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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by n_shrimpie on February 6, 2012, at 17:55:05
I've been on abilify 2mg for one week, and 5 days ago upped it to 5mg. Bad akathisia for the first 10 days and insomnia (yet i never became tired despite the lack of sleep) but my motivation increased tenfold and i've been MUCH more productive at work. Today the akathisia disappeared, but i'm also totally unmotivated. Why am i less motivated and more tired on the higher dosage? Shouldn't it be the opposite? I'm also on 10mg prozac and 400 mg lamictal.
Posted by tensor on February 7, 2012, at 4:36:08
In reply to abilify dosage akathisia insomnia, posted by n_shrimpie on February 6, 2012, at 17:55:05
> I've been on abilify 2mg for one week, and 5 days ago upped it to 5mg. Bad akathisia for the first 10 days and insomnia (yet i never became tired despite the lack of sleep) but my motivation increased tenfold and i've been MUCH more productive at work. Today the akathisia disappeared, but i'm also totally unmotivated. Why am i less motivated and more tired on the higher dosage? Shouldn't it be the opposite? I'm also on 10mg prozac and 400 mg lamictal.
It can be more activating at lower doses. Maybe try 2mg again? Or split a 5mg pill to get 2.5mg. It takes more than two weeks for this drug to reach steady state so one has to patient about dose changes.
/t
Posted by novelagent on February 8, 2012, at 18:33:56
In reply to abilify dosage akathisia insomnia, posted by n_shrimpie on February 6, 2012, at 17:55:05
It reduces d1 dopamine receptor levels, which is good, because too much d1 causes psychosis, but it also, as a side-effect, decreases d2 dopamine receptor levels, which causes the negative symptoms of schizophrenia to worsen (apathy, anhedonia, etc.).
Taking a stimulant like Vyvanse increases prefrontal cortex dopamine levels, serving as a nice complement to an antipsychotic.
> I've been on abilify 2mg for one week, and 5 days ago upped it to 5mg. Bad akathisia for the first 10 insomnia (yet i never became tired despite the lack of sleep) but my motivation increased tenfold and i've been MUCH more productive at work. Today the akathisia disappeared, but i'm also totally unmotivated. Why am i less motivated and more tired on the higher dosage? Shouldn't it be the opposite? I'm also on 10mg prozac and 400 mg lamictal.
This is the end of the thread.
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