Psycho-Babble Medication Thread 955037

Shown: posts 1 to 6 of 6. This is the beginning of the thread.

 

Which AD has closest effect to Modafinil's

Posted by vic80 on July 19, 2010, at 17:20:05

After a few hours of mood elevation for 2 days on Modafinil 100 mg along with a boost in energy, i am wondering if there is an AD which has similar effects. Basically giving energy and mood elevation and hopefully without the nervous jittery feeling of Modafinil. Also need to address dissociative symptoms which could get worsened with the mad wired feeling that Modafinil causes.
Would Wellbutrin do the needful without the flatness of Ssri and snris and good anxiolytic effect as well.
My depression now seems to be mainly thought based rather much on mood. Tho it would be wrong to say its not mood related.
How long through treatment course does Modafinil continue to give the mood elevation without having to increase the dose.

 

Re: Which AD has closest effect to Modafinil's » vic80

Posted by Phillipa on July 19, 2010, at 18:08:36

In reply to Which AD has closest effect to Modafinil's, posted by vic80 on July 19, 2010, at 17:20:05

I just read that 200mg of providgil is the standard dose. Maybe increase to this dose? Phillipa

 

Re: Which AD has closest effect to Modafinil's

Posted by Christ_empowered on July 19, 2010, at 19:07:35

In reply to Re: Which AD has closest effect to Modafinil's » vic80, posted by Phillipa on July 19, 2010, at 18:08:36

I don't think bupropion is the best drug for anxiety, but it is a somewhat activating, stimulating antidepressant. If I recall correctly, its related to Tenuate, a mild stimulant diet pill.
Higher doses of effexor can be stimulating. Straterra failed trials for depression (that's why its being used for ADD now), but it is stimulating and might help you...some patients find it helps their depression, too.

good luck.

 

Re: Which AD has closest effect to Modafinil's

Posted by bleauberry on July 19, 2010, at 19:28:19

In reply to Which AD has closest effect to Modafinil's, posted by vic80 on July 19, 2010, at 17:20:05

I found modafinil's ancestor, adrafinil, to be a lot better. More subtle though, with a build-up time of a month or more, similar to antidepressants. Modafinil was more of a quick hitting stimulant, while adrafinil was smoother and took a while to kick in. And when it did, it was a lot better than modafinil. But we all respond differently. Who knows. Ritalin might be one to look at also.

 

MODAFINIL and ATIVAN together... good or bad? » bleauberry

Posted by vic80 on July 20, 2010, at 14:45:57

In reply to Re: Which AD has closest effect to Modafinil's, posted by bleauberry on July 19, 2010, at 19:28:19

> Modafinil was more of a quick hitting stimulant,

Hi Bleauberry,
Really glad to see your post here. I wonder if you chanced upon my posts about my progress with Milnacipran. After oscillating between 50 and 25mg, for 2 months with different results - I could not take the mind-numbing and mood-numbing effect it was having on me. It was making me very passive, hard hearted without anger but in general being dysphoric. Not to mention the energy levels were only physical. Mentally I would feel totally sleepy.
I am no on 25mg taken once in the night past 5 days.

Then after my suggestion of adding a stimulant, the doc decided to prescribe me Modafinil, which was a great thing because I had such good mood on it for the first 2 days - really nice mood elevation - not manic or euphoric - but nice enough to feel touched by things, feel motivated enough to go up and talk to people etc... and a feeling likea burden is off my head.... this would last for 2 hours.... after which would start this strange mental strait-jacket nervous stuck in the head feeling... which would make me unable to do anything... an ativan 0.5 in late ebening would calm me down but over all it made me feel overwhelmed... as though my state of consciousness changed... plus I would snap at anyone, feel some sort of righteous anger towards people.

on day 3 it just did nothing - only made me focussed and horribly enough focus inwards - made me obsessive and totally wired. .... towards evening I started to experience the dysphoric effect.... started to feel sick and horrible.... an atiivan in the night did nothing but infact made me feel more irritated.

2 days off modafinil and I was under severe anxiety - panic - impending doom - intrusive thots - dissociative feelings - as though I am not able to feel ok with my 'fine mood'....

So i call in the pdoc and she suggests I take only 50mg modafinil. Which I did, it kicked in quite late and the effect was just subtle mood elevation along with a sense of confidence in my own inner voice.... which anxiety had made me feel separatred from.
In the evening the panic and anxiety rushed to my head..... almost derealization like...I took a whole ativan 1mg.... in a while i calmed down to the point of feeling really good.... this felt like blissful joy.... which lasted for like 2 hours.... only to be replaced with the edgy wired feeling and futher on with dysphoria and fatigue - which could perhaps be called a crash?

I also find Modafinil to not purely elevate mood but also amplify my emotions to the extent that they can make me get in to panic.

I get to sleep easily but I find myself waking up earlier than usual.

Does Modafinil unlike benzos have a cumulative build up time to reach steady state?

Sorry my post seems to have gone too long.

What I would want to know is, did you try mixing benzos with modafinil when you were on it?
I think a combination of the mood elevating and cognitive enhancement effects of modafinil with the anxiolytic effects of a benzo like ativan would help me immensely in conjunction with my single dose Milnacipran.

 

Re: Which AD has closest effect to Modafinil's

Posted by bearfan on July 24, 2010, at 22:18:28

In reply to Which AD has closest effect to Modafinil's, posted by vic80 on July 19, 2010, at 17:20:05

I've tried a lot of things and its really an apples to oranges kind of thing. I've seen Modafinil been classified more as a 'wake promoter' than a stimulant. I've used it before and it does give me a bit of a 'lift' but its almost always used as an augment with an antidepressant rather than as an antidepressant by itself in the real world. To me, the most similar drug was dexedrine (which was marketed as a antidepressant a long time ago), but even thats not a great comparison. I've tried alot of antidepressants and since many people get different reactions (ie sleepy etc) its tough to give out a name. Modafinil is a precursor of Adrafinil so that is most drug gives you a mood lift, that woudld be the most similar.


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