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Re: How long before I give up on Nortriptyline? » Laney

Posted by Conundrum on February 1, 2011, at 20:28:28

In reply to Re: How long before I give up on Nortriptyline?, posted by Laney on January 30, 2011, at 14:56:08

> Yes, approx. two weeks at 75mg. But like I said it seemed to work much quicker when I first started it. Thanks! Yes, I will get levels tested.
>
> P.S. Are tricyclics reuptake inhibitors?
>
> Thanks!
>
> Laney

With the exception of Tianeptine, almost all of the tricyclic antidepressants are reuptake inhibitors. Nortriptyline blocks the reuptake of norepinephrine fairly strongly and the reuptake of serotonin moderately. They do a lot of other things as well, but the reuptake type of mechanisms seem to take awhile to work. Blocking of postsynaptic receptors seems to work a lot faster like histamine making you tired and D2 blockade with antipsychotics works fairly quickly.


Complaints: post-SSRI problems: anhedonia, memory and concentration problems, sexual anhedonia. )
Country:USA
Currently taking 2.5 mg prozac, Multi B vitamin

 

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