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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by atypical on August 29, 2010, at 23:36:22
In Stahl's Cambridge Online Prescriber's Guide I noticed this drug is listed for depression and dysthymia. And it acts on norepinephrine (not serotonin -- I take MAOI so wouldn't be able to take serotinergic drug). But, alas, it is not available in the US. Is it in process? Or is it just going to be a UK drug.
Atypical
Posted by weatherfreak on August 31, 2010, at 10:12:21
In reply to Reboxetine/Edronax, posted by atypical on August 29, 2010, at 23:36:22
> In Stahl's Cambridge Online Prescriber's Guide I noticed this drug is listed for depression and dysthymia. And it acts on norepinephrine (not serotonin -- I take MAOI so wouldn't be able to take serotinergic drug). But, alas, it is not available in the US. Is it in process? Or is it just going to be a UK drug.
>
> AtypicalI tried it in Australia but it pooped out very quickly, I think it's very similar to Strattera, someone correct me if I'm wrong. It had a very high side effect profile for me but it actually worked, and very quickly too. I put up with the side effects until it stopped working after about 3 months. I tried to augment it with lamictal but that didn't work either
Posted by SLS on August 31, 2010, at 11:18:00
In reply to Reboxetine/Edronax, posted by atypical on August 29, 2010, at 23:36:22
> In Stahl's Cambridge Online Prescriber's Guide I noticed this drug is listed for depression and dysthymia. And it acts on norepinephrine (not serotonin -- I take MAOI so wouldn't be able to take serotinergic drug). But, alas, it is not available in the US. Is it in process? Or is it just going to be a UK drug.
I haven't seen anything that would lead me to believe that reboxetine is being developed in the US for marketing. It doesn't seem to be as effective as desipramine, a TCA that is selective for NE reuptake inhibition. There are other pharmacological differences between the two drugs as well. It is difficult to pinpoint which properties are most important for its mechanisms of action as an antidepressant.
- Scott
Posted by Conundrum on August 31, 2010, at 11:30:48
In reply to Re: Reboxetine/Edronax » atypical, posted by SLS on August 31, 2010, at 11:18:00
Scott is right, reboxetine even has anticholinergic properties, so why waste money on that when you can get all the anticholinergic effects you may need from desipramine.
According to wiki, reboxetine increases orgasmic intensity. I've noticed that initially on pristiq, but not pure SSRIs. It seems for some norepinephrine is the answer to there problems, so why not ask your doctor about desipramine?
Posted by ed_uk2010 on August 31, 2010, at 12:55:34
In reply to Reboxetine/Edronax, posted by atypical on August 29, 2010, at 23:36:22
>Or is it just going to be a UK drug.
We have it, but hardly anyone takes it. Lofepramine (which is similar to desipramine) tends to be used more often.
Posted by pedr on August 31, 2010, at 14:50:58
In reply to Re: Reboxetine/Edronax, posted by ed_uk2010 on August 31, 2010, at 12:55:34
> >Or is it just going to be a UK drug.
>
> We have it, but hardly anyone takes it. Lofepramine (which is similar to desipramine) tends to be used more often.
>
>it sent me bonkers. 2 weeks of non-stop 24/7 obsessional suicidal ideation, incredible light sensitivity and a bunch of other intense s/e's. Not my cup of tea at all.
Pete
Posted by bleauberry on August 31, 2010, at 15:15:33
In reply to Reboxetine/Edronax, posted by atypical on August 29, 2010, at 23:36:22
In pbabble world this med hasn't worked out anywhere near as good as clinical trials would suggest. Makes one kind of wonder about the accuracy of those trials.
My own belief is that no NRI is likely to provide lasting relief.
I think the key is to have both sri and nri at the same time. Clomipramine is probably the only TCA that fits that description but side effects are kind of stiff.
Dr Gillman favored combos such as zoloft+nortriptyline or zoloft+reboxetine. Zoloft was the typical choice due to the fewest interactions or liver complications during combinations. The overall idea is....both norepinephrine and serotonin at the same time...not just one or the other. That said, in a combination it might work well. By itself, my gut instinct says no.
Posted by weatherfreak on August 31, 2010, at 20:31:02
In reply to Re: Reboxetine/Edronax » SLS, posted by Conundrum on August 31, 2010, at 11:30:48
> Scott is right, reboxetine even has anticholinergic properties, so why waste money on that when you can get all the anticholinergic effects you may need from desipramine.
>
> According to wiki, reboxetine increases orgasmic intensity. I've noticed that initially on pristiq, but not pure SSRIs. It seems for some norepinephrine is the answer to there problems, so why not ask your doctor about desipramine?Conundrum it doesn't just increase orgasmic intensity, it can actually make you have spontaneous orgasms. I had several while walking down the street, whilst totally unaroused. That is probably number one on the list of freaky side effects I have ever experienced.
Without trying to sound too graphic there was no erection involved and no warning, but full orgasmic sensation (so totally embarrassing) and messy. That did stop after 2 weeks. It was on the PI sheet and I couldn't believe it when it happened.
Posted by Conundrum on September 1, 2010, at 6:19:48
In reply to Re: Reboxetine/Edronax » Conundrum, posted by weatherfreak on August 31, 2010, at 20:31:02
Did it increase sensitivity in general as well?
Posted by weatherfreak on September 1, 2010, at 8:21:31
In reply to Re: Reboxetine/Edronax » weatherfreak, posted by Conundrum on September 1, 2010, at 6:19:48
> Did it increase sensitivity in general as well?
For me yes it did, very much so.
This is the end of the thread.
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