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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by linkadge on May 1, 2010, at 19:46:15
http://bloodjournal.hematologylibrary.org/cgi/content/full/101/8/3212
Here we show that 3 structurally distinct SSRIsfluoxetine, paroxetine, and citalopramact directly on Burkitt lymphoma (BL) cells to trigger rapid and extensive programmed cell death. SSRIs unexpectedly stimulated calcium flux, tyrosine phosphorylation, and down-regulation of the c-myc and nm23 genes in Burkitt lymphoma cells remaining faithful to the biopsy phenotype. Resultant SSRI-induced apoptosis was preceded by caspase activation, poly(ADP-ribose) polymerase-1 (PARP-1) cleavage, DNA fragmentation, a loss of mitochondrial membrane potential, and the externalization of phosphatidylserine, and reversed by the overexpression of bcl-2.
Posted by Phillipa on May 2, 2010, at 0:19:39
In reply to This just doesn't sound good, posted by linkadge on May 1, 2010, at 19:46:15
Link the link didn't work for me? Phillipa
Posted by ed_uk2010 on May 2, 2010, at 7:08:47
In reply to This just doesn't sound good, posted by linkadge on May 1, 2010, at 19:46:15
>Here we show that 3 structurally distinct SSRIs fluoxetine, paroxetine, and citalopram act directly on Burkitt lymphoma (BL) cells to trigger rapid and extensive programmed cell death.
It seems to be saying that all three SSRIs unexpectedly killed the cancer cells.
Burkitt lymphoma is very nasty type of cancer but it is normally responsive to chemotherapy.
Posted by bleauberry on May 3, 2010, at 17:50:01
In reply to This just doesn't sound good, posted by linkadge on May 1, 2010, at 19:46:15
Yeah I agree. Doesn't sound good. If for no other reason, we don't know what the ramifications of any of that stuff are.
So SSRIs kill cancer cells? Well, I dunno about that. I've never heard of any anecdotal reports of any lymphoma or cancer patients mysteriously getting better while on their antidepressant.
This does remind me of a study I saw on Zyprexa. Wish I could find it again. It was a genetic study. In it they showed how Zyprexa turned up the volume, or turned on those that were off, on 30+ different genes. At the same time, it turned off or turned down the volume on 30+ other genes. Obviously some of the genes they turned on were the ones that turn food into fat.
But I think what it all means is this. All meds have a multitude of biological impacts at a genetic and molecular level that we don't know anything about. And that quite possibly some of those things we don't even know about are the things bringing about the healing and not the extra serotonin or whatever.
This is the end of the thread.
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