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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on December 7, 2011, at 16:35:21
It appears possible to reverse tolerance to benzodiazapines with intermittant use of a benzodiazapine antagonist (at least in terms of epileptic seizures). I wonder if the same would apply to simply drinking coffee (a source of the benzodiazapine antagonist beta carboline?)
http://www.thelancet.com/journals/lancet/article/PII0140-6736(91)90799-U/abstract
When 3 patients with partial seizures who had become tolerant to clonazepam were given 1·5 mg flumazenil, they were seizure-free for 6-21 days after the injection. The value of intermittent therapy with a benzodiazepine antagonist for preventing or reversing tolerance to benzodiazepine agonists ought to be investigated further.
Posted by ed_uk2010 on December 7, 2011, at 17:14:58
In reply to reversing benzodazapine tolerance (for real?), posted by linkadge on December 7, 2011, at 16:35:21
It's an extremely interesting study... but surely flumazenil cannot be compared with coffee.
Posted by Phillipa on December 7, 2011, at 20:22:18
In reply to reversing benzodazapine tolerance (for real?), posted by linkadge on December 7, 2011, at 16:35:21
What is it new computer haven't figured out how to google just home with it? PJ
This is the end of the thread.
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