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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Laney on January 30, 2011, at 13:42:16
I went up to 75mg. along with my 20mg. paxil because it no longer helped (nort.) and so far after close to two weeks the nort. is still not helping. Should I give it more time? It seems like it worked fairly quickly last time.
Thanks for your replies.
Laney
Posted by Conundrum on January 30, 2011, at 13:58:36
In reply to How long before I give up on Nortriptyline?, posted by Laney on January 30, 2011, at 13:42:16
Have you been on 75 mg for two weeks? Two weeks probably isn't long enough for a reuptake inhibitor type drug. I would give it another two weeks and maybe get drug levels tested.
>
I went up to 75mg. along with my 20mg. paxil because it no longer helped (nort.) and so far after close to two weeks the nort. is still not helping. Should I give it more time? It seems like it worked fairly quickly last time.
>
> Thanks for your replies.
>
> Laney
Posted by Laney on January 30, 2011, at 14:56:08
In reply to Re: How long before I give up on Nortriptyline?, posted by Conundrum on January 30, 2011, at 13:58:36
Yes, approx. two weeks at 75mg. But like I said it seemed to work much quicker when I first started it. Thanks! Yes, I will get levels tested.
P.S. Are tricyclics reuptake inhibitors?
Thanks!
Laney
Posted by Conundrum on February 1, 2011, at 20:28:28
In reply to Re: How long before I give up on Nortriptyline?, posted by Laney on January 30, 2011, at 14:56:08
> Yes, approx. two weeks at 75mg. But like I said it seemed to work much quicker when I first started it. Thanks! Yes, I will get levels tested.
>
> P.S. Are tricyclics reuptake inhibitors?
>
> Thanks!
>
> LaneyWith the exception of Tianeptine, almost all of the tricyclic antidepressants are reuptake inhibitors. Nortriptyline blocks the reuptake of norepinephrine fairly strongly and the reuptake of serotonin moderately. They do a lot of other things as well, but the reuptake type of mechanisms seem to take awhile to work. Blocking of postsynaptic receptors seems to work a lot faster like histamine making you tired and D2 blockade with antipsychotics works fairly quickly.
Posted by linkadge on February 5, 2011, at 13:47:44
In reply to Re: How long before I give up on Nortriptyline? » Laney, posted by Conundrum on February 1, 2011, at 20:28:28
>With the exception of Tianeptine,
and trimipramine.
Linkadge
This is the end of the thread.
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