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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by greenwillow on January 15, 2011, at 1:38:50
I am struggling with disabling depression and alot of anxiety that has raised my adrenaline enough to give me serious heart palpitations. Saw family doctor today and she said I should be on an antidepressant with some, if not all, norepinephrine. What is it exactly about norepinephrine that I would benefit specifically from it?
Posted by SLS on January 15, 2011, at 4:49:08
In reply to Norepinephrine, posted by greenwillow on January 15, 2011, at 1:38:50
> I am struggling with disabling depression and alot of anxiety that has raised my adrenaline enough to give me serious heart palpitations. Saw family doctor today and she said I should be on an antidepressant with some, if not all, norepinephrine. What is it exactly about norepinephrine that I would benefit specifically from it?
I think a great many of us would like to know the answer to that question. Do you feel comfortable enough with your doctor to ask him?
- Scott
Posted by greenwillow on January 22, 2011, at 20:11:33
In reply to Re: Norepinephrine, posted by SLS on January 15, 2011, at 4:49:08
> > I am struggling with disabling depression and alot of anxiety that has raised my adrenaline enough to give me serious heart palpitations. Saw family doctor today and she said I should be on an antidepressant with some, if not all, norepinephrine. What is it exactly about norepinephrine that I would benefit specifically from it?
>
> I think a great many of us would like to know the answer to that question. Do you feel comfortable enough with your doctor to ask him?
>
>
> - ScottThen I mentioned my depression to another doctor and she specifically said to avoid norepinephrine. The second one said to take a tiny amount of SSRI. So I have begun taking about 5 mg. of Celexa, which has helped take the edge off the depression.
Posted by creepy on January 31, 2011, at 11:43:45
In reply to Re: Norepinephrine » SLS, posted by greenwillow on January 22, 2011, at 20:11:33
NE does tend to raise physical anxiety symptoms a bit. If you can tolerate this it can augment an SSRI nicely.
Deep, dark, brooding anxiety is a different type and can come from depression itself. That type seems to respond well to NE.
Posted by SLS on January 31, 2011, at 13:42:04
In reply to Re: Norepinephrine » SLS, posted by greenwillow on January 22, 2011, at 20:11:33
> Then I mentioned my depression to another doctor and she specifically said to avoid norepinephrine. The second one said to take a tiny amount of SSRI. So I have begun taking about 5 mg. of Celexa, which has helped take the edge off the depression.
Well, in that case, WOOHOO!
- Scott
Posted by Chairman_MAO on February 3, 2011, at 8:06:51
In reply to Re: Norepinephrine » SLS, posted by greenwillow on January 22, 2011, at 20:11:33
http://ajp.psychiatryonline.org/cgi/content/full/161/5/909
See "mechanisms of noradrenergic transmission". Gotta go, can talk more later.
Posted by medamorphosis on February 9, 2011, at 21:22:04
In reply to Norepinephrine, posted by greenwillow on January 15, 2011, at 1:38:50
Well for me, NE gives focus, motivation, concentration and stamina. Actually good for certain anxieties/depressions which often make the mind go blank. Seems to enhance cognitive abilities, especially in social anxiety. Tho it certainly dont exactly get rid of typical fears. But it should get you outa bed!
NRI: Reboxetine- little, if any mood lift but motivation, focus and stamina increase.
TCA NRI: Lofepramine (or desipramine, it's main metabolite)- mild yet persistant mood lift, motivation, stamina, focus and great with a benzo!
DNRI: Bupropion- mild mood lift of a different kind, more like a low dose amphetamine tho didn't last long enough. Still the motivation, focus and stamina increase, but pooped out too quickly.Others which increase NE as 'PART' of thier action are MAOIs, SNRIs and most TCAs. More probably.
Definitely best when part of a multi-action med or mixed action combo. And IMO forget venlafaxine! Just another SSRI in my book. And think twice before trying mirtazepine too- the NE effects only appear at higher than norm doses (low to norm doses usually make you 'zombified'). And very few docs like to prescribe high doses (45mg+), and even with a high dose theres no gaurantee of the fog dissappearing.
Tho velafaxine + mirtazepine is described by some pdocs as 'Rocket Fuel'! What causes this strong NE effect from the combo i do not know.Med
Posted by greenwillow on February 10, 2011, at 21:23:59
In reply to Re: Norepinephrine » greenwillow, posted by medamorphosis on February 9, 2011, at 21:22:04
I ended up on 30 mg. Cymbalta and that seems to be helping me.
This is the end of the thread.
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