Posted by linkadge on December 7, 2011, at 16:35:21
It appears possible to reverse tolerance to benzodiazapines with intermittant use of a benzodiazapine antagonist (at least in terms of epileptic seizures). I wonder if the same would apply to simply drinking coffee (a source of the benzodiazapine antagonist beta carboline?)
http://www.thelancet.com/journals/lancet/article/PII0140-6736(91)90799-U/abstract
When 3 patients with partial seizures who had become tolerant to clonazepam were given 1·5 mg flumazenil, they were seizure-free for 6-21 days after the injection. The value of intermittent therapy with a benzodiazepine antagonist for preventing or reversing tolerance to benzodiazepine agonists ought to be investigated further.
poster:linkadge
thread:1004402
URL: http://www.dr-bob.org/babble/20111120/msgs/1004402.html