Posted by SLS on August 13, 2011, at 12:17:54
In reply to Re: ssri's /potency » bleauberry, posted by Conundrum on August 13, 2011, at 8:54:25
> > I have seen some potency charts somewhere. I think the order was paxil strongest, then lexapro, zoloft. Not sure about the others. In my own experience with all of them I would agree with paxil being the most potent, but prozac the most effective. imo
> >
> > The way they measure potency is by how strong the affinity of the drug is to its target receptors. But it doesn't tell us anything about the myriad of ways the meds manipulate all kinds of other physiological systems within us, which may or may not play a major role in the remission or not. So merely looking at potency as a measuring stick I don't think tells the whole story.
>
> Yes, there are different ways to talk about potency. You could say which is the most potent 5HT reuptake inhibitor? In which Paxil probably wins because it is the tool that labs use to determine how strongly other drugs bind to the serotonin transporter. Then you could ask, which drug is most selective, meaning which drug increases serotonin the most in relationship to the drugs effects on other genes, in which case Lexapro seems to be the most selective. Which is most effective? That's the hard part and most doctors will have a favorite.
Exactly.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:993350
URL: http://www.dr-bob.org/babble/20110809/msgs/993640.html