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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by poser938 on May 8, 2011, at 19:56:02
so, im about to begin taking an antipsychotic and was wondering how long it takes beofore you start to notice any tolerance to the effects of it? im actually going to be taking it just to increase dopamine receptor sensitivity, because mirapex seems to have completely desensitized my dopamine receptors chronically. this is the idea my doc and i came up with. and i know everyone is different, but how long til you noticed any tolerance to an antipsychotic?
Posted by Zyprexa on May 9, 2011, at 21:35:33
In reply to antipsychotic tolerance, posted by poser938 on May 8, 2011, at 19:56:02
I take zyprexa and in 13 years have never built up a tolarance to it untill I took the abilify. After that I went back on zyprexa and it was not as powerfull as it was.
Posted by B2chica on May 10, 2011, at 8:44:47
In reply to Re: antipsychotic tolerance, posted by Zyprexa on May 9, 2011, at 21:35:33
i have been off and on periodically since 2003. i have never built up a tolerance. and the best part is after pregnancies i was still able to go back on it and have it work like a charm.
b2c.trying out perphenazine now. been on it for a month. i'll let you know on this one but dont forsee tolerance either.
Posted by Christ_empowered on May 10, 2011, at 15:55:00
In reply to antipsychotic tolerance, posted by poser938 on May 8, 2011, at 19:56:02
I take Abilify, which is kind of an odd drug, but...I haven't noticed much in the way of tolerance. When I go off of it, I initially require higher doses to get stable, but that's probably due to psychological/psychiatric factors and b/c Abilify isn't sedating (great for long-term, not the best for short-term monotherapy).
Anyway, I think your brain starts increasing D2 receptor density after a couple weeks of treatment. I could be wrong, but I think that's why some people are on side-effect meds early on and then they're able to taper off of those...the brain adapts. I imagine SLS would know more about that, though.
Posted by poser938 on May 10, 2011, at 16:49:15
In reply to antipsychotic tolerance, posted by poser938 on May 8, 2011, at 19:56:02
thanks for your responses you guys:)
This is the end of the thread.
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