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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by crazyjoe on August 9, 2011, at 22:03:48
how would you rate the ssri's in terms of potency with the most potent first
Posted by Phillipa on August 9, 2011, at 23:56:15
In reply to ssri's /potency, posted by crazyjoe on August 9, 2011, at 22:03:48
Tough to answer as we are all different and treating different things as some more for anxiety, some, depression more, and some people need more norephenprine than others. I know the strongest for me was prozac as increased anxiety. Some say effexor? I wonder what a google search would say. And the norephenprine would be an SNRI not an SSRI. Phillipa
Posted by crazyjoe on August 10, 2011, at 9:12:34
In reply to Re: ssri's /potency » crazyjoe, posted by Phillipa on August 9, 2011, at 23:56:15
do yooooooou think noreprinephrine helps people with bipolar/ocd took cymbalta for 8 months think it turned me around sometimes...am know on 40 celexa only for 3 weeks ....does the sweatin stop over time....did u like cymbalta
Posted by Phidippus on August 10, 2011, at 19:03:57
In reply to ssri's /potency, posted by crazyjoe on August 9, 2011, at 22:03:48
There's no way to measure potency, but I'm sure there's some study out their that has studied efficacy-for instance I know Prozac scores a little higher in treating OCD than Luvox.
P
Posted by jono_in_adelaide on August 10, 2011, at 19:37:02
In reply to ssri's /potency, posted by crazyjoe on August 9, 2011, at 22:03:48
ESCITRALOPRAM AND SERTRALINE FIRST
CITRALOPRAM AND PAROXETINE SECOND
FLUOXETINE LAST
Posted by Phillipa on August 10, 2011, at 19:58:19
In reply to Re: ssri's /potency, posted by jono_in_adelaide on August 10, 2011, at 19:37:02
Where did you find this info? Seriously? Phillipa
Posted by jono_in_adelaide on August 11, 2011, at 1:07:31
In reply to Re: ssri's /potency » jono_in_adelaide, posted by Phillipa on August 10, 2011, at 19:58:19
Of course the infomation applies to groups, not indiciduals (if 1000 people are treated with Zoloft and 1000 are treated with Prozac, more in the Zoloft group will likely respont), it doesnt mean that Zoloft is the strongest drug for you, or the best drug for everyone.
Averages can conceal as much as they reveal!
Posted by bleauberry on August 12, 2011, at 17:52:29
In reply to ssri's /potency, posted by crazyjoe on August 9, 2011, at 22:03:48
I have seen some potency charts somewhere. I think the order was paxil strongest, then lexapro, zoloft. Not sure about the others. In my own experience with all of them I would agree with paxil being the most potent, but prozac the most effective. imo
The way they measure potency is by how strong the affinity of the drug is to its target receptors. But it doesn't tell us anything about the myriad of ways the meds manipulate all kinds of other physiological systems within us, which may or may not play a major role in the remission or not. So merely looking at potency as a measuring stick I don't think tells the whole story.
Posted by Conundrum on August 13, 2011, at 8:54:25
In reply to Re: ssri's /potency, posted by bleauberry on August 12, 2011, at 17:52:29
> I have seen some potency charts somewhere. I think the order was paxil strongest, then lexapro, zoloft. Not sure about the others. In my own experience with all of them I would agree with paxil being the most potent, but prozac the most effective. imo
>
> The way they measure potency is by how strong the affinity of the drug is to its target receptors. But it doesn't tell us anything about the myriad of ways the meds manipulate all kinds of other physiological systems within us, which may or may not play a major role in the remission or not. So merely looking at potency as a measuring stick I don't think tells the whole story.Yes, there are different ways to talk about potency. You could say which is the most potent 5HT reuptake inhibitor? In which Paxil probably wins because it is the tool that labs use to determine how strongly other drugs bind to the serotonin transporter. Then you could ask, which drug is most selective, meaning which drug increases serotonin the most in relationship to the drugs effects on other genes, in which case Lexapro seems to be the most selective. Which is most effective? That's the hard part and most doctors will have a favorite.
Posted by viper1431 on August 13, 2011, at 11:23:36
In reply to ssri's /potency, posted by crazyjoe on August 9, 2011, at 22:03:48
potency on seratonin:
Sertraline 0.19 0.85 3.40
Paroxetine 0.29 0.44 0.73
Clomipramine 1.50 2.25 --
Citalopram 1.80 2.71 --
Fluvoxamine 3.80 3.08 --
Fluoxetine 6.8 87.0 93.0
Imipramine 35.00 31.80 41.00
Amitriptyline 39.00 67.20 84.00
Desipramine 200.00 182.00 180.00
http://www.preskorn.com/books/ssri_s3.html> how would you rate the ssri's in terms of potency with the most potent first
Posted by crazyjoe on August 13, 2011, at 12:14:56
In reply to Re: ssri's /potency » crazyjoe, posted by viper1431 on August 13, 2011, at 11:23:36
don't understand this at all--in simple terms can you relate that to me strongest to weakest
Posted by SLS on August 13, 2011, at 12:17:54
In reply to Re: ssri's /potency » bleauberry, posted by Conundrum on August 13, 2011, at 8:54:25
> > I have seen some potency charts somewhere. I think the order was paxil strongest, then lexapro, zoloft. Not sure about the others. In my own experience with all of them I would agree with paxil being the most potent, but prozac the most effective. imo
> >
> > The way they measure potency is by how strong the affinity of the drug is to its target receptors. But it doesn't tell us anything about the myriad of ways the meds manipulate all kinds of other physiological systems within us, which may or may not play a major role in the remission or not. So merely looking at potency as a measuring stick I don't think tells the whole story.
>
> Yes, there are different ways to talk about potency. You could say which is the most potent 5HT reuptake inhibitor? In which Paxil probably wins because it is the tool that labs use to determine how strongly other drugs bind to the serotonin transporter. Then you could ask, which drug is most selective, meaning which drug increases serotonin the most in relationship to the drugs effects on other genes, in which case Lexapro seems to be the most selective. Which is most effective? That's the hard part and most doctors will have a favorite.
Exactly.
- Scott
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