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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Phillipa on April 11, 2011, at 0:09:15
Is regular luvox different then other SSRI's? I was told it is but have no idea why. Can someone please explain how it is different? Phillipa
Posted by desolationrower on April 11, 2011, at 5:51:02
In reply to Luvox A Different SSRI Than Others Why??????, posted by Phillipa on April 11, 2011, at 0:09:15
its pretty selective, afaik.
it does *something* at the sigma 1 receptor, i've seen both agonist or antagonist. which one doesn't really matter, since noone is quite sure what that receptor does.
-d/r
Posted by Phillipa on April 11, 2011, at 13:02:36
In reply to Re: Luvox A Different SSRI Than Others Why??????, posted by desolationrower on April 11, 2011, at 5:51:02
d/r what do you think of luvox in your opinion only of course? How come my body seems to need 50mg and yet does nothing? Thanks Phillipa
Posted by desolationrower on April 14, 2011, at 1:42:44
In reply to Re: Luvox A Different SSRI Than Others Why?????? » desolationrower, posted by Phillipa on April 11, 2011, at 13:02:36
> d/r what do you think of luvox in your opinion only of course? How come my body seems to need 50mg and yet does nothing? Thanks Phillipa
Its hard to know if a medication is right for someone, even if you've tried it.
-d/r
Posted by Brainbeard on April 15, 2011, at 3:27:27
In reply to Luvox A Different SSRI Than Others Why??????, posted by Phillipa on April 11, 2011, at 0:09:15
> Is regular luvox different then other SSRI's? I was told it is but have no idea why. Can someone please explain how it is different? Phillipa
Luvox is unique in that it's a very strong inhibitor of a group of enzymes called (CYP) 1A2. This has the effect of raising melatonin levels considerably, since melatonin is broken down by 1A2. Melatonin, 'the sleep hormone', has a broad spectrum of actions - it may cause drowsiness, but may also improve nighttime sleep; it even has neuroprotective properties, so Luvox may be good for your brain.
Another substance broken down by 1A2 is caffeine,; Luvox potentiates your cup of joe about sixfold.
Posted by mtdewcmu on April 15, 2011, at 8:57:35
In reply to Re: Luvox A Different SSRI Than Others Why??????, posted by Brainbeard on April 15, 2011, at 3:27:27
> > Is regular luvox different then other SSRI's? I was told it is but have no idea why. Can someone please explain how it is different? Phillipa
>
> Luvox is unique in that it's a very strong inhibitor of a group of enzymes called (CYP) 1A2. This has the effect of raising melatonin levels considerably, since melatonin is broken down by 1A2. Melatonin, 'the sleep hormone', has a broad spectrum of actions - it may cause drowsiness, but may also improve nighttime sleep; it even has neuroprotective properties, so Luvox may be good for your brain.
>
> Another substance broken down by 1A2 is caffeine,; Luvox potentiates your cup of joe about sixfold.You are quite right about these interactions. Thank you for posting this. I wasn't very familiar with CYP1A2 and its substrates.
A professional resource I consulted showed that Luvox can increase mirtazapine concentrations by 3-4x and melatonin by 12x when taking a melatonin supplement.
Posted by hopefullynow on April 15, 2011, at 10:54:31
In reply to Re: Luvox A Different SSRI Than Others Why??????, posted by mtdewcmu on April 15, 2011, at 8:57:35
What about 50 mg Luvox combined with 400 mg carbamazepine, 1 mg Clonazepam and 1 mg Risperidone?
Are there any interactions?Also i smoke about 1 package of cigarettes by day.
Never really understood the enzymes thing :)
Posted by Brainbeard on April 15, 2011, at 16:45:43
In reply to Re: Luvox A Different SSRI Than Others Why??????, posted by hopefullynow on April 15, 2011, at 10:54:31
> Are there any interactions?Also i smoke about 1 package of cigarettes by day.
>Smoking does the exact opposite of inhibiting 1A2: it induces 1A2. That's why smokers drink excessive amounts of coffee. Their caffeine is broken down much quicker. Smoking will lower Luvox blood levels considerably, and blood levels of most TCA's moderately. Needless to say perhaps, it will also lower melatonin levels.
Posted by mtdewcmu on April 15, 2011, at 17:55:07
In reply to Re: Luvox A Different SSRI Than Others Why??????, posted by hopefullynow on April 15, 2011, at 10:54:31
> What about 50 mg Luvox combined with 400 mg carbamazepine, 1 mg Clonazepam and 1 mg Risperidone?
>
> Are there any interactions?Also i smoke about 1 package of cigarettes by day.
>
> Never really understood the enzymes thing :)
>I think you will find multiple interactions there if you do a little digging. Carbamazepine is also an enzyme inducer along with smoking.
Posted by Phillipa on April 15, 2011, at 20:23:55
In reply to Re: Luvox A Different SSRI Than Others Why??????, posted by Brainbeard on April 15, 2011, at 3:27:27
Brainbeard think this why the abrupt removal of 50mg of luvox and adding of high doses of benzos kept me awake and no sleep for two weeks. ER and docs said go back on and then the l0mg of valium and 50mg of luvox let me sleep again? Think I'd be better off raising luvox instead of adding low doses of lexapro? Thanks Phillipa
This is the end of the thread.
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