Posted by mtdewcmu on April 15, 2011, at 8:57:35
In reply to Re: Luvox A Different SSRI Than Others Why??????, posted by Brainbeard on April 15, 2011, at 3:27:27
> > Is regular luvox different then other SSRI's? I was told it is but have no idea why. Can someone please explain how it is different? Phillipa
>
> Luvox is unique in that it's a very strong inhibitor of a group of enzymes called (CYP) 1A2. This has the effect of raising melatonin levels considerably, since melatonin is broken down by 1A2. Melatonin, 'the sleep hormone', has a broad spectrum of actions - it may cause drowsiness, but may also improve nighttime sleep; it even has neuroprotective properties, so Luvox may be good for your brain.
>
> Another substance broken down by 1A2 is caffeine,; Luvox potentiates your cup of joe about sixfold.You are quite right about these interactions. Thank you for posting this. I wasn't very familiar with CYP1A2 and its substrates.
A professional resource I consulted showed that Luvox can increase mirtazapine concentrations by 3-4x and melatonin by 12x when taking a melatonin supplement.
poster:mtdewcmu
thread:982442
URL: http://www.dr-bob.org/babble/20110406/msgs/982900.html