reply to gad/panic Medication (new member), posted by thefan on May 15, 2012, at 16:39:51
After reading over your post, I'm wondering if perhaps you should be more thoroughly tested for a variety of ills.
Have you been given a full blood count, hormone levels, thyroid.... do you have symptoms of sleep apnea? I would ask for a range of diagnostics before changing anything around. Talk to your doctor about this, naturally.
Are you eating and sleeping well, taking vitamins and trying to exercise?
All the best!
Posted by thefan on May 16, 2012, at 17:29:26
In reply to Re: gad/panic Medication (new member), posted by GoddamnElectric on May 15, 2012, at 17:19:45
I have been tested for variety of illnesses. Thyroid was fine when last tested. Hormone levels have not been tested. Blood count is fine, i have no sleep apnea.
During the day time i can manage the panic somewhat, but if sleeping is not working as it should then i have no energy during the day and the panic gets even worse. Remember at this point im not taking any sleep meds because of fear of getting addicted to likes of klonopin/imovane etc. Well now im taking klonopin, but havent used that for years. Just trying to calm myself for couple of days.
Im eating quite well, and i play floorball 3 times a week,(its basically game like ice hockey but inside with a ball). so i do excercice except when my symptoms are really bad.
Iam more looking to some kind of advice on what meds to try for my panic/gad.
Posted by thefan on May 16, 2012, at 17:31:25
In reply to Re: gad/panic Medication (new member), posted by thefan on May 16, 2012, at 17:29:26
I know there are smililarities with receptor bindigs of tradozone and remeron , which i both use with low dose. Just wondering what receptors are causing the sleep effects of those meds.
Posted by GoddamnElectric on May 16, 2012, at 17:41:48
In reply to Re: gad/panic Medication (new member), posted by thefan on May 16, 2012, at 17:31:25
> I know there are smililarities with receptor bindigs of tradozone and remeron , which i both use with low dose. Just wondering what receptors are causing the sleep effects of those meds.
>
>
>
>The histiminergic properties of those drugs are what is helping you sleep. The drowsiness is more pronounced on lower doses of mirtazapine, this drowsiness can be useful to some because it helps alleviate anxiety/panic symptoms, even though this is not the best way to go about anxiety relief. The best thing would be normal vigilance, alertness, wakefulness etc while keeping your anxiety at bay. Meds are imperfect unfortunately.
This might sound odd, but go and buy yourself a bodybuilding protein supplement with all the added amino acids. Drink that a few times a day and see if your symptoms improve.
Posted by thefan on May 17, 2012, at 15:24:51
In reply to Re: gad/panic Medication (new member), posted by GoddamnElectric on May 16, 2012, at 17:41:48
I dont quite follow your suggestion, how might they help? Im wondering if my anxiet/panic could have come back from the use of antibiotic ciprafloxecin. I have readon some boards now that it might cause anxiety on some people.
thefna
Posted by thefan on May 19, 2012, at 15:49:57
In reply to Re: gad/panic Medication (new member), posted by thefan on May 17, 2012, at 15:24:51
How might the amino acids help? Anyway an update, im still on clonazepam for 4th day, this time it seems to be working atleast a little longer. Anyway i am going to discontinue it tomorrow and see how it goes withtouth it.
Do could you guys give comments on the following meds i have searched.
agomelantine (valdoxan)
oxcarbazepine in rapid benzodiazepine withdrawal
(effective). pubmedafobazol similar to agomelantine (Russian). over the counter
rhodiola ehkä (supplement) higher dose calms smaller energises.
captodiame tireing antihistamine seems to work on similar receptors then remeron etc.
pherinamine antihistamine.
Pivagabine:antidepressant and anxiolytic drug introduced in italy)
dicycloverin (its liquid, but not know what it contains).
oppipramol approved for gad in germany.
tofisopan (Emandaxin and Grandaxin) names, tranquilizer with claims to have no withdrawal cognitive or sedative functions (i wouldnt bet on this though).
mepiprazole
pitofizen some tiring drug.
Risperdal antipsychotic , pretty scared on trying but on very low dose maybe. Seems to work on same receptors then azona and mirtazon.
ketanserin blocks both 5ht2c että 5ht2a receptors as mirtazon and azona.
aniracetam/oxiracetam
cymbalta (duloxetine).
And then last but not least the maoi:s with their very high side effects (parnate, nardil).
The other option is adding some neurontin to my lyrica cocktail ;(.
Maybe you now understand that i want to know what meds could work best for me, as the psych docs here in finland don't seem to know jack sh*t and just pump me with meds i cant function at all.
Posted by CaffeinePoet on May 20, 2012, at 18:27:29
In reply to gad/panic Medication (new member), posted by thefan on May 15, 2012, at 16:39:51
Serzone is related to Trazodone.
Posted by thefan on May 23, 2012, at 18:26:26
In reply to Re: gad/panic Medication (new member) » thefan, posted by CaffeinePoet on May 20, 2012, at 18:27:29
Yes but i believe its not available in finland at the moment. Im looking for only drugs that do not increase serotonin levels.
So far i have found these drugs that some of them are not even thought as psychiatric drugs, but some are antihistamines that reduce anxiety somewhat.
Agomelantine (antidepressant/anxiety med).
afobazol (similar to agomelantine available over the counter in russia ;)
captodiame (antihistamine)
pherinamine (antihistamine)
pivagabine (antidepressant and anxiolytic drug introduced in italy)
disykloveren (this is some sort of liquid , i dont know how it works, but some psych docs use it with benzos i have heard).
oppipramol (drug for gad, atleast available in germany).
tofisopan (bran names emandaxin and grandain), benzo related drug, but says there are no side effects (highly doubt it).
pitofizen.
Risperdal with very low dose 25mg etc.
ketanserin (blocks 5ht2c and 5ht2a receptors, i think its similar to risperdal). low dose.
aniracetam/oxiracetam
cymbaltaThats quite a long list, what thoughts do you guys have on the meds on my to maybe try list?
Posted by thefan on May 30, 2012, at 12:47:57
In reply to Re: gad/panic Medication (new member), posted by thefan on May 23, 2012, at 18:26:26
Ok. Back to business. What do you guys think are currently the best panic medications available if you level out the tranquilizers.
These constant panic attacks that happen on a day to day basis are just so meaningful that it is really hard to live ;(
I am currently only on the medication that i previously posted which are 750mg of lyrica, and small doses of azona and mirtazapine.
I was on 7,5mg mirtazapine alone for a few years, and it conquered half of my attacks. When i added lyrica and azona later it seemed like a perfect cocktail.Medicine previously tried. Nefadar (serzone) big dose. Celexa , buspar, and possibly another antidepressant.
Are there any other medication that would possibly make panic attacks go away within a few days then the tranquilizers i fear, and if you would add something to my current cocktail and not take anything away what would it be?
I have heard that clonidine has had some pretty good feedback with panic attacks, but the psych doc i today went didn't want to prescribe it to me, and gave some rivatril instead , which i have not started to use atleast yet. Im trying to cope withouth the tranquilizers, but if you get close 1-2 fullblown attacks per day + some minor ones it is harddddddd.
This is the end of the thread.
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