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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by kagome on March 18, 2012, at 21:44:25
So, turns out that "atypical" depression is the most common depression subtype, which makes "atypical" seem like somewhat of a misnomer, eh?
Anyway, I fit the atypical depression thing pretty well so I've been looking it up and found that according to the research, tricyclics are pretty much pointless and SSRI's aren't much better (I'm exaggerating, of course, but not by much). Why hasn't any psych doctor mentioned this before? I've totally wasted my time trying tricyclics and trying to explain that SSRIs don't do much for me. However, I'm still having a hard time on Parnate and since sleepiness and weight gain are already an issue Nardil is the last thing I want to try. So I'm going to keep looking to alternatives. Right now I'm thinking of Low Dose Naltrexone, except I seem to really respond to the dopaminagenic properties of Abilify and of course Naltrexone is a dopamine antagonist. How I wish I had a doctor that would prescribe Buprenorphine or something similar although it would probably poop out pretty quickly...
So for all you atypicals out there, here's some bedtime reading:
http://en.wikipedia.org/wiki/Atypical_depression
http://depression.about.com/cs/diagnosis/a/atypicaldepress.htm
http://www.livestrong.com/article/8317-manage-atypical-depression/
unfortunately I can't figure out how to do links here, so you'll have to copy and paste...Good night everyone and good luck!
-kagome
Posted by Phillipa on March 18, 2012, at 22:04:46
In reply to Atypical Depression, posted by kagome on March 18, 2012, at 21:44:25
The links work. You did them correctly. Phillipa
Posted by SLS on March 19, 2012, at 7:18:01
In reply to Atypical Depression, posted by kagome on March 18, 2012, at 21:44:25
> and of course Naltrexone is a dopamine antagonist.
Are you sure? I didn't think naltrexone interacted directly with dopamine receptors at all. I could be wrong.
Why do you think that buprenorphine would poop-out (tachyphylaxis)? I think my doctor would agree with you, but I am not so sure.
Marplan?
- Scott
Posted by kagome on March 20, 2012, at 22:18:32
In reply to Re: Atypical Depression » kagome, posted by SLS on March 19, 2012, at 7:18:01
> Are you sure? I didn't think naltrexone interacted directly with dopamine receptors at all. I could be wrong.
Well, supposedly naltrexone works by messing with the dopaminergic mesolimbic pathway, which includes dopmine and opiod receptors.
> Why do you think that buprenorphine would poop-out (tachyphylaxis)? I think my doctor would agree with you, but I am not so sure.
Cause it's an opioid, so one would develop tolerance and it would no longer work in the same way. Especially for an ex-opioid addict like I am (I believe I became addicted to pain relievers as a self medication technique that ended up making everything worse - this was ten years ago, btw, when I was 18, so I've been "clean" for some time)
> Marplan?
Never heard of it, but definitely sounds interesting. Do you know anyone who's tried it? Or what the side effect profile is like? I'm not happy about the weight gain part they mention but I suppose I should have better priorities. I'm so impressed with the amount of info you have!
Thanks so much,
kagome
This is the end of the thread.
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